Henry Molaison Case

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Introduction Henry Molaison, who is best known for H.M, was probably the best known single patient in the history of neuroscience. His severe memory impairment, which resulted from experimental neurosurgery to control seizures, was the subject of study for five decades until his death in December 2008. In 1953, neurosurgeon William Beecher Scoville performed a bilateral mesial temporal lobe resection on patient Henry Molaison, who suffered from epilepsy. The operation was novel as a treatment for epilepsy and had an unexpected consequence: a severe compromise of Molaison's anterograde memory. Henry Molaison The Man with No Memory Born on February twenty-six, 1926, Henry Molaison or better known as H.M, was a healthy young …show more content…

Neurosurgeon, William Scoville localized Malison’s epilepsy to his left and right medial temporal lobes. As a treatment, Scoville suggested surgical resection. The resection included the hippocampal formation and adjacent structures. Moreover, the resection also included most of the amygdaloidal complex and entorhinal cortex. The remaining of hippocampal tissue appeared to be a complete waste of the body, leaving the hippocampi entirely nonfunctional. In addition, the entire entorhinal cortex was also destroyed along with some of his anterolateral temporal cortex. The goal to control Henry epilepsy was successful; however, it developed severe anterograde amnesia. Although his working and procedural memory were intact, he could not form new events to his explicit memory. Explicit memory is defined to be the recollection of previous experiences and information which is often used throughout the day. Additionally, Henry had also developed retrograde amnesia, which caused him to not remember most events in a one-two year period before surgery or even some events up to ten years before. His ability to form long-term procedural memories was intact. H.M was capable to learn new motor skills, despite not being able to remember learning

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