Advantages And Disadvantages Of Amitriptyline

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2. It is also given in treating pain associated with the fibromyalgia, injury of the spinal cord, post herpetic neuralgia. And sometimes in the lower back pain. 3. It also helps in the treatment of the stress disorder related to post trauma and also in the cases of the obsessive and compulsive disorder. 4. In cases of the partial seizures with or without the secondary generations drug can be used as an adjuvant therapy. CONTRAINDICATIONS:- Given below are the contraindications of pregabalin:- 1. Patients who have the galactose intolerance should avoid the drug. 2. Drug should be avoided during the lactation period. 3. Hypersensitivity towards the pregabalin and its analogous. 4. Who have glucose-galactose malabsorption are resisted to take…show more content…
Propoxyphene and pregabalin, if given concomitantly then the side effects of pregabalin gets worsen. AMITRIPTYLINE:- INTRODUCTION:- Amitriptyline is the drug that belongs to the tricyclic antidepressants classification. It is the drug which is mainly used for the depression and anxiety. But the drug has shown the benefits in relieving the pain. The drug mainly relieves the pain by the rebalance of the chemicals in the central nervous system which control the nociceptive receptors that induces the pain and also the chemicals that helps in inducing the sleep. Elavil is the name of the drug in the market [19]. PHARMACOKINETICS:- Amitriptyline is the drug which is chemically lipophilic in nature and its solubility in water at the temperature of 24 degree Celsius is about 9.71mg/L [20]. The drug goes under first pass metabolism and fastly absorbed from gastrointestinal tract. It is metabolized by the enzymes CYP3A4, CYP2C19 and CYP2D6 in the liver and gets converted to nortriptyline [21]. The plasma protein binding percentage of the drug in the body is about 96% [22]. Sulfonates or glucuronide conjugates or in free form they are eliminated in the urine [23]. Some of it is excreted in the form of feces.…show more content…
In nocturnal enuresis. 4. In urinary incontinence, amitriptyline is being accepted for the treatment. 5. Somewhere in insomnia and attention deficit/hyperactive disorder amitriptyline is used [24]. 6. Also in the biliary dyskinesia treatment drug is indicated. 7. In the phobic/obsessional states. 8. In the cases of bedwetting. CONTRAINDICATIONS:- The drug is contraindicated in the following cases:- 1. Any recent or past history of myocardial infarction. 2. Any related history of porphyria in the family. 3. In children below 6years for treating bedwetting and in children below the age of 16 years for depression. 4. People suffering from arrhythmia 5. In cases of some types of depression like manic depression. 6. Patients on MAOI should avoid taking amitriptyline, and if they are needing amitriptyline the MAOI should be stopped 2 weeks prior. ADVERSE EFFECTS:- The side effects of amitriptyline are:- 1. Impotency 2. Libido loss 3. Confusion 4. Delirium 5. Anxiety 6. Agitation 7. Insomnia 8. Drowsiness 9. Nightmares 10. Cardiovascular effects includes the elongation of the Q-T interval, sinus tachycardia and orthostatic hypotension [25]. INTERACTIONS:- Amitriptyline has following interactions with some common drugs. These

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