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Ethical Issues In Genetic Research

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As the effects of genes on human physiology and disease are increasingly being examined in laboratories and clinics across the world, the discussion surrounding informing the family members of tested patients needs to be explored. Previous research has discovered that certain genetic mutations can predict with a high degree of accuracy the rate of occurrence of disease not only in the tested participant but in the family as a whole. One such genetic mutation is a change in the Adenomatous Polyposis Coli (APC) gene and a corresponding increase in the rate of occurrence of Familial Adenomatous Polyposis (FAP). Researchers need to address the question of whether or not to inform the family members of a participant if one of these genes is discovered. In this paper, we discuss whether the researchers have the ethical responsibility to inform the family of a tested participant’s APC status and the implications that will …show more content…

These adenomatous colorectal polyps will eventually develop into colorectal cancer if a prophylactic colostomy is not completed [2]. FAP affects both sexes equally with an incidence rate of 1/8300 [3]. A mutation in the APC gene causes 60% of FAP [4]. In people with the APC mutation there is an almost 100% chance colorectal cancer will appear by the age of forty years without treatment [5]. FAP is an autosomal dominant syndrome, and thus the offspring of an affected parent has a 50% risk of inheriting the defective APC gene [3]. With genetic testing of his parents, a child’s risk of developing late-stage cancer is significantly reduced due to the increased detection of early stage polyps [6]. Due to this, the psychological, moral and ethical issues associated with genetic testing and the subsequent reporting of the results to the family members of those tested must be considered due to the ethical dilemmas this

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