(A) SIGNIFICANCE: Despite the advances in our understanding of aging [1,2,3,4], the physiological and molecular correlates of aging-dependent alterations in specific neurons that underlie learning and memory storage are poorly understood. Such information is essential to delineate molecular underpinnings of aging-related changes to develop novel strategies for therapeutic intervention of the aging-associated specific deficits in learning and memory storage. Our proposed studies are highly significant to the studies on human aging and cognition in three major ways. (1) This proposal is highly relevant to human learning because of the focus on mechanisms of aging dependent changes in learning using a simple, but well characterized neural circuitry - the gill withdrawal reflex (GWR) of Aplysia. It is important to recognize that many concepts that are central to our overall understanding of learning and memory were established using Aplysia. For instance, the role of the cAMP signaling system, or branch-specific storage of memories discovered in Aplysia has also been shown to be important in Drosophila and the mouse [5]. Therefore, it is expected that contributions of the proposed studies on aging will be conserved in mammals. (2) Because of two main reasons studying aging using defined synapses is critical for identifying specific cellular and molecular mechanisms of aging associated memory decline. First, studies using populations of neurons will dilute the specific changes
Once you reach a certain point in your life how do you just forgot? Is there a certain point in your life where your memory is affected? The common question going around is does your memory decline with age. One reason this is important because it will affect all of us. We will all get old and this can greatly affect our health. The research can show how our older age will affect our memory.
The research aims at determining the affect of dementia on the lives of individuals and how it impacts on their social interactions. The research will also identify the ways in which aging individuals can refrain themselves from falling prey to this disease. It will highlight some important information for caregivers who will better understand this disease and will know how to deal with people who have this disease. As we all
The elderly population is growing rapidly and now makes up greater than thirteen percent of the United States population. (APA, 1994). With such a record growth, there are different aspects to aging that are still being analyzed. Many may think of reaching late life as a rite of passage, but many face this time with a different view. Through the movie "UP', we are granted an opportunity into view the struggles of an elderly widowed man by the name of Mr. Fredrickson and the challenges in which he faces in his later life. The movie, takes one on a journey through his sorrows and his triumphs until he realizes what the true meaning of happiness is.
There are people who think that older adults are not capable of learning new information because of the number of neurons in their brain decline as they age. In the PBS video “Stealing Time”, the old cage potato rats were given a change of scene with an enriched environment and the results were that their dendrites grew and made new synaptic connections where there were none before. These rats were better on future tasks than the old rats that were not given a change of scene. When older adults are doing a task in a laboratory setting they are less efficient at processing the information presented to them and their reaction time is slower. “Older adults show more brain activity between the prefrontal cortex and the medial temporal lobe than
Cognitive aging is the term to describe changes in cognition with age. While Salthouse (2004) found that with cognitive aging comes cognitive decline regardless of the individual, Hayden and partners (2011) found that most (65%) elderly persons showed slow decline that does not substantially affect abilities, 27% experienced moderate decline, and only 8% showed substantial cognitive decline. These new findings show that in fact there may be individual variability when it comes to cognitive aging. One factor shown to affect cognitive aging is race (Glymour and Manly, 2008). Thus, in this paper we will review and analyze findings pertaining to cognitive aging as related by race to better understand this relationship and will also discuss suggestions for future research.
Whether aging impair learning related long-term plasticity at LESN-L7MN synapses? (Aim 1). Though several studies have brought insights into the aging associated behavioral, cellular and electrophysiological changes, none of these studies have examined learning related long-term synaptic plasticity at LE SN-L7MN synapses connections of GWR during aging. First, using the semi-intact preparation [6,34], we will measure basal electrophysiological
When taking care of an elderly parent, it’s natural to observe their behaviors. In most cases, caretakers are looking for early signs of any of the myriad conditions that afflict seniors, like Alzheimer's. However, it’s important to understand the difference between a memory lapse and Alzheimer's, especially if the senior is living in one of Richmond VA retirement communities. At a retirement community, Alzheimer's residents would receive different treatment plans.
