Molecular Mechanisms implicated in Bipolar Disorder: A concise Review Neurobiology of Bipolar Disorder: A concise Review Mutahar Andrabia, Muatar Maknoon Andrabi, Remesh Kunjunnia, Sandeep Sathianathana, Mukesh Kumar Sriwastvaa, Rajesh Sagarb, Rashmi Mathurc, Vivekanandhan Subbiaha* a Deptt. Of Neurobiochemistry, All India Institute of Medical Sciences, India, New Delhi-29 b Deptt. Of Psychiatry, All India Institute of Medical Sciences, India, New Delhi-29 c Deptt. Of Physiology, All India Institute of Medical Sciences, India, New Delhi-29 • Mutahar Andrabi (PhD student, Neuro Biochemistry) Email: mutahar.andrabi@gmail.com • Remesh Kunjunni (PhD student, Neuro Biochemistry) Email: remeshmarangad@gmail.com • Sandeep Sathianathan (PhD student, Neuro Biochemistry) Email: mailstosandeep@gmail.com • Mukesh Kumar Sriwastva (PhD student, Neuro Biochemistry) Email: sriwastva.mukesh6@gmail.com • Rajesh Sagar (MD) Email: rsagar29@gmail.com • Rashmi Mathur Email: mathurashmi@yahoo.co.in • Corresponding Author* Vivekanandhan Subbiah, PhD Email: svivek_aiims@yahoo.com (Corresponding Author) Key words: Bipolar Disorder, epinephrine, serotonin, dopamine, circadian system, BDNF. Bipolar disorder is a serious and devastating mental disorder. Suicidal ideation and comorbid conditions further worsen the outcome and prognosis. Abnormalities in monoaminergic pathways and signaling networks have been shown to be involved in the pathogenesis of disorder. Circadian system has
Mental illness has plagued human kind for as long as we have been on this earth. The science of psychology has made great strides in past century. The stigma of being mentally ill has begun to fall away and people are finally starting to get the help that they need to recover. Bipolar disorder is one illness that we have come to more fully understand. Through assistance from a psychiatrist, family and medication a patient with bipolar disorder can enter remission and live a normal life.
This source gives the readers an in-depth overview of Bipolar Disorder and the causes of having the mental health issue. There’s a great distinction between the ups and downs people experience and bipolar disorder. Due to the ups and downs teens and children experience, bipolar disorder is hard to diagnose during those early years. The National Center of Biotechnology Information’s research program is run by Senior Investigators, Tenure Track Investigators, Staff Scientists, and Postdoctoral Fellows which makes the source credible. The source contained
AXIS I: The most probable diagnosis from Axis I would be Bipolar I disorder, single manic episode, with mood congruent psychotic features. The client also presents some symptoms of delusional disorder and schizoaffective disorder, put the presence or absence of certain features rule these diagnoses out.
The DSM-5(2013) section on Bipolar and related disorders includes diagnoses for Bipolar I disorder, Bipolar II disorder, cyclothymic disorder, substance/medication induced bipolar and related disorder, bipolar and related disorder due to another medical condition, other specified bipolar and related disorder and unspecified bipolar and related disorder there is no classification for pediatric or early onset bipolar disorder. Though there is the following statement “the recognition that many individuals, particularly children and, to a lesser extent, adolescents, experience bipolar-like phenomenon that do not meet the criteria for bipolar I, bipolar II, or cyclothymic disorder is reflected in the availability of the other specified bipolar and related category. Indeed, specific criteria for a disorder involving short-duration hypomania are provided in Section III in the hope of encouraging further study of this disorder.” (American Psychiatric Association, 2013) . For DSM-5(2013) diagnosis purposes pediatric bipolar disorder would seem to fall under 296.89 Other Specified Bipolar and Related Disorders presentation 3 which is Hypomanic episode without prior major depressive episode. This presentation describes clients who have had one or more manic episodes but has not met the full criteria for a major depressive or manic episode. Fristad & MacPherson (2014) discuss that Bipolar disorder once was thought to be a disorder of adulthood but recently research has suggested
“According to the National Institute of Mental Health (NIMH), 2.6 percent of Americans age eighteen or older (5.7 million Americans) have [this] disorder” (Atkins, 2007, p. 4). This statistic of course does not include children or teens, or the millions of other individuals suffering from it but not knowing it has a name. What disorder might this be? It is called bipolar disorder, also known as manic-depressive disorder, and many people to this day still confuse it with “normal” feelings people go through in life. In this report I will be discussing what bipolar disorder is and its
Roughly thirty percent of Americans will experience some sort of mental disorder in their lifetime, such as bipolar disorder; a very complex disorder that is difficult to diagnose. The illness can affect anyone: Infants, adolescents and teenagers, adults, and the elderly. Seeking treatment is uncommon, being as people ignore the symptoms.
