In discussing epilepsy pathology, it is imperative to discuss mesial temporal sclerosis (MTS) and focal cortical dysplasia (FCD). As these topics are covered in the Pathophysiology chapter of this book, they will not be covered in detail in this chapter. It is worth noting, however, that it is essential for the epileptologist to be able to readily identify the radiographic findings associated with these disorders, such as decreased hippocampal volume and increased T2/flair signal in MTS, and the transmantle sign in FCD. These findings are not only key in the diagnosis of these disorders, but also in surgical planning and prognostication of surgical outcome, in which MTS has been shown to be significantly where the abnormality can be visualized in MRI as compared to cases in which the MRI is normal. Another important point about MTS is that there is currently an unresolved debate regarding whether the pathological findings are the cause of the seizures or the result of seizures, and many are in the opinion that both of these elements may be at play, suggesting that the disease process is a self-perpetuating cycle that can be disrupted by early and aggressive treatment. This chapter will discuss pathology as it pertains to some of the many other causes of epilepsy. These include neoplastic and other mass lesions such as vascular anomalies, neurocutaneous syndromes, infectious and inflammatory causes, cortical malformations, chromosomal causes and metabolic causes. NEOPLASMS
Seizures or epilepsy are brain disorders where the person has repeated convulsions over a period of time. They’re episodes of disturbed brain activity that cause changes in attention and behavior. Seizures are considered the most common observed neurological dysfunction in children. They are very sudden intermittent episodes of altered consciousness lasting seconds to minutes and include involuntary tonic (stiffening of muscles) and clonic (altering contraction and relaxation of muscles) movements.
underlying cause can be determined. Seizures occur as a result of abrupt, explosive, unorganized discharges of cerebral neurons. This causes a sudden alteration in brain function involving sensory, motor, autonomic and/or psychic clinical manifestations.
Dzevdet Smajlovic, professor from the Department of Neurology at the University of Tuzla in Bosnia stated that
Epilepsy is due to an upset in brain chemistry, which means that the messages that travel between nerve cells or neurons become scrambled. Because of this, the activity of neurons is disturbed and results in a seizure or loss of consciousness. Many types of seizure can occur and epilepsy can affect anyone at any age.
How attention was brought to epilepsy. First, 2.3 million people have epilepsy in America and one in twenty-six people can get epilepsy in their lifetime (“Facts”). The future of research for seizure disorders are focused on brain imaging. Epilepsy can run in the family, can cause head injuries, alcohol abuse (“Multiple”), and driving can be dangerous (Haugen 22).
Epilepsy and Seizure Disorder: All actions and functions travel to the different parts of the brain much like electrical wiring. The “electricity” moves from one area or wired circuit through another by jumping and traveling from area to area much like electricity Due to abnormal electricity and “jumping” seizures can occur. Epilepsy is where these electoral abnormalities are reoccurring often causing many seizures. The Tonic-Clonic or Grand Mal seizures that CM has is from muscles tightening and relaxing very fast due to the abnormal jumping of electricity in the brain. P. 417
Seizure is the physical finding that occurs after abnormal electrical activities in the brain. Patients with seizures could have symptoms like changes in one’s behavior, drooling, frothing at the mouth, irregular eye movement, grunting and snorting, incontinence, extreme changes in mood, shakes, sudden falls, abnormal changes in taste buds, clenching teeth, respiratory arrest, uncontrolled muscle spasms, twitching, and brief blackout follow by period of confusion where they don’t remember anything (Seizures: MedlinePlus Medical Encyclopedia). Seizures also have many underlying etiology such as abnormal sodium or glucose levels in the blood, brain infections, brain injuries, brain tumor,
Any type of brain disease can cause epilepsy; it also can develop as a result of brain damage from other disorders. For example, brain tumors, alcoholism, and Alzheimer's disease often cause epilepsy because they change the way brain usually works. Strokes, heart attacks, and other conditions that deprive the brain of oxygen also can sometimes cause epilepsy. Other more rare causes of epilepsy are prenatal injuries that come about from poor nutrition or maternal infections; poisoning by lead or carbon monoxide; or overdose of prescription antidepressants or street drugs. There are still many patients for whom the cause of their epilepsy cannot be identified (idiopathic epilepsy).
People uneducated about Epilepsy may have confused thoughts on what it really is. People have these "notions," which are partly or entirely not true. So, throughout this research paper, these notions will be proven untrue, mostly by factual information given by
Although seizures have been characterized for a long time, they are continually redefined by the International League Against Epilepsy (ILAE) to better characterize those arising from due to standalone structural neurologic disorders (i.e., epilepsy), versus those that are secondary to an existing illness (e.g., febrile types seen in cases of infection), among others1. In this literature review, the focus is on febrile seizures (FS) in pediatric groups and the pathogens most often associated with them. However before delving into a discussion about the pathogens associated with FS it would be appropriate, at this moment, to delineate the criteria that characterize a febrile seizure. Currently, complex FS are described as one that arises in one side of the brain (that is, it’s focal), occurs more than once during a febrile illness within a 24-hour period, or lasts more than 10-15 minutes.2 My febrile patient suffered a similar episode also presented with had initially
For anyone in their adolescence, going through school, memory is a key factor to success. Though epilepsy can be diagnosed at anytime, it is most commonly diagnosed to young children who usually outgrow it post-adolescence. Unfortunately, issues with memory are the most commonly reported cognitive problem with epileptics. It’s also found that issues with memory could also be a result of the cause, course, or treatment of epilepsy. Issues with memory have been recorded in higher frequency with children diagnosed with temporal lobe epilepsy (TLE). There are several studies that claim to show evidence that memory problems exist amongst other epilepsy syndromes, such as frontal lobe epilepsy (FLE), idiopathic generalized epilepsy (IGE) including
Epilepsy, also called seizure disorder, chronic brain disorder that briefly interrupts the normal electrical activity of the brain to cause seizures, characterized by a variety of symptoms including uncontrolled movements of the body, disorientation or confusion, sudden fear, or loss of consciousness. Epilepsy may result from a head injury, stroke, brain tumor, lead poisoning, genetic conditions, or severe infections like meningitis or encephalitis. In over 70 percent of cases no cause for epilepsy were identified. About 1 percent of the world population, or over 2 million people, are diagnosed with epilepsy.
Brain tumors can be a cause of seizures also, but these are very rare. Most epileptic patients have been tested for brain tumors, just
BACKGROUND. 4 to 10 out of every 1000, totaling to 50 million people around the world suffer from epilepsy. Around 80% of these patients are found in the developing countries, Pakistan being one of them [1]. 60% of patients with this chronic neurological malady are labeled as having an idiopathic origin worldwide. In Pakistan the prevalence of epilepsy is 9.99 per 1000 of general population [2], with 21% to 76% having an idiopathic origin. Here too, like the rest of the world the commonest type is Generalized Tonic Clonic Epilepsy [3].
Neurophysiological scatters are another method for Inclining Elements to Outrage and Hostility a few issue or conditions happens to the cerebrum have been included in comprising animosity and strange conduct like Transient projection epilepsy, Worldly flap epilepsy is an unending neurological condition portrayed by more than once, ridiculous epileptic seizures which start in the fleeting projection of the mind. The seizures include tactile changes; for instance, noticing an unordinary smell that is not there, or unsettling influence of memory, and change in practices