IPF Compliance Report

488 Words2 Pages
Predicting clinical course of IPF is extremely difficult and despite the progress in the field reviewed in this article, survival prediction in the single IPF patient remains an unmet clinical need. This task is limited by multiple factors. On one hand diagnostic delays related to different patients symptoms perception and healthcare operators awareness, but also different biological disease characteristics might cause a high variability of disease presentation at time of diagnosis. Furthermore, largely unknown triggers might dramatically affect disease course, with patients who originally displayed a stable disease progressing to rapid decline in lung function. In this respect, recent data suggest that even medical interventions considered standard therapy until few years ago might have contribute to disease progression in a significant fraction of IPF patients83. On the other hand, the complex pathophysiology of IPF, that is characterized by a combination of gas exchange, ventilatory and cardiovascular response abnormalities, limits the correlation between single traditional clinical…show more content…
These scoring systems have the advantage to take into account different aspects of the disease at the same time increasing the amount of information on the status of the single patient. However, to date none of the proposed systems can be considered extent of limitations. In fact, some of the published studies are limited by their retrospective nature or by the relative small numbers of analyzed prospective cohorts. Availability of prospective data from the large database of recent clinical trials has partially overcame these limitations. However, this studies have generally enrolled mild or moderate patients that might not represents the "real life" clinical setting missing advanced and rapidly progressing disease forms and therefore might underestimate the real disease burden of
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