The American Heart Association (AHA) updated the 2005 cardiopulmonary resuscitation clinical practice guidelines after the New England Journal of Medicine published two landmark studies in 2002. The HACA and the Bernard, et al. study found significant improvement in neurological outcomes with therapeutic hypothermia. Additionally, the Bernard, et al. study also revealed reduced mortality after cardiac-arrest survivors received therapeutic hypothermia (2002). In 2010, the AHA strengthened its position based on the growing body of research. Therapeutic hypothermia was the only intervention shown to improve neurological outcomes (Peberdy, et al., 2010). The most updated guidelines, set by the AHA in 2015, recommended that all comatose, …show more content…
The researchers determined that further investigation is still needed, especially in regards to length of cooling and rewarming rates. There were multiple limitations to this study. The patient in the 34°C group had poorer prognostic factors, fewer resuscitation attempts, longer time to ROSC, and worse Glasgow coma score (Lopez-de-Sa, et al., 2012). While data favored the 32°C group, one point of consideration is that, as a pilot study, their aim was not to change practice but offer a basis for future research (2012).
The second RCT, by Nielsen, et al. (2013), challenged the depth of TH needed for neurologic protection. The trial authors found no benefit of cooling unconscious OHCA patients to 33°C compared to cooling to 36°C at either hospital discharge or 180-day follow up. There was no harm established in cooling to 33°C, but none of the point estimates favored the 33°C group (Neilsen, et al., 2013). The TTM study was a landmark point in the TH literature. When it was published, the TTM study represented the largest study to date on the benefits of TH. It also provided insight into different TTM protocols. While the conclusions drawn were somewhat controversial at the time, the authors maintained that their study should not be interpreted to conclude that TH should be abandoned (Perchiazzi, et al., 2014).
Two observational studies were included in this synthesis. A Swedish observational retrospective cohort study, by
Initially, cooling was recommended to 32° C-34° C[6, 7], but the enhanced effect of cooling at 33° C compared to 36° C in terms of mortality and neurological outcome could not be proven[2]. Since the most optimal cooling level is yet unknown, current (2015) Resuscitation Guidelines recommend mild hypothermia treatment regimen at the temperature range between 32° C and 36° C[3, 4].
b. The prevention and management of unintended hypothermia remain a nation priority in preventing surgical site infection, and it has been designated as an SCIP quality measure. (Philips, 2015)
Original research related to sedation management occurred in the year 2000 by Kress, Pohlman, O ' Connor, and Hall. Their findings served as a landmark study and initiated the impetus related to improving our sedation practices. According to Kress et al. (2000), daily interruption of sedation led to a decrease in the number of days on the ventilator in the intensive care unit. Several studies since this time have focused on the influence of sedation protocols, and outcomes. This paper will review the synthesis of the discovered studies and highlight the noted contraindications and inconsistencies. Also, explanations including a preliminary conclusion will be discussed.
He then took samples of urine, blood, and mucous as body temperatures lowered. Through this tortured, Rascher used the data to create the hypothermia treatment called "active rapid rewarming." More than 90 people lost their lives for this medical advancement (Adams).
It is a beneficial treatment that should be implemented as early in patient care as possible, such as, within the EMS system. Through the last century this therapy has been accepted and rejected by many medical professionals. Since medicine is an ever-changing field, future research and practice of hypothermia will dictate if this therapy is more beneficial than harmful, and maybe one day could be a permanent major role, or it may never be used again. Hypothermia has been proved to decrease neurological impairment after cardiac arrest, but also has many limitations that can occur. A major limitation of this therapy is, if continued care cannot be guaranteed by receiving hospitals, therapeutic hypothermia is irrelevant for EMS to initiate. Likewise, if hypothermia is not begun in the field by EMS, then the receiving facilities now will have a delayed time in starting the therapy and anoxic brain injury could have already occurred. EMS agencies can drive the implementation of therapeutic hypothermia in the medical field. This therapy allows EMS providers to have a major role in the outcome of a cardiac arrest patient’s recovery and neurological outcome. With the progression of research and practice, medicine is evolving day after day, and patient mortality and morbidity have decreased over the years. Although, cardiac arrest patients have a poor
hypertension. Therapeutic hypothermia (THT) has been considered an effective method for reducing ischemic injury of the brain due to cardiac arrest. But there are some opponents in the medical community who believe that broadening the scope of THT could be dangerous to patients. Although opponents do not seem to blame THT for adverse patient outcomes; the disagreement seems to be about the variables involved before hospital arrival, amount of time that it takes to administer THT in the ER, which therapies should be administered with THT and the need for more research that tracks adverse events. A study published by The American Journal of Emergency Medicine supports the widely held view that THT is an effective treatment for cardiac arrest
