Does Down Syndrome Increase the Chances of Developing Leukemia?

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Down syndrome is a genetic disease that occurs in people that have 47 chromosomes instead of 46. Does the Down syndrome increase the chances of developing leukemia? What health risks are involved in trying to keep children from getting leukemia? I have personally seen the effects of Down syndrome. There have been clinical trials that have shown the results of leukemia on kids with Down syndrome. The life expectancy has gone up dramatically because of medicine. Down syndrome has affected the lives of many and psychologists are still looking for answers to solve the disease. Children with Down syndrome or what they call trisomy 21 have a markedly increased risk of leukemia in childhood but as later on in adulthood its has less of a chance …show more content…
Down syndrome is a genetic disease that occurs in people that have 47 chromosomes instead of 46. Does the Down syndrome increase the chances of developing leukemia? What health risks are involved in trying to keep children from getting leukemia? I have personally seen the effects of Down syndrome. There have been clinical trials that have shown the results of leukemia on kids with Down syndrome. The life expectancy has gone up dramatically because of medicine. Down syndrome has affected the lives of many and psychologists are still looking for answers to solve the disease. Children with Down syndrome or what they call trisomy 21 have a markedly increased risk of leukemia in childhood but as later on in adulthood its has less of a chance of happening. Children that acquire Down syndrome have a genetic mutation in the gene called GATA1. Trisomy 21 is the most observed abnormality seen at birth and occurs in about 1 to 700 individuals. Children that are born with Down syndrome have an increased risk of acute megakaryoblastic leukemia (AML) and also acute lymphoblastic leukemia (ALL). In studies it shows that approximately 4-5% of children that are born with Down syndrome are also born with transient myeloprolifative disorder (TMD), a clonal preleukemia characterized by an accumulation of immature megakaryoblasts in the fetal liver and peripheral blood (Mailnge 2012). Acute Myeloid Leukemia develops when acquired changes in DNA of a developing marrow cell that which can turn

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