Fibrosis

Can viruses used as vectors in the process of gene therapy be an effective treatment for Cystic Fibrosis? Firstly, Cystic Fibrosis is a genetic and recessive disease that mostly affects the lungs and pancreas. This leads to phlegm accumulation, salty sweat, male infertility, shortness of breath and increased risk of infection, which all contribute to premature death (CFF, 2017). Since it is recessive, you need two copies of the gene to manifest the disease, but 1/30 Americans have at least one copy

Cystic fibrosis is due to a mutation in the gene that encodes cystic fibrosis transmembrane conductance regulator (CFTR) protein. It effects the exocrine glands which are responsible for making mucus and sweat. It causes a thickening of the mucus in your body and increases the salt content of your sweat. These can lead to problems including problems absorbing oxygen, lung infections, inhibit digestive enzymes from reaching your small intestine, dehydration, increased heart rate, lower blood pressure

Cystic fibrosis is a autosomal recessive inherited disease that affects many organ systems. Over time the outcome for patients with the disease has improved drastically. The life expectancy for patients has increased to 37 years old, compared to 31 years old (O’ Sullivan, 2009). Researchers have reviewed the etiology, pathogenesis and clinical manifestations for cystic fibrosis. The cause of Cystic Fibrosis is mutations in a single gene on chromosome 7 that encodes for the cystic fibrosis transmembrane

reasons. An example of one of these disease is Cystic Fibrosis(CF). There is not much popularity associated with Cystic Fibrosis because there’s limited research on the topic. However, according to the Cystic Fibrosis Foundation, C.F. is a genetic disease that is essentially a severe cold that never goes away. Mucus builds up in the lungs as well as the pancreas and can impair a persons breathing capabilities (About Cystic Fibrosis 1). Cystic fibrosis is a

Running head: Cystic Fibrosis: A Defect in the CFTR Gene Cystic Fibrosis: A Defect in the CFTR Gene Alexandra L Allen Southern Union State Community College RAD212: Image Evaluation and Pathology Abstract What is Cystic Fibrosis? How does it affect people living with it? Cystic Fibrosis, also known as CF, is a life-threatening hereditary disease. It is inherited by a faulty cystic fibrosis transmembrane conductor (CFTR) gene

mutations are known to date. The greatest challenge faced when attempting to cure Cystic Fibrosis through gene therapy is the use of a vector that will successfully transport the correct CFTR gene to restore lung functionalty. Across the sources the debate of viral vectors against non-viral vectors is dominant as viral vectors are show to have a

Introduction Cystic fibrosis Cystic fibrosis (CF) is a lethal autosomal recessive disorder with a clinical incidence of 1 in every 3500 newborns1. Currently, over 4000 Canadians have CF, with 60% being adults2. In the past, CF was considered a fatal disease with a life expectancy of less than two years, however, advances in enzymatic and antibiotic therapy have greatly improved the life expectancy of patients afflicted with CF3. Currently, the median age of Canadian CF patients is 50 years2. CF

Cystic Fibrosis Cystic fibrosis is the most common lethal inherited disease, affecting about 30,000 patients worldwide. In the past decade, strides in patient management and the development of new pharmacological agents, coupled with scientific and technological advances, have increased the mean life expectancy of CF patients to approximately 30 years of age (approximately 50% of CF patients live to the age of 30). As early as 30 years ago, the median survival age was 8 years. Chronic

The following are a few common myths and truths about Cystic Fibrosis: Cystic Fibrosis is contagious. False, CF is not contagious. It is a disease that is genetically inherited by the child from his or her parents who either have the gene or are carriers of the gene. The gene that codes for Cystic Fibrosis has been found. True, the gene that produces the cystic fibrosis transmembrane conductance regulator protein, CFTR, is known. A defect in this protein interferes

Cystic fibrosis is a genetic disease that affects the respiratory system, digestive/endocrine, and reproductive system. A defective gene produces an abnormally thick mucus in the trachea and causes a blockage in the trachea, damages lung, and resulting in failure of the respiratory system. The mucus also interferes with the pancreas, which it prevents the secretion of digestive enzymes that help dissolve food, causing difficulty in absorbing nutrients. CF causes infertility, particularly in men.