Markus Thalmann, the cardiac surgeon who saved the little girl from death by drowning in icy water, said that she was not the first hypothermia and suffocation case. However, she was the first one to survive. In her complicated rescue they tried to follow a checklist that stats that in such a case, a rescue team was required to tell the hospital to prepare for possible cardiac bypass and rewarming. So, what was so effective about this approach is that by the time the patient gets to the hospital, everything is ready and standing by. These kinds of cases are time sensitive. In such complicated cases, success requires having a huge number of equipment and people at the ready. So, even small simple checklist could help in complicated rescues and even bring people to life
These procedures are not reported alone but as add-on codes used to identify extraordinary conditions of patients and their unusual risk factors. There are four kinds of certain codes used for particular circumstances which are: 1) Anesthesia for the age younger than one year and over the age of seventy (99100), 2) Anesthesia complicated by the utilization of total body hypothermia (99116), 3) Anesthesia complicated by the utilization of controlled hypotension (99135) and 4)Anesthesia complicated by emergency circumstances
A Glasgow Coma Score of 8 or less also is an indication that the patient will need to be intubated soon. Once the tube is placed the ventilation may be useful in controlling the intracranial pressure as an intervention. Hyperventilation is a method used to reduce the carbon dioxide concentration in the vessels causing vasoconstriction which lessens the amount of blood circulating in the brain resulting in a decreased ICP (Zink and McQuillan, 2005). According to Zink and McQuillan, this intervention should only be utilized 24 hours after the initial injury because cerebral blood flow is often reduced at this point and constricting the vessels more may cause ischemia to occur. While using this technique it is important to monitor oxygenation to the brain tissue to assure no irreparable damage is
The American Heart Association (2011) states that, "Therapeutic hypothermia is the only intervention demonstrated to improve neurologic recovery after cardiac arrest" (Pp 77). Recommendations range between 32 and 36 degrees centigrade for 12 to 36 hours. Cooling may be achieved through either introduction of cooled, isotonic, non-glucose-containing fluid, or surface cooling interventions like ice packs or cold packs. The AHA states, however, that patient core temperature must be monitored by an esophageal thermometer, a pulmonary artery catheter, or a bladder catheter and that peripheral temperature measurements via axillary, aural, or oral thermometers are inadequate for measuring core temperatures in targeted temperature management. Therefore, while the AHA does recommend initiation of therapeutic hypothermia by EMS personnel in certain situations, agencies must carry--and be trained in the use of--equipment to adequately measure the patient 's core temperature. Further, the AHA states that therapeutic hypothermia results in increased neurologic function post-cardiac-arrest but does not identify a timeframe for initiation for these protocols, let alone explore whether or not initiation of post-cardiac-arrest targeted temperature management by EMS influences patient outcomes.
Therapeutic hypothermia, also called targeted temperature management, is a procedure that lowers the body's temperature in order to treat a heart that has suddenly stopped working (cardiac arrest). This procedure is used in emergency situations. During cardiac arrest, the brain cannot get enough oxygen. The brain also starts to swell, which can damage or kill brain cells. Therapeutic hypothermia helps reduce swelling in the brain. It also slows down the body's metabolism and allows the heart and brain to recover.
Malignant hypothermia is a disease, caused by a bad reaction of anesthetics. This disease causes an immensely rapid temperature rise and extreme muscle contractions. MH (malignant hypothermia) is passed down through families and inherited by one parent carrying it giving it to the child. “Malignant hyperthermia occurs in 1 in 5,000 to 50,000 instances in which people are given anesthetic gases” (NIH, 2007). Most people aren’t aware that they are prone to this disease/reaction because they have never been under anesthesia drugs, or have never received surgery.
This article is a example of a foundation of knowledge on the topic of therapeutic hypothermia. Gardner & MacDonald discuss that the typical post cardiac arrest patient does not survive or will recover with severe neurologic deficits as a result of ischemic brain injury from lack of blood flow to the brain (2013). The process of brain death is examined as well as the damange that occurs with reperfusion after ROSC. Damage particularly to the cerebral cortex, cerebellum and hypothalamus can leave the patient in a comatose state if revived (Gardner & MacDonald, 2013). This article is particuarlly valuable as it explains on a physiological level how TH protects the brain from reperfusion injury and improves neurologic outcomes and survivability. The article defends that TH is the best practice for preventing further neurologic damage after ROSC and provides a clinical example. The clinical example recounts a case in which a patient suffered an out of hospital cardiac arrest. Upon admission to the ICU the therapeutic hypothermia protocol was initiated and the patient was cooled below 35 degrees celcius for 24 hours. After rewarming the patient regained consciousness and within ten days was discharged from the hospital with normal neurologic function and as a survivor (Gardner & MacDonald,
As evidenced, normothermic perfusion preservation is making a positive impact on the medical community. There are many benefits to the normothermic perfusion technique that is causing its rapid ascent, including: a unique opportunity to recover from established or acquired injury during transplant, an ease of measuring organ function prior to implantation, and a remarkably improved rate of both patient and liver survival post-operative.
The safety and benefits of hypertonic saline resuscitation extend to both the pediatric and geriatric populations, but using solutions at the lower end of tonicity is probably safer. The greatest benefit may ultimately be for those patients with the most limited cardiopulmonary reserves, those with inhalation injury, and those with larger burns approaching 40% or