Hepatitis C is a liver disease caused by the hepatitis C virus (HCV), which can cause both acute and chronic hepatitis infection, which are the two major types of hepatitis C. Ranging in seriousness from a mild illness lasting a few weeks to a major illness that can last a lifetime, hepatitis c often leads to inflammation of the liver. It is a problem in the United States and worldwide, mostly affecting Africa and Central and East Asia. HCV is responsible for 500,000 liver related deaths each year, is the most common bloodborne pathogen, and is a leading cause of liver transplantation. More than 4 million people in the Unites States are infected and most are not even aware of their diagnosis. Also, death due to HCV infection is the most …show more content…
Genotype 1 is the most common type of Hepatitis C genotype in the United States and the most difficult to treat. Knowing the genotype of Hepatitis C is helpful in making a therapeutic recommendation. Individuals with genotypes 2 and 3 are almost three times more likely than individuals with genotype 1 to respond to therapy with alpha interferon or the combination of alpha interferon and ribavirin. Furthermore, when using combination therapy, the recommended duration of treatment depends on the genotype. For this reason, testing for Hepatitis C genotype is often clinically helpful. Once the genotype is identified, it need not be tested again as genotypes do not change during the course of infection.
Although there are many ways hepatitis C is transmitted, one cannot get hepatitis C from common contact such as kissing, hugging, coughing, sneezing, or by sharing food and water. But it is possible to get hepatitis C if you come into contact with the blood of someone who has hepatitis C. Contracting hepatitis C through blood transfusions and organ transplants used to be a common way someone could get infected before the early 90s, but now all donated blood and organs are screened for hepatitis C to prevent such a tragedy. Today, it is rare to get hepatitis C that way. Another rare way one can contact hepatitis C is by being born to a hepatitis C infected mother, or a health care
This research paper is going to review today’s silent killer, the Hepatitis C virus. This paper will talk about the description of the disease, the signs and symptoms, the etiology and risk factors, diagnostic studies, treatments and prognosis of this disease. I had lived with this disease for over ten years before diagnosed so it is important to understand the signs and symptoms so the disease can be identified and a treatment plan can be identified as the sooner it is treated the more likely it will eradicate the disease.
Liver cirrhosis, which is the end product of liver disease caused by HCV, is the leading cause of organ transplants in the United States (Hirsch, 2000).
A few years ago, Hepatitis C was a scary term for many of us. But, today the medical problem is curable as there are various and advanced ways available. The improvement in the treatment is especially notable because experts have worked harder to obtain this success. Still, there are some significant changes are left and hopefully they will be completed soon. Presently, the HCV treatments get rid of the virus in merely slightly more than half of all sufferers. The medicines also have unnecessary side effects that make it complicated or not possible for some patients to get them. HCV medication online available, but it is not worthy to take them without the concern of the doctor.
About 4.1 million people in Americans have the positive antibody to hepatitis C virus (HCV), and about 75 percent have permeant infection. Additionally, most of the infections happened 20 to 40 years ago, before the finding of HCV. Hepatitis C increased from 7,000 to 13,000 deaths in 2005. Furthermore, HCV develops slowly which increases the risk of severe complications in the infected people. Identification, death, and treatment are predicted to affect 35,000 by 2030. The Center for Disease Control (CDC) used antiviral therapy with PEGylated in clinical trials (Kalichman, Washington, Kegler, Grebler, Kalichman, Cherry, & Eaton, 2015). The CDC recommends a HCV one time test for people born between 1945 and 1965. The objective of this study was to thoroughly evaluate the amount of substance abusers infected with hepatitis C in the United States. Additionally, to observe the treatment of HCV. Currently Medicaid and Medicare repayment standards for sofosbuvir were calculated in all states, including the District of Columbia. Medicaid and Medicare covered the drug based on the following conditions; liver disease stage, HIV, and drug use. Approximately 42 states reimbursed the following criteria up to 74 percent for the drug sofobuvir. About two-thirds of the United States restricted the treatment centered on prescriber type. About 88 percent included drug abuse in their sofosbuvir admissibility measures. Finally, 50 percent required a date of abstinence and 64 percent required
Many people don’t understand how dangerous Hepatitis C is because it is not commonly known about as much as Hepatitis A or B. This disease is however very serious. Although frequently asymptomatic in time the virus can lead to cirrhosis, liver cancer and liver failure. Symptoms of HCV are jaundice (yellowing of the eyes), stomach pain, nausea and fatigue. Treatment options for the disease, if caught early enough is a combination of medications or depending on the degree of damage, a liver transplant. ”For some people, hepatitis C is a short-term illness but for 70%-85% of people who become infected with
14-Hepatitis C- is a slow-developing disease that can lead to liver damage and liver cancer as many as 30 years after infection. Remission can occur in up to 15 percent of people infected with HCV and four percent of infected people die from the virus.