“Up to one-third of the 3.4 million children and adolescents with depression in the United States may actually be experiencing the early onset of bipolar disorder.”, according to the American Academy of Child and Adolescent Psychiatry. The battle with bipolar disorder has a severe impact on the life of adolescents resulting in the need for medication. Medication is needed for adolescents with bipolar disorder due to the fact is has negative impact on social life, academics, and on physical health.Bipolar disorder is classified as a mood disorder in which people experience series of “manic highs” and “depressed low”.
Bipolar disorder is a mental health diagnosis when a person can experience extremely different moods. It also can affect the brain during the progression of the illness. A person with this diagnosis usually experiences mood changes of extremely high moods/ manic or extremely low moods which look like depression. There are two different types of Bipolar disorders. The first is Bipolar I which is when a person’s mood can go to severe mania or severe depression. The second type is Bipolar II which is when a person never reaches the severe mania stage they will stop at the hypomania stage. After reading the required text and watching the required videos both mania and depression look completely different. When a person is experiencing a manic episode, it may look like racing thoughts, poor impulse control, and risky behaviors. While the opposite mood is depression and it may look like no energy, unable to get out of the bed and poor ADL’s. Both diagnoses require a medication regime as well as other treatment options. As I reflect on the materials regarding the disorder, I began to think about my experience with working with people with the disorder, what new things I learned and what I will change in the future when working with people who have been diagnosed with this disorder.
Bipolar disorder is a disorder of the brain and is also called manic-depressive illness. Due to this disorder, the affected individual experiences abnormal mood shifts, unusual levels of energy and activities and atypical ability to perform tasks of daily life. As far as symptoms of bipolar disorder are concerned, they are rather severe in nature. They are not like the usual ups and downs experienced by people once in a while. Bipolar disorder has been found to cause serious damage to relationships, poor performance (academically or professionally. It can even cause patients to attempt suicidal actions. However, the good thing is that there is treatment available for bipolar disorder. For this reason, a number of people have been able to lead contented and productive lives after receiving the appropriate medications and treatment. The development of bipolar disorder often takes place during late adolescent or early adult years. The facts and figures reveal that a majority of people experience the symptoms of bipolar disorder before reaching the age of twenty-five ("Bipolar Disorder").
Bipolar disorder is a disabling illness, with its extreme mood swings from depression to mania. Bipolar used to be called manic depressive disorder. Bipolar disorder is very serious and can cause risky behaviors, even suicidal tendencies. It can be treated with therapy and medication, but can lead to damaged relationships, social life and careers if it 's not treated. Some patients
The Bipolar disorder (AKA) manic depression is a common and debilitating mood disorder which causes extreme shifts in energy and mood. The word bipolar means that the two main polar extremes in which a person with the disorder experiences. According to part of the National Institutes of Health that watches over neurological and psychological research this disorder affects about 2.1 million adults in the United States and about 1 percent of the entire world. The first signs of this disorder usually appear in childhood and early adulthood, with cases rarely happening in childhood, no discoveries have been
Bipolar disorder represents a group of diseases that affect the brain and cause dramatic mood swings from one extreme to the other. Feelings can move from depression to mania, from the lowest of lows, to the highest of highs. This disorder is not curable, but through a comprehensive treatment plan it can be controlled. According to the National Institute of Mental Health (NIMH), 5.7 million adults in America are impacted by this disorder. That equates to 2.6% of the population over the age of 18 every year. 250 million people worldwide are estimated to have bipolar disorder and more than two-thirds have one or more family members that have a mental illness. That is why the National Institute of Mental Health has indicated that bipolar disorder may have an inheritable component to the disease. The risk is low only between 0.5 and 1.6%, but the disorder is one of the most devastating, with a suicide rate of 10 to 20% among patients (Huffman/Dowdell).
We ask ourselves what causes Bipolar disorder and what the effects are. There are about approximately 5.7 millions Americans suffering from bipolar disorde r. Many people only have a surface understanding of the disorder that is garnered from television and articles in popular publications. The best way to help yourself or anyone you know that have this condition is
The evidence found within the literature suggests that a serious problem in the United States is the inappropriate treatment of bipolar disorder (Merikangas, Akiskal, Angst, Greenberg, Hirschfeld, Petukhova, & Kessler, 2007). According to Merikangas et al., (2007), the leading cause of premature mortality as a result of suicide and associated medical conditions is bipolar disorder. This population is also at an increased risk of unfavorable outcomes due to their recurrent periods of mania, depression and psychotic episodes combined with their substance use and unstable living environments (Kilbourne, Bauer, Pincus, Williford, Kirk, & Beresford, 2005). Patients with bipolar disorder may also be at risk for being under-diagnosed and/or misdiagnosed. Researcher have learned that patients diagnosed with bipolar disorder have actually had Borderline