Analysis Of Charcot-Marie-Tooth

MCA: hemiparesis or hemiplegia of lower half of the contralateral face, Hemiparesis/hemiplegia of the contralateral upper and lower extremities, sensory loss of contralateral face arm and leg, ataxia and contralateral extremities, speech impairments or aphasia usually from a left brain lesion; perceptual deficits, visual disorders

Charcot-Marie Tooth Disease is a chromosomal disease that affects the body's peripheral nervous system. This chromosomal disease gives rise to weakness throughout the body and a loss of feeling in the limbs (Obesity, Fitness & Wellness). There are two different forms of Charcot-Marie Tooth Disease: CMT1 and CMT2. Nerve conduction testing (NCV) is implemented to detect which form a patient has. NCV is used to ascertain the speed in which the messages travel through the nerves. If the message speed is slow, the patient has CMT1, and if the speed is normal, the patient has CMT2 (Krajewski

The patient is an 80-year-old right-handed white female, who presents with her male partner for evaluation of left lower extremity symptoms. She did present for an EMG nerve conduction study in May. At that time, she gave a history of intermittent numbness into the anterior lateral thigh. The numbness rarely extended below the knee at that time, and it rarely occurred on the right. There was no clear radicular component. Her exam was normal. Her EMG of the left lower extremity was limited because she is on Pradaxa, but it was normal and CBs were consistent with a mild motor neuropathy. The diagnosis was possible meralgia paresthetica. The patient now states that the numbness is intermittent. It is on the anterior thigh, but now it goes down into the calf anteriorly and

Orphan diseases are rare diseases that affect less than 200,00 people nationwide. Due to the fact that they are not commonly found, they are are often overshadowed by more prevalent diseases, such as malaria or hepatitis. Therefore, this is often not enough government funding needed to research these diseases. Charcot Marie Tooth Disease (CMT) is one of the most common, yet unknown, rare neurological disorders. This disease mainly affects the nervous systems, often impairing motor skills and causing the decaying of muscles in the arms and legs. Charcot Marie Tooth Disease was first discovered in the early 1900s by Professor Jean Martin Charcot and Pierre Marie of France, and Henry Howard Tooth of England (Muscular Dystrophy Association). There

Myelopathy Gait Chronic spinal cord compression causes myelopathy. Myelopathy is when a person losses their equilibrium with pitiable synchronization, diminished dexterity of the hands, turgid limitation and detachment in a non-dermatomal configuration. The person will also annotation that they are maladroit and will often decline things. Some noticeable things would include the script has changed, how they button buttons, zip zippers ect.

When the nerves of the body become damaged and no longer has the myelin sheath to protect them, then the damage causes the brain to fail to correctly transmit signals throughout the body. This causes the nerves to function irregularly which leads to problems with vision, balance, muscle control, and other basic body functions. Furthermore these problems can cause paralysis, fatigue, muscle weakness or muscle spasms, blurred vision or double vision, numbness and tingling, sexual problems, poor bladder or bowel control, pain,depression, problems focusing or remembering, and tremors.

The EMG of the lower extremities was normal. The MCV revealed mainly decreased amplitudes of the sensorimotor nerves, but with decreased tibial velocities bilaterally.

Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States.

What is happening to me? In my 20 years of life I’ve never experienced anything like this. For the past few days I’ve noticed that I can’t move my right foot or ankle upward. To walk, I’m forced to bend my knees more than usual to prevent my feet from dragging along the ground. If I don’t, it’s painful. Today I went to the grocery store to pick up some supplies to make apple pie and I noticed everyone’s eyes on me. I could hear them wondering why I walked with such a weird gate. I was hoping it would go away and that I simply hurt my ankles from running too much but it’s been a whole week and it seems to be getting worse; not better. It’s so frustrating since all my life, for as long as I can remember, I’ve been a runner.

Neurologic—decreased vibratory sensation in the lower legs; bilaterally decreased knee reflexes; no asterixis; decreased vibratory sensation in the lower legs; bilaterally decreased knee reflexes; no asterixis; normal sensation and position sense in upper and lower extremities; cranial nerves II

In the current study the most frequent FFB was the fourth IM bursa (IM4/5) (20.1%) while the most frequent SM bursa was the first (16.1%) with the least frequent one of all being the third SM bursa. The same finding was reported by Bowen CJ et al (18) and Hooper L et al (24). The SM bursae are considered mostly pathological or symptomatic so their hypertrophy might cause pain or cause activity limitation. (18) Ultrasound detectable synovial hypertrophy of the MTP joints was present in 60% of the studied patients. Similar results were detected by Bowen CJ where the US detectable MTP synovial changes were present in 67.5 % of his patients. (25)There was no statistically significant correlation between the total number of FFB and CDAI.

Both natural teeth and teeth with restorations survive best in an oral environment that is clean and where the intake of harmful foods is controlled. Our program is designed to help prevent new cavities, preserve teeth that have been restored and manage periodontal disease. At the initial visit oral hygiene instructions are reviewed and are reinforced at subsequent recall visits. The following are helpful recommendations:

Most parents know how important it is for their children to be seen regularly by a pediatrician but many don’t know that regular checkups by a pediatric dentist are just as vital to their children’s overall health. According to a report by the American Academy of Pediatric Dentistry, by the age of 3, 5-10 % of U.S. children have oral health issues and by the age of 5, 60% will have had dental caries (decay) at some point in their lives. These statistics mean that most U.S. children will likely suffer from a variety of residual problems caused by early tooth decay.

However, the hypothesis that rickets can present as CML, thus CML is not specific for child abuse was was seriously challenged.

It is caused by an inherited genetic abnormality; the lack of an essential enzyme causes deterioration of the white matter in brain thereby preventing the proper transmission of nerve signals.