About 4.1 million people in Americans have the positive antibody for hepatitis C virus (HCV), and about 75% of them are persistently infected and most of the infections happened d 20 to 40 years ago, before the finding of HCV. Hepatitis C increased from 7,000 to 13,000 deaths in 2005. Furthermore, HCV develops slowly which increases the risk for severe complications in the infected people. Identification, death, and treatment is predicted to affect 35,000 by 2030. The Center for Disease Control (CDC) used antiviral therapy with PEGylated in clinical trials. The CDC recommends a HVC one time test for people born between 1945 and 1965.They observed testing by birth. The objective of this study was to thoroughly evaluate the amount of substance abuser infected with hepatitis C in the United States. Additional to observe the treatment of HVC. Currently Medicaid and Medicare repayment standards for sofosbuvir were calculated in all states including the District of Columbia. Medicaid and Medicare covered the drug based on the following classes liver disease stage, HIV, and drug use. Approximately 42 states reimbursed the following criteria up to 74% for the drug sofobuvir. About two thirds of the United States restricted the treatment centered on prescriber type. About 88% included drug abuse in their sofosbuvir admissibility measures. Finally 50% required a dated of abstinence and 64% required drug test. The latest drug to HVC is called Sovaldi and it costs $84,000 for the 12
In time the virus can lead to cirrhosis, liver cancer and liver failure. Symptoms of HCV are jaundice (yellowing of the eyes), stomach pain, nausea and fatigue. The main problem is that many people don’t have symptoms until they already have some sort of liver damage. Treatment options for HCV include a combination of medications or depending on the degree of damage, a liver transplant. Given that HCV it is a blood disease that is spread through contact with an infected person’s blood, there are many ways to contract this disease. Injection drug users, physical altercations, sexual contact and mother to infant infection are just some of the ways this disease is spread.
Recall the dreaded trips to the doctor’s office when it was time to get shots. These shots are vaccines, which provide immunity to certain diseases. You received vaccines for Tetanus, Hepatitis B, Measles and Polio. A vaccine you did not get though, is one for Hepatitis C. Hepatitis C is a disease that affects the way the liver operates, and although there is a vaccine for both Hepatitis A and B, there is not one for C. Hepatitis C affects the digestive system, more specifically the liver. It can also damage the central nervous system and the circulatory system. Blood tests are the most common way to detect Hepatitis C and after one has been diagnosed with it, there are many ways to treat it. Hepatitis C is a treatable disease with varying
There are a number of individuals who may be suffering from an illness and not even be aware they have an illness. One example of such illness is Hepatitis C (HCV). Hepatitis C is a severe disease of the liver. It is caused by the Hepatitis C virus (Centers for Disease Control and Prevention (CDC), 2015). As a result, Hepatitis C has been termed a silent epidemic (CDC, 2015). This is because a lot of individuals have Hepatitis C and don’t even realize they have the infection (CDC, 2015). As the infection begins to progress over time, it could cause acute issues to the liver (CDC, 2015). Those issues could be things like damage to the liver, the liver could fail to function, cirrhosis, or even cancer of the liver (CDC, 2015). However, screening for Hepatitis C will allow an individual to benefit from treatments that are available, hence eliminating the disease from the body and preventing the liver from undergoing any further damage (CDC, 2015).
Hepatitis is an inflammation of the liver. Hepatitis is most commonly caused by viruses, and can cause your liver to become inflamed, swollen and tender. The symptoms of Hepatitis start out like the flu with coughing, fever, aches, and vomiting. However, the disease gradually worsens with symptoms of extreme weakness and excruciating abdominal pain. Never the less, Hepatitis can also be caused by alcohol and some other toxins and infections. There are many forms of Hepatitis; the most commonly seen forms are Hepatitis A, Hepatitis B, and Hepatitis c. Furthermore, Worldwide, 500 million people are estimated to be infected with Hepatitis B or C. These viruses kill 1.5 million people a year; 1 in every 3 people has been exposed to either or both viruses and most infected people do not know about it due to dormant symptoms.
In general, a patient is infected with only one hepatitis C virus genotype. The strain of genotypes is not differentiated by the severity of the disease. However, there will make a distinction in the regimen and the duration of the treatment (CDC, 2016). Treatment for chronic HCV is based on guidelines from the Infectious Diseases Society of America (IDSA) and the American Associations for the Study of Liver Diseases (AASLD). The criteria of who should receive the treatment include how much the virus in the body, the strain of hepatitis C, the degree of liver inflammation or damage, comorbidity, and response to previous treatment (Infectious Diseases Society of America [IDSA], 2016). The highest priority for treatment should give to a patient with advanced fibrosis and compensated cirrhosis (IDSA, 2016). Moreover, treatment priority should provide to the patient who has a high risk of transmitting the disease from and to others, such as individuals who are active injection drug users and hemodialysis patients (IDSA, 2016).
The expression genotype indicates diverse genetic variations or strains of Hepatitis C. The difference in genetic variations is approximately one third between the various genotypes. There are six main groups or genotypes numbered from 1 to 6. Each genotype is divided into subtypes (for example 1a and 1b) and mutations of the hepatitis C virus called quasispecies. HCV persistently mutates as it replicates. Each day more than trillion hepatitis C virions replicate. Throughout the replication process, HCV will make flaws or errors in the genetic make-up of the newly replicated viruses which will result in constant mutations. The process of persistent mutation aids the virus to escape the body’s immune response. When the major quasispecies is
Hepatitis is inflammation of the liver. There are currently five known viruses that cause can hepatitis (Microbiology, 10e). The hepatitis C virus (HCV) is transmitted through contact with the blood of an infected person; however, it is now more commonly spread among IV drug users that share needles. Healthcare workers are also at risk for contracting HCV, but with standard precautions, the risk is low. “Prior to 1992, some people acquired the HCV infection from transfusions of blood or blood products. Since 1992, all blood products have been screened for HCV, and cases of HCV due to blood transfusion now are extremely rare. HCV can be passed from mother to unborn child. Approximately 4 out of every 100 infants born to HCV-positive mothers
Hepatitis C is an inflammation of the liver’s cells and tissues caused by the hepatitis C virus (HCV).