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Disadvantages Of Fentanyl

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• The article seeks to determine a method that can be used to differentiate fentanyl in illegally produced substances, which is increasingly important to modern society due to the opioid epidemic spreading across the United States. • The article hypothesized that deriving fentanyl into two vinylogous amines and producing a chromatogram of these products would allow for easy differentiation between various homologues and analogues of fentanyl. This study is differentiating between several types of fentanyl for analysis, which I will be doing in my project to analyze for purity level and degradation. • In the proposed method, the sample solution is dissolved in acetonitrile with (1 mg/mL of an analog of fentanyl (CH2CH2CH2) as an internal standard) so that the sample solution is at a concentration of 0.1mg/mL. 1mL of the acetonitrile solution is placed into a centrifuge with 50mg of 4-DMAP (4-(dimethylamino)-pyridine) and 50microL of HFBA (heptafluorobutyric anhydride). The solution is allowed to react for 1h at 75C, following which 5 mL of isooctane and 1N of aqueous sodium carbonate are added, and then centrifuged. 1 mL of this layer is then diluted using 10 mL isooctane. 5 mL of this dilution is placed in a centrifuge tube and back extracted using 5mL of 1 N sulfuric acid. The solution is then ready to be chromatographed. If the sample solution is adulterated with sugars, prior to dissolving the solution in acetonitrile, dissolve an amount equivalent to .1 mg of fentanyl in
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