Chemical Evaluation Of Zinc Effects At 5 Ht1ar And Serotonin Neurotransmission

830 WordsOct 30, 20164 Pages
Our present study represents a further pharmacological evaluation of zinc effects at 5-HT1AR and serotonin neurotransmission in the context of zinc antidepressant-like activity. Since the role of postsynaptic 5-HT1AR in the pathophysiology of depression and in the action of antidepressants is widely discussed in the literature (see [9] for review), our present study evaluated the effect of zinc at postsynaptic 5-HT1AR in the PFC and Hp of rats after acute and chronic zinc treatments. Neither acute nor chronic zinc treatment induced significant changes in 5-HT1AR mRNA in the PFC or Hp (Fig. 1a, c). However, chronic zinc treatment increased protein levels of 5-HT1AR in the Hp by 78% (t=3.137, df=14, p=0.007) relative to control rats (Fig. 1d). Discrepancies between 5-HT1AR mRNA and protein expression levels in different brain regions have been reported in animal stress models. Iyo et al., 2009 observed increased 5-HT1AR mRNA level and decreased protein level in the PFC [6]. Our earlier animal studies showed no changes in 5-HT1AR mRNA in the PFC of female rats subjected to prenatal stress, in pregnant stressed female or in the Hp of male rats subjected to chronic mild stress [15]. However, 5-HT1AR protein levels were reduced in these groups of rats [15]. Shishkina et al., 2012 [12] reported an increase in 5-HT1AR gene expression in the PFC of rats exposed to FST; this effect was reversed by chronic fluoxetine treatment [12]. However, in the non-stressed rats, fluoxetine

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