Esophageal Manometry And Ph Impedance Studies

1973 Words Mar 16th, 2015 8 Pages
Esophageal Manometry and pH-Impedance Studies in Gastro-Esophageal Reflux Disease
The first attempts at measuring the pH changes in Gastro-esophageal reflux disease (GORD) were made by Tuttle et al, who in 1960 used a glass pH electrode to demonstrate a gradual sloping gradient in the gastro-esophageal pH gradient in patients with esophagitis in contrast to a sharp one in normal subjects(1).Later, Johnson and DeMeester developed a dependable external electrode in 1974, successfully using it to measureesophageal pH changes for up to 24 hours(2). During the last decade, further studies demonstrated thatthe use of combined pH-impedance monitoring was more effective compared to pH monitoring alone in clinical practice.
Kronecker and Meltzer performed the first esophagealmanometric studies using a balloon kymograph in 1894, but its clinical use was demonstrated by an atlas of esophagealmanometry published by Code et alin 1958(3). When optimally utilized, a manometric evaluation provides an accurate description of esophageal contractile function, and is useful in characterizing a variety of esophageal motility disorders.
These rapidly evolving and highly technical fields of study have provided major insights into our understanding of the pathophysiology of GORD, and have become an integral part of its evaluation in the modern era.
Intra-esophageal acidity can be measured via a trans-nasal catheter with a pH sensitive electrode placed in…
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