Dementia with Lewy bodies

The discovery that double-stranded RNA can efficiently silence gene expression (RNA interference, RNAi) was made by Andrew Fire and Craig Mello in 1998 in the worm C. elegans (Fire et al., 1998). It has since been hailed as one of the most important innovations in modern molecular medicine and accordingly, the pair were awarded the Nobel Prize in Medicine and Physiology in 2006. This discovery opened up a whole new field of biological research which has impacted all aspects of medicine including

A general trend in dual ACC1/ACC2 inhibition was often encountered among the 125 compounds tested: good ACC1 inhibition was linked to good ACC2 inhibition.4 The same group elaborated on this study by examining the structure–activity relationship (SAR) for the pyrazole part and the substitution at position 9 of the 1,9-diazaspiro[5.5]- undecane. In this study, additional pharmacokinetics were studied along with the IC50 values for ACC1 and ACC2, such as the lipophilic ligand efficiency (LipE)