Alopecia areata (AA) is an autoimmune disease that causes temporary or permanent hair loss. The body attacks its own hair follicles, which ultimately causes them to stop growing. Typically, it is found in small patches on the scalp but it can be diagnosed anywhere on the body. According to Petukhova et al. (2011) this disease physically impacts 5.3 billion people just in the United States, affecting about 1-2% of the population. There is no known cure of AA and there is little evidence suggesting it is stress related. Geneticists have been able to use genome wide association studies (GWAS) to recognize genes that have affiliation with the onset of alopecia areata. Alkhalifah et al. (2010) observed monozygotic twins because they are likely to have similar criterions and patterns of hair follicle deterioration. They also observed that AA might be inherited due to patients having a family history of this autoimmune disease. Human leukocyte antigens genes (HLA) are affiliated in alopecia areata along with several HLA class I and II alleles (Alkhalifah et al. 2010). The HLA class II antigen is a main contributor to the development of AA. This gene is a big expresser on the hair follicles and it is expressed on immune cells, giving antigen peptides to a specific T cell, CD4+. These findings suggest that CD4+ cells do indeed …show more content…
According to Alkhalifah et al. (2010), due to genomic wide association screening there has
This is not known for sure if this is what alopecia areata is. It is a hypothesis, it’s based on certain antigens in the hair follicle. Many reports and printouts I came across kept saying, “the etiology of alopecia areata is entirely unknown"(e.g. Price 1991, Parret 1984, Paus 1993). According to (editorial 1984) evidence hair loss is a result of immune system activity. Which is then classified as an autoimmunity. This evidence is based on observations of an immune cell in and around the hair follicles (Parret 1984) and the knowledge that some
The challenges of elementary, middle, and high school accumulate and progress through the years. One of them being social status and appearance. I for one, had fallen to the bottom of the totem pole. I was considered a bulls-eye, targeted by those that wished to shower me with arrows in the form of harsh words and taunts. I was an outcast, rejected from the norm. Although laborious, I climbed up the totem thanks to achieve strength and confidence.
AAT deficiency is caused by a genetic defect (gene mutation). The gene mutation is passed from parent to child (inherited). The disease typically develops only if a person inherits the defective gene from each parent.
Alopecia Areata is a common autoimmune skin disease that attacks the hair follicles and causes hair loss in places like the scalp, face, and sometimes other places on the body. Alopecia is very common because it affects about 6.8 million people in the United States alone and can affect people of all ages, genders, and ethnic groups.
As a senior in highschool, one of my future goals is to become either a doctor or an administrator in health sciences. As long as I can remember, I had a fascination with animal documentaries when Animal Planet was very popular. However, then in high school, I was introduced to the Human Body, and it fascinated more than ever. I want to become a doctor because I have the drive to save other people’s lives.
When your child is diagnosed with alopecia, you probably have scoured the web for relevant information about the disease. Even if you know everything you know about hair loss, nerve-wracking to meet this guy has such a serious topic. The first step is to have a chat child will learn how to think through. How old is your child? O when that day will be the most open to talk to? Style of speaking for him or her what to rage around? Which ones to help him or her to stay calm and collected?
After many years of progress, the popular culture has begun to appreciate Black people as much as Black people love themselves. The western world is beginning to recover from many years of racial discrimination. Fashion trends usually associated with minority groups have gone from being shunned in popular culture to embraced. Previously, minorities would be forced to conform their image to look more standard, and within recent times, the standard has changed to encompass more people. A prime example of this is the acceptance of natural hair.
Although folliculin function is speculative, its highly conserved. FLCN gene contains 14 exons and exon 11 is constituted as a mutational hotspot due to the majority BHD patient population contain mutations in this exon. As many as 84 variants in the folliculin gene are reported to cause BHD by which majority of the mutations cause FLCN truncation deletion (Hasumi et al., 2008). FLCN protein structure and
What is Alopecia Areata and can I get it? Alopecia Areata, by definition, is a sudden loss of hair that generally begins with one or more circular bald spots that can potentially overlap. Alopecia Areata is very common; it affects 4.6 million people in the United States (Mackay-Wiggan 31). It is one of the most common autoimmune diseases in the world, making it more common than diabetes! Everyone and anyone can be affected by Alopecia: men, women, and all races. There is no known information on how frequently Alopecia Areata essentially appears. From my experience of seeing my brother deal with Alopecia Areata, I’ve learned to be proud of who I am and most importantly, be confident about myself and while others may not experience the
My daughter was a year and a half when she was diagnosed with Alopecia areata. “Alopecia areata is considered an autoimmune disease, in which the immune system, which is designed to protect the body from foreign invaders such as viruses and bacteria, mistakenly attacks the hair follicles, the structures from which hairs grow. This can lead to hair loss on the scalp and elsewhere” (https://www.niams.nih.gov/Health_Info/Alopecia_Areata/default.asp). Alopecia areata is not a life threatening disease but it is a traumatic disease.
Alopecia Areata: A disease which causes the body to form antibodies against hair follicles. It can result from such factors as stress, genetics and the immune system. Alopecia Areata causes sudden, smooth, circular patches of hair loss.
Asthma and Allergy are accepted conditions that involve both genetics and environmental bothers (contributions). Also, this type of condition is a disease striking the cells of the human body’s immune system; however, it is inflammatory response to a normally
treatments to treat hair thinning and male or female pattern baldness. Ranging from PRP, mesotherapy to FUE, FUT
While most detrimental genes would be eradicated through evolution, the genes for autoimmune disorders seem to be increasingly rife in humans. We will first address the persistence of these genes in the context of ancient vs. modern environments and lifestyles. By comparing the frequency of autoimmune-related SNPs between ancient humans and modern humans, we will be able to better understand the rise in autoimmune disease prevalence. If the frequency of autoimmune-related genes has remained fairly constant or increased over thousands of years, it can be inferred that autoimmune diseases were not large contributors to the detriment of human health and were therefore not selected against. Thus, the sudden increase in autoimmune disease prevalence must be related to interactions between these genes and the environment. If this is true, these autoimmune genes would only recently have become candidates to be selected
Hair loss is a condition affecting both men and women. There are several causes of hair loss. In men, hereditary factors play an important role in hair loss. Such a condition is termed as male pattern baldness or androgenetic alopecia. This is linked to elevated levels of DHT in the scalp. This is characterized by hair loss in the temples and top regions of head and presence of thinning hairs elsewhere.