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Diagnosis Requires A Positive Result From An Initial Hiv Antibody?

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TERMINOLOGY
CLINICAL CLARIFICATION 1
• Diagnosis requires a positive result from an initial HIV antibody or combination antigen/antibody test plus an accompanying or subsequent positive result from a supplemental HIV test different from the initial test 1
• Current guidelines suggest using a Fourth generation assay that detects HIV p24 antigen AND HIV antibodies 19 o Positive results are confirmed by an HIV-1/HIV-2 differentiation immunoassay
- If the differentiation immunoassay is indeterminate or negative, plasma HIV RNA level ("HIVviralload") should be checked. o Note that these current guidelines differ from the classic approach of first testing with a third generation antibody test, an enzyme immunoassay (EIA), and then confirming …show more content…

(2 or more episodes in 12 months)
- Esophageal candidiasis
- Invasive cervical carcinoma confirmed by biopsy
- Disseminated or extra pulmonary coccidioidomycosis
- Extrapulmonary cryptococcosis
- Chronic intestinal cryptosporidiosis (>1 month in duration)
- Cytomegalovirus disease (other than liver, spleen, or nodes)
- HIV-related encephalopathy
- Herpes simplex virus characterized by chronic ulcers (>1 month in duration), or bronchitis, pneumonitis, or esophagitis

- Disseminated or extra pulmonary histoplasmosis
- Chronic intestinal isosporiasis, (>1 month in duration)
- Kaposi sarcoma
- Lymphoma (Burkitt, immunoblastic, or primary central nervous system)
- Disseminated or extra pulmonary Mycobacterium avium complex (MAC) or Mycobacterium kansasii
- Pulmonary or extrapulmonary Mycobacterium tuberculosis
- Disseminated or extra pulmonary Mycobacterium, other species or unidentified species
- Pneumocystisjiroveci (formerly carinii) pneumonia (PCP)
- Progressive multifocalleukoencephalopathy (PML)
- Recurrent (nontyphoid) Salmonella septicemia
- Toxoplasmosis of brain
- HIV wasting syndrome (involuntary weight loss >10% of baseline body weight) associated with either chronic diarrhea (two or more loose stools per day For 1 month) or chronic weakness and documented Fever For 1 month

DIAGNOSIS
CLINICAL PRESENTATION
• History o Greater than 50% with acute HIV infection develop symptoms, although timing and duration are variable 4
- Acute illness develops within 1-4 weeks

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