2. It is also given in treating pain associated with the fibromyalgia, injury of the spinal cord, post herpetic neuralgia. And sometimes in the lower back pain. 3. It also helps in the treatment of the stress disorder related to post trauma and also in the cases of the obsessive and compulsive disorder. 4. In cases of the partial seizures with or without the secondary generations drug can be used as an adjuvant therapy. CONTRAINDICATIONS:- Given below are the contraindications of pregabalin:- 1. Patients who have the galactose intolerance should avoid the drug. 2. Drug should be avoided during the lactation period. 3. Hypersensitivity towards the pregabalin and its analogous. 4. Who have glucose-galactose malabsorption are resisted to take …show more content…
Propoxyphene and pregabalin, if given concomitantly then the side effects of pregabalin gets worsen. AMITRIPTYLINE:- INTRODUCTION:- Amitriptyline is the drug that belongs to the tricyclic antidepressants classification. It is the drug which is mainly used for the depression and anxiety. But the drug has shown the benefits in relieving the pain. The drug mainly relieves the pain by the rebalance of the chemicals in the central nervous system which control the nociceptive receptors that induces the pain and also the chemicals that helps in inducing the sleep. Elavil is the name of the drug in the market . PHARMACOKINETICS:- Amitriptyline is the drug which is chemically lipophilic in nature and its solubility in water at the temperature of 24 degree Celsius is about 9.71mg/L . The drug goes under first pass metabolism and fastly absorbed from gastrointestinal tract. It is metabolized by the enzymes CYP3A4, CYP2C19 and CYP2D6 in the liver and gets converted to nortriptyline . The plasma protein binding percentage of the drug in the body is about 96% . Sulfonates or glucuronide conjugates or in free form they are eliminated in the urine . Some of it is excreted in the form of feces. …show more content…
In nocturnal enuresis. 4. In urinary incontinence, amitriptyline is being accepted for the treatment. 5. Somewhere in insomnia and attention deficit/hyperactive disorder amitriptyline is used . 6. Also in the biliary dyskinesia treatment drug is indicated. 7. In the phobic/obsessional states. 8. In the cases of bedwetting. CONTRAINDICATIONS:- The drug is contraindicated in the following cases:- 1. Any recent or past history of myocardial infarction. 2. Any related history of porphyria in the family. 3. In children below 6years for treating bedwetting and in children below the age of 16 years for depression. 4. People suffering from arrhythmia 5. In cases of some types of depression like manic depression. 6. Patients on MAOI should avoid taking amitriptyline, and if they are needing amitriptyline the MAOI should be stopped 2 weeks prior. ADVERSE EFFECTS:- The side effects of amitriptyline are:- 1. Impotency 2. Libido loss 3. Confusion 4. Delirium 5. Anxiety 6. Agitation 7. Insomnia 8. Drowsiness 9. Nightmares 10. Cardiovascular effects includes the elongation of the Q-T interval, sinus tachycardia and orthostatic hypotension . INTERACTIONS:- Amitriptyline has following interactions with some common drugs. These
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The pain spoke meanwhile sadness pierced through skins, however, the drugs was able to silence the beast within. Antidepressant the legal drug of choice is prescribed by doctors to treat a variety of medical conditions. These drugs are often prescribed by themselves or sometimes with others with the intent of having a greater effect on the beast within. Antidepressants come in several classes with each being stronger than the one before. Although antidepressants are often prescribed to treat depression in recent times the distribution of these drugs across the medical field have widened. Since the 1950s, medical personnels have moved from having two antidepressants: iproniazid and monoamine-oxidase inhibitor used to treat tuberculosis to now
Results obtained in the recent years give some hope that ketamine which is a global NMDAR antagonist could be the fast and long- acting novel antidepressant. Antidepressant–like activity of ketamine was shown in many preclinical studies (1–7). The single non-anesthetic dose of ketamine reversed symptoms of major depression (MDD) in clinical conditions (8). These antidepressant effects of ketamine also occurred in patients who suffered from resistant depression or suicidal ideations (9–12). Despite a successful
I was so interested in reading your post because I wanted to know the other ways to manage Amitriptyline overdose since you've mentioned that there is no antidote for it. You were right when you said that cardiac condition and airway clearance must be carefully monitored to avoid complications or worst, death. It is important also for the nurse and/or the patient who is taking this drug to know the anticholinergic effects, such as dry mouth, photophobia, hallucinations, blurred vision, and tachycardia, so that proper interventions and management can be done. Because there is a high risk for suicide when this drug is taken, psychotherapy can be provided to the patients so that they can express their feelings and thoughts, hence, help decreases
When these chemicals are released from nerve cells they act to lighten mood. When they are reabsorbed into the nerve cells, they no longer have an effect on mood. Nortriptyline works by preventing this re-absorption of noradrenaline and serotonin back into the nerve cells. Therefore, it helps prolong the mood-lightening effect of any released noradrenaline and serotonin”.
