Fragile X Research Paper

Around 1 in 400 to 6000 females in the world are also born with the full mutation and will show features of the disease. On the other hand, roughly 1 in 800 men and 1 in 260 women in the world are carries of the Fragile X pre-mutation. Furthermore, a recent 2004 analysis indicates that the quantity could be as high as 1 in 130 women, which shows that there may be a rapid increase of carriers of the disease (The National Fragile X Foundation, 2011).

Fragile X Syndrome is a genetic condition. FXS causes learning and behavioral challenges, intellectual disability as well as a variety of physical characteristics. Although Fragile X Syndrome can occur in males and females, males are affected more frequently than females are; furthermore, males with FXS generally experience characteristics with a greater severity than females with the condition do.

The gene is mutated and it affects more males than females. Individuals with Fragile X have a large number of defects and disabilities including physical, cognitive, and neurobehavioral features (Jewell, J., 2004). This disability is caused by a gene that inactive which is the X chromosome. There is no known cure, yet, options are available to those who have this disorder. Individuals may receive speech therapy, physical therapy, and psychological services. For children attending school they may qualify for special education. Delays in cognition and learning are often associated with this syndrome. That's why; learning can be more challenging for these individuals. The impairments differ for those impacted with the syndrome. Accommodations are essential in order to meet the needs for each

Quercia, N., MS, CCGC, CGC, & Alic, M., PhD. (2016). Fragile X Syndrome. In T. Moy & L. Avery (Eds.), The Gale Encyclopedia of Genetic Disorders (4th ed., Vol. 2, pp. 712-715). Farmington Hills, MI: Gale. Retrieved from

Fragile X syndrome is among the common inherited cause of intellectual disability and single cause of autism. This is caused by the lengthening of the X chromosome and although both male and female can be affected, males are more prone to be affected than females – with the ratio of 1/4000:1/8000 (1). This is because males have only one X chromosome, while female has two. Females can be a carrier of this gene defect but their other X chromosome would still be able to make the protein, whereas male, only possessing one X chromosome would be more affected. Symptoms of this mutation includes behavioral and learning disabilities, autism disorder, elongated and narrow face (macrocephaly), macroorchidism

Fragile X Syndrome is the most common known cause of inherited learning disability, affecting one in 4,000 men or boys and one in 6,000 women or girls. People with Fragile X Syndrome can have mild to severe learning disabilities. Their speech and language development may be delayed and they can experience anxiety in social situations. Behaviours associated with Fragile X can include a short attention span, impulsiveness, overactivity, dislike of eye contact, difficulty in relating to other people, the need for a familiar routine, repetitive speech and hand flapping or hand biting. Some of these are similar to difficulties that autistic people may experience. However, autism and Fragile X Syndrome are two different diagnoses. Some people are

Fragile X is a genetic condition involving changes in part of the X chromosomes, it is the most common form of inherited intellectual disability in boys. Often called the most common disease you never heard of. It was discovered by Martin and Bell in 1943. Effects of this disorder can be, Physical development where the physical facial appearances will appear after puberty and the more they age. Also, mental ability like people with this disorder could have some behavioral problems for example, problem talking, hard to be social, and mental retardation. Overall people with this disorder health can be affecting the way they learn, how they communicate, and how they act. It is more common in males. Every 1 in 4,000 males will have this and 1 in

Fragile X Syndrome is a genetic condition that causes intellectual disabilities, various physical characteristics and challenges to learning as well as behavioural issues. It effects both genders but majority of the time it will affect males more. There is still no cure, although finding the genetic condition early you can get help from professionals to make sure that people with Fragile X Syndrome can live up to their full potential.

(i) The fragile X syndrome (FXS, MIM 309550). It is an X-linked dominant disorder with early onset, with diminished penetrance and prevailing cause of inherited mental retardation (Garber et al., 2008). Other disabilities appear sometimes associated, like intellectual and emotional issues, mood instability, learning difficulties and autism. Furthermore, specific characteristic phenotypical features may coexist, like macroorchidism, elongated face and uncommon hyperextensibility of fingers.

Fragile X is the most common single gene which leads to autism and other intellectual disabilities. Fragile X is transmitted through DNA. Within the DNA, it has been found that the

Fragile x syndrome, also referred to as Martin-Bell syndrome or Marked X Syndrome, is one of the most common forms of inherited mental retardation. Fragile X Syndrome is a genetic condition that causes a range of developmental issues. The syndrome starts to affect people around the age of 2. Although women can also be affected by this syndrome, most of its affected population consists of men. The female carrier status of Fragile X Syndrome has been estimated to be as high as 1 in 130-250 population. Fragile X syndrome has many effects on the research of the past, affected people of the present, and medications of the future.

Fragile X syndrome, also called Martin- Bell syndrome or Marker X syndrome is an incurable genetic condition characterized by inherited mental retardation, intellectual disability and learning disabilities. This is considered the second most common cause of genetically associated mental deficiencies, after trisomy 21. A notable feature of this disorder is that the penetrance shows an increase tendency with passing generations. Although this genetic disorder is incurable, life expectancy is not affected in people with fragile X syndrome because there are usually no-life threatening health issues associated with this disorder. Fragile X syndrome is predominant in boys who present with some level of intellectual disability than in girls who may present only with some learning disability. Per statistics from www.emedicine.medscape.com, conservative estimates are that fragile X syndrome affects about 1 in 2500 -4000 males and 1 in 7000 – 8000 females. It also stated that the prevalence of female carrier status has been estimated to be as high as 1 in 130 – 250 population, the prevalence of male carrier status is estimated to be 1 in 250 – 800 population.

Congratulation! You’re expecting a child! Both you and your partner are thrilled that you got a child, but until doctor say you that your child has Fragile X Syndrome. Fragile X syndrome the disease that was passed down from your parents to children through their genes. However, it’s causes logical and developmental disabilities.

What is Fragile X? “This is a genetic condition that causes learning disabilities, behavioral problems and many different physical characteristics”.

“Nearly all cases of fragile X syndrome are caused by an alteration (mutation) in the FMR1 gene where a DNA segment, known as the CGG triplet repeat, is expanded” (National Human Genome Reasearch Institution, 2013). Even though it affects both males and females, females usually have a milder case. The FMR1 (fragile x mental retardation 1) makes a protein, called fragile X mental retardation protein. People that have fragile X, do not produce this protein. Both