Cognitive function depends on proper wiring and functional connections within neuronal circuits. Despite advances in understanding human aging and aging-associated cognitive decline, molecular and cellular mechanisms underlying aging associated impairments in learning and memory are still poorly understood. In particular, very little is known about whether physiological and molecular changes in identified neurons that are important for learning lead to aging associated decline in long-term memory storage. We approach this problem by delineating the aging associated changes in two well characterized neurons, presynaptic LE sensory neurons (LESNs) and postsynaptic L7 motor neuron (L7MN) of Aplysia whose normal functioning is critical for the learning of gill withdrawal reflex (GWR). Along with us, others have used Aplysia as a model to understand aging associated changes in neuronal physiology, response to neurotransmitters, gene expression and behavioral learning. In a study that examined electrophysiological and gene expression changes in identified neuron R15 of Aplysia, we recently described specific changes in burst firing and action potentials, expression of several genes in R15 during aging and specific changes in the expression of key regulators of transcription and translation in four identified neurons (L7, L11, R2, R15) of Aplysia. The long-term goal of this project is to identify synaptic
What are scientists using to diagnose Alzheimer 's Disease and other memory disorders early and why should they do so when there is still no cure for it?more
Cognitive aging is commonly labeled strictly as memory and only found in “some people”. However, this is not true. The knowledge of cognitive aging has grown immensely, but there is still much to be learned. The surface has only been scratched with many more questions to be answered. Cognitive aging is worthy of study and effects everyone, but there is also much more is still to be learned.
Alzheimer's is a progressive, degenerative and fatal disease in which cell to cell connections in the brain are lost. It is the most common type of dementia, and its also most common in patients that are 65 or older. Alois Alzheimer was the founder of this disease. Up until the 1960’s it was known as senile dementia, and It was also considered a normal part of aging. In the early 1970’s, scientists began to go more in depth with their research. Any type of dementia is characterized by the loss of neurons and synapses in certain subcortical regions of the brain. Soon, the hippocampus, temporal lobe, and parietal lobe start to degenerate, as well as parts of the frontal cortex and cingulate gyrus.
Why does the human brain age? Brain aging is a part of human life and a big part of society as the awareness for brain aging increases. Over time memory tends to become less efficient as we age and the neurons in the brain decreases (Bendheim, P.E. (2009). By 2050 in the US, 20 percent of the population will be 65 years or older. And as the elderly population increases, so will the incidence of age-related neurological disorders (Perlmutter, David. (2004). Therefor it is important to understand the aging brain, and how to keep the brain functioning as one ages.
Cognitive function depends on proper wiring and functional connections within neuronal circuits. Despite advances in understanding human aging and aging-associated cognitive decline, molecular and cellular mechanisms underlying aging associated impairments in learning and memory are still poorly understood. In particular, very little is known about whether physiological and molecular changes in identified neurons that are important for learning lead to aging associated decline in long-term memory storage. We approach this problem by delineating the aging associated changes in two well characterized neurons, presynaptic LE sensory neurons (LESNs) and postsynaptic L7 motor neuron (L7MN) of Aplysia whose normal functioning is critical for the learning of gill withdrawal reflex (GWR). Along with us, others have used Aplysia as a model to understand aging associated changes in neuronal physiology, response to neurotransmitters, gene expression and behavioral learning. In a study that examined electrophysiological and gene expression changes in identified neuron R15 of Aplysia, we recently described specific changes in burst firing and action potentials, expression of several genes in R15 during aging and specific changes in the expression of key regulators of transcription and translation in four identified neurons (L7, L11, R2, R15) of Aplysia. The long-term goal of this project is to identify synaptic and molecular mechanisms contributing to aging associated decline in
To understand the cognitive changes, they further used contextual fear conditioning and radial arm water maze paradigms (RAWM) to study aging effect to hippocampus related learning and memory. Mice injected with young plasma had increased freezing response in contextual, but not cued, learning and showed significant improvement on fear memory. They also exhibited enhancement in learning and memory in finding hidden platform location. On the other hand, no change was observed for aged mice and aged mice injected with aged plasma. Interestingly, these effects were reduced by heat denaturation. Thus, the heat-labile factors from young blood may rejuvenate cognitive ability for the aged mice.
It is clear to neurobiologists that aging results in a decrease in brain size as well as a decrease in the efficiency of brain functions. It has been a widely held belief that aging causes neurons to die and for the overall number of neurons to decrease as one reaches old age. Studies