Does Down Syndrome Increase the Chances of Developing Leukemia?

The aetiology of Downs syndrome which means the cause of a specific disease (Mcferran, 2014). Suggests that when one of the chromosomes in reproduction do not separate properly this is when Down’s Syndrome is caused (Steven, 2005). This extra chromosome causes physical developmental defects this causes reduced muscle tone, a small mouth with a projecting tongue and eyes that slant downwards and upwards and causing the back of their head to be flat. Many babies born with Down's Syndrome are diagnosed with the condition after birth and are likely to have many physical defects for example they may have reduced muscle tone, eyes that slant upwards and outwards, a small mouth with a protruding tongue and a flat back of the head. (Hartley, 2015). Down Syndrome patients can also be afflicted with other conditions, including heart disease, Alzheimer’s disease, and leukemia (WHO, 2010). This could effect children and adults through out their life also effecting their physical and mental health.

The table below will summarize the physiological aspects as well clinical manifestations shown in AML.

Therefore, the adequacy of primary therapy is an important factor to be considered in deciding on the subsequent clinical care of these patients, which raises the question of whether the majority of patients who are successfully salvaged by second line standard chemotherapy for relapsed AML are those who were suboptimally treated in the first line due to assigned protocol, toxicity, complications or other factors ( Giles et al

As Leukemia cells build up in the marrow, they can crowd out the normal blood cell-making cells. The Leukemia cells might also invade other areas of the body, which can also cause symptoms. A few symptoms of Leukemia are tiredness, coldness, weakness, feeling dizzy or lightheaded, headaches, and shortness of breath and pale skin. If you have low blood plate counts you could also have bone or joint pain, swelling of the abdomen, loss of appetite or weight loss, swollen lymph nodes, coughing or trouble breathing, swelling of the face or arms, headache, seizures or vomiting, rashes, gum problems, extreme fatigue, and weakness. Children who receive therapy for all types of Leukemia may also experience their own symptoms, which may include late adverse effects, which are central nervous system (CNS) impairment, slowing of growth, infertility, cataracts, and an increased risk for other cancers. These effects vary on the person’s age during the treatment, and the type of therapies that they

Down syndrome is caused by an extra chromosome of 21 in the children’s cell. Normally people have 46 chromosomes, however down syndrome contains 47 chromosomes. (Nhs.uk, 2016i)

Down syndrome (also known as trisomy 21) is a disorder that makes you physically and mentally more challenged than everyone else but you are still able to grow develop and live a partially normal life. The major causes of Down syndrome are first just getting unlucky and having the 21st chromosome be irregular. But if you have a child when you are older than 35 you have a highly increased chance of getting down syndrome also if you have a sibling with Down syndrome or another kid with-it that can also increase the chance of getting down syndrome. Some symptoms of this disorder are, you can be physically less capable than others can and can have a hard time remembering things and can possibly not be able to achieve what seems to be easy things to do daily. However, most important, they only live to about 80. In addition, they can have a hard time reproducing but can still can reproduce.

Certain children are at a higher risk for Leukemia than others. The risk of Leukemia increases if your child has an inherited disorder such as Down Syndrome,

Down syndrome is a disease in which chromosome 21 has extra genetic material delaying the way a child develops mentally and physically.

The second leukemia is acute myelogenous leukemia. AML is also a fast spreading leukemia which affects "not yet mature" cells. Acute myelogenous leukemia is caused by damaged cells in the bone marrow. It is caused by production of immature cells. AML mostly affects older people over sixty-five years old. It's mostly found in males who are smokers or have blood disorder.

Down syndrome (known as Trisomy 21) is a genetic disorder caused when cell division results in extra genetic material from chromosome 21. This genetic disorder occurs in about 1 of 800 live births. Down syndrome was first characterized a separate form of mental disability by John Langdon Down in 1862. By the 20th century the disability had become the most recognizable form of mental disability. These individuals have gone through a lot. In ancient times, many infants with this disability were killed or abandoned. The people with Down syndrome used to be called Mongolian idiots and the syndrome was called mongolism. This comes from the people thinking that Down syndrome individuals resembled Mongolians. It doesn’t only affect the individual

Down syndrome is a genetic disorder and the most common autosomal chromosome abnormality in humans. Down syndrome occurs when an individual has a full or partial extra copy of chromosome 21. This additional genetic material alters of development and causes the characteristics associated with Down syndrome. The primary purposes of this article are to: establish the origin of the term Down syndrome; determine the possible causes of Down syndrome; Likelihood of having a child with Down syndrome; and treatments for humans diagnosed with Down syndrome.

of babies born with Down syndrome elevated by about 30 percent. The risk of a child having

In Down syndrome, a person most often inherits two copies of chromosome 21 from the mother and one chromosome 21 from the father for a total of three chromosomes 21. If a baby inherits the chromosome with the extra genes from chromosome 21, then the child will have Down syndrome. About 2% to 4% of people with Down syndrome inherit additional genes from chromosome 21, but not in every cell of the body. These individuals may, for example, have inherited extra genes from chromosome 21 in their bone marrow causing an abnormal increase rate of blood cell production which is the cause of Leukemia Cancer. (Schainman 36)

The authors of this study reported on the symptoms in acute lymphocytic leukemia. Acute lymphocytic leukemia is a more deadly, and rapidly growing form of leukemia. Flu like symptoms such as fever, fatigue, and night sweats are key symptoms of the disease, but ear problems are more common with acute lymphocytic leukemia.

Down syndrome is a chromosomal condition that affects 1in every 700 kids. Down syndrome is when a child has and extra copy of chromosome 21. Down syndrome has many ways of telling if the child has down syndrome, like physical features. You can also tell if a child has down syndrome based on how they act. There are different ways of obtaining down syndrome. Kids with down syndrome are no different than kids that were born with the normal set of chromosomes, they just act a little different and need a little bit more help.