These are used for the relief of common aches and pains such as headache, toothache, period pains, fever and symptoms associated with cold and influenza, muscular and joint pains. These medicines are considered over-the-counter medicines and available without the need for
At the moment, it can be used to shrink tumors in the brain, spine, and esophagus. If these specific tumors were left untreated a human would experience trouble eating and drinking, pain on where the tumor is located, strong headaches, and even
She explains that because the pain is in the brain, the better that the brain works, the more that it will be able to control the pain. Medications such as Deprenyl boost the ability of the brain to counterattack the pain. There are also condition-specific medication the Dharma speaks of. These medications are to treat the root causes of the specific conditions. So, like Tylenol is to reduce a fever or headache, Lyrica is to treat Fibromyalgia or chronic pain. Dharma explains, though these are to help relive the patient from the pain, this may not always be the outcome and may just relieve the underlying conditions causing the
Used to treat heartburn, upset or sour stomach, peptic ulcer and related pain, gastro esophageal reflux disease (GERD). It is also used kidney problems to reduce phosphate levels.
One must intake, this medicine only after consulting with the doctor. Since, by consuming this medicine for long duration or in inadequate quantity, may cause serious for instance liver problems, nausea, constipation, dizziness, drowsiness, etc. To prevent the side effects one must avoid intake of alcohol consumption and must take a healthy diet. Moreover, one must only intake the dosage amount as suggested by the doctor. Since, the dosage of the medicine depends on several factors like, age, medical condition, weight, etc. so one must intake the right amount of
The patient does have a history of migraine headaches. She was started on nortriptyline by an ear, nose, and throat specialist years ago. She is been on it at least two plus years. She is wondering whether this is something she really needs to stay on or not. She very infrequently now will have a migraine.
Although Dextroamphetamine is the only FDA approved medication treatment of ADHD in children under 6 years of age, inefficient evidence of safety and efficacy in this age group resulted in the AAP NOT recommending its use in this population.
Pain is a prevalent symptom among patients in general and in cancer patients. The treatment and control of pain have been through the years one of the most significant concerns of health workers and a constant inspiration for the scientific community in the search for the ideal drug to treat pain with the least possible amount of adverse reactions.
This drug is used as an antidepressant. Anxiety, dizziness, blurred vision, dry mouth, diarrhea, and weight gain or loss are common effects of the medications and with aging. But serious effects such as fever; seizures, tremors, chest pain, hepatic necrosis, renal failure, abnormal bleeding, and infection should be cautioned. The dosage of this medication should not be prescribed more than 40 mg daily. Monitoring for mental changes when taking this medication is needed. It should be cautioned to watch for a change in behavior from depression into a mental illness. If this occurs medical attention is needed. Nurses should also assess elderly patients taking diuretics for signs of suggesting syndrome of inappropriate secretion of antidiuretic