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Exposure In Domestic And Laboratory Animals Lab Report

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Exposure in domestic and laboratory animals In among the food crops peanut meal is considered as the most contaminated feed by aflatoxin. These are consumed by the animal’s thus lead those to hazardous effects. Contaminations of the feeding meals are mainly caused due to mold metabolites. These metabolites produce carcinogenic effect in rat, ferret, trout and duck. Mainly the organ affected by aflatoxicosis is liver by both short-term and long-term exposure. Symptoms like anorexia, icterus, rapid weight loss, exercise tolerance, depression, fever, ataxia, gastrointestinal damage etc. will prevail in animals by aflaoxicosis. IN BIRDS During the early intoxication caused by aflatoxin birds die due to venous congestion and sever peri-portal …show more content…

Due the effect in liver cells they are enlarged and later results in fatty depositions and changes that lead to increase in connective tissue, progressive biliary proliferation and scattered liver necrosis. The other one effect is the aggregation of lymphocytes and polymorphonuclear leukocytes in the portal tracts. as a result of this action few weeks after the exposure lymphocytic hyperplasia, fibrosis and biliary proliferation is occured. Due to the aflatoxin toxicity mitochondrial injury is indicated in the liver cells where a drastic reduction in activities of enzymes such as succinate dehydrogenase, malatedehydrogenase and isocitrate dehydrogenase is noticed. This causes the impaired liver function in chicks due to the Aflatoxin B1 poisoning. So liver mitochondrial injury is considered as one of the dominant characteristic of aflatoxin toxicity. Not only in chicks but also ducklings also a lysis of mitochondrial membrane is reported. Broiler chicks more prone to aflatoxicosis than poultry chicks. IN CATTLE'S Incattle's aflatoxin toxicity had been determined on the basis of consumed peanut meal and other contaminated feeds by AFB1. Here also the major organ affected is liver. Venoocclusive disease and fibrosis with biliary proliferation had been exhibited in the affected hepatic cells. Many pathological alterations had reported through various studies conducted. Continuous exposure of aflatoxin has also been described about increased connective tissue,

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