Effect Of Cell On Cell Mortality

1455 Words Apr 4th, 2016 6 Pages
Introduction
Cell differentiation is the process that leads generalized cells to change patterns of gene expression and move towards the phenotype of specialized cells. Terminal cell differentiation occurs when a cell reaches its final specialized characteristics, and is usually where the cell permanently ceases division (Alberts et al. 2008). Some cell lines can be used to study differentiation. For instance, the PC-12 cell line differentiates in response to nerve growth factor by extending neuritic outgrowths from the cell body (Das et al. 2004). Nerve growth factor (NGF), a neurotrophin that regulates cell differentiation, plays an important part in various pathways and signals (Sofroniew et al. 2001). For instance, NGF plays an important role in cognitive functioning, and disruptions in signalling pathways that can contribute to the development of neurological degenerative diseases such as Alzheimer’s (Wigerius et al. 2013). Although varying concentrations of NGF have been reported to alter the amount of differentiation in PC-12 cells, the effect of NGF on cell mortality has not been determined (Tischler and Greene 1975).
PC-12 is a cell line that was developed in 1976 by Greene and Tischler. A single chromaffin cell was isolated from a tumor in an adrenal gland of the medulla in a brown rat. Chromaffin cells are neuroendocrine cells, which release hormones in response to signals from the nervous system. Chromaffin cells in particular release the neurotransmitters…
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