Chronic Cough And Reflux : Is Esophageal Motility The Key?

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General Study Information

Principle Investigator: Lesley A Houghton, Professor of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Florida
Study Title: Chronic Cough and Reflux: Is Esophageal Motility the Key?
Co-Investigator(s):
Respiratory Research Group
University of Manchester, UK
Jaclyn A Smith, MRC Clinician Scientist and Reader, University of Manchester, Consultant Pulmonologist, University Hospital of South Manchester NHS Foundation Trust; Visiting Scientist, Mayo Clinic, Florida
Division of Gastroenterology, Mayo Clinic, Florida, USA Kenneth DeVault, Chair of Internal Medicine, Professor of Medicine and Consultant Gastroenterologist
Anupong Tangaroonsanti, Visiting Scientist, Mayo Clinic, Florida
Division of Pulmonology, Mayo Clinic, Florida, USA Augustine Lee, Assistant Professor, Consultant Pulmonologist
Statistician:
Protocol version number and date:

Purpose
Abstract:
Background: Chronic cough (CC) is not uncommon condition that impacts on patient’s quality of life, physical and psychosocial status. There are various causes of CC i.e., tobacco smoking, air pollution exposure, chronic pulmonary infection, asthma, chronic obstructive pulmonary disease, gastroesophageal reflux disease, postnasal drip syndrome and rhinosinusitis. Interestingly, the recent publication demonstrated that weak peristalsis with large breaks (WPLBs) which is one of the esophageal dysmotility was remarkably found in patients with

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