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5 ASA Synthesis

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It is important to remember that 5 ASA compounds even if generally tolerable, are associated with diarrhea in some patients and some clinicians thus prefer not to use them in patients with severe acute ulcerative colitis.[27] Many reports cite impaired renal function from prolonged 5 ASA use and therefore renal function must be monitored in patients receiving long term therapy. Other side effects of 5 ASA agents include dizziness, fever, headache, abdominal pain, nausea and rash. Due to a hypersensitivity to 5 ASA, a small percentage of patients may experience worsening diarrhea and abdominal pain. However, in general 5 ASA agents are considered safe and effective for induction and maintenance of remission in mild to moderate

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