The National Center for Toxicological Research recommends Igor Pogribny, M.D., Ph.D., Research Biologist of the Division of Biochemical Toxicology, for appointment in the Senior Biomedical Research Service (SBRS) under Biomedical Research category. Dr. Pogribny’s career began in the former Soviet Union, where he received his basic education, followed by M.D. and Ph.D. degrees. His major area of interest was the study of biochemical and molecular mechanisms that led to cancer cell transformation. Since 1992, Dr. Pogribny has continued his research in the United States, and has focused on the biochemical and molecular mechanisms of carcinogenesis. During 30-year research career, Dr. Pogribny has continued to publish the results of his research in peer-reviewed journals and to present his work at national and international scientific meetings. His productivity is demonstrated by a total of 329 publications and presentations. He is the corresponding author of 35 of the manuscripts. His articles have been cited more than 10,500 times with the h-index of 58 according to the Google Scholar website. Dr. Pogribny serves as the principal investigator and co-principal investigator on several approved NCTR …show more content…
Therefore, evaluating the hazard risk of chemical agents continues to remain important. Recognition of the fundamental role of epigenetic mechanisms in the development of major exposure-related human diseases suggests that epigenetic alterations may represent a class of biomarkers with great potential in the identification of exposure status, damage response, and/or disease state and be an essential tool for hazard identification, particularly for non-genotoxic and non-receptor-mediated agents regulated by the
Ivan IV was a complicated man, with a complicated past, in a complicated country, in a complicated time; his story is not an easy one. Ivan the terrible, the man, could never be completely understood in a few words, nor in a few pages, and only perhaps in a few volumes. A man of incredible range his dreadfulness could only be matched by his magnificence, his love by his hatred.
What has been brought to light in recent years is the effects of these chemicals on the body’s immune response. By introducing these toxic chemicals into the body, the potency of the immune system is compromised. More commonly than not, the body’s magnificent defense system will kick in and destroy foreign invaders but all it can take is an overwhelming amount of chemicals to slow or even shut down the body’s response systems. A large amount of these types of chemicals introduced into the body at one time would be considered acute toxicity and could even cause death. Additionally, a small amount of these poisonous substances brought into the body over a long period would be considered chronic toxicity and can have detrimental effects on the body’s natural response (Hoernschemeyer 55-57). This information is startling enough to want to make a change from conventionally grown food to pesticide-free organic
Vladek went through the various Nazi genocide stages as brought out by Raul Hilberg. According to Hilberg, the four distinct phases of the Holocaust were identification, economic discrimination, and separation, concentration, and extermination. Although Vladek was not eventually exterminated, his close relatives and friends did not survive the lethal last stage through the various sugar-coated tactics employed by the Germans. The essay will scrutinize these Holocaust stages and relate them to the life events of the Vladek, the main character in Maus 1 and 2 written by Art Spiegelman. The works of other scholars in predicting the impacts of the Holocaust will also be looked at.
The book I chose to do my book report on is "One Day in the Life of Ivan Denisovich". The book is about the most forceful indictments of political oppression in the Stalin era Soviet Union. It is a captiving story about the life in a Siberian labor camp, related to the point of view of Ivan Denisovich, a prisoner. It takes place in a span of one day, "from dawn till dusk" (pg. 111) . This book also describes his struggles and emotional stress that he must going through.
In the poem "Feliks Skrzynecki", Skrzynecki explores how events shape the identity of an individual by highlighting rifts in the poet’s and his father's relationship and identifying how they affected the poet’s identity.
I’m doing my report on Ivan the Terrible. Ivan Vasiljevich the Terrible was born in 1530 and died in 1584. He was the son of the Grand Duke Vasili III. His mother Helena Glinsky was the daughter of a Luthuanian refugee who had found asylum in Russia. She was young, vivacious, intelligent, and beautiful. Vasili had married her after he tried to have an heir for 20 years with his first wife Salome.
Looking back in time at the great composers of the world, only one foreign composer stands out for his many contributions to classical music and in helping America to find its own music. Antonin Leopold Dvorak was born on September 8th, 1841, in a small village of Nelahozeves in Bohemia that lies on the bank of the Mauldau River. The village Dvorak was born into was in good company and surroundings however also retained much of its native luster even through the worst times of political oppression (1).
once this was a very silly idea as they would not be able to pull it
In The Death of Ivan Ilych Leo Tolstoy conveys the psychological importance of the last, pivotal scene through the use of diction, symbolism, irony. As Ivan Ilych suffers through his last moments on earth, Tolstoy narrates this man's struggle to evolve and to ultimately realize his life was not perfect. Using symbols Tolstoy creates a vivid image pertaining to a topic few people can even start to comprehend- the reexamination of one's life while on the brink of death. In using symbols and irony Tolstoy vividly conveys the manner in which Ilych views death as darkness unto his last moments of life when he finally admits imperfection.
The Gulags of the Soviet Union have been compared to the concentration camps of Nazi Germany, but in reality they were worse. The Gulags were isolated prison camps peppered across Siberia. Death, torture, and disease raged within their walls, while endless work went on outside. Gulag personnel were cruel and unfeeling, using terrible punishment methods and playing senseless games that cost prisoners their lives. Political enemies of the Bolshevik party made up a significant portion of the prisoner population, with most sent to the infamous camp system Kolyma. Liberation was painfully slow, but by 1960, all of the Gulags were gone.
The One and Only Ivan by Katherine Applegate is about Ivan, a silverback gorilla who is raised by a human and lives in captivity at the Exit 8 Big Top Mall and Video Arcade. Ivan is brought to the Exit 8 after being captured and separated from his family while living in the wild. Ivan considers his new habitat a “domain” and refuses to admit that he is living in a cage. However, when Stella, an elephant, dies as a result of neglect, Ivan is forced to accept his situation. Moreover, he has to fight to keep the promise he made to save Ruby, a young elephant, from going down the same path as the rest of them. In her novel, The One and Only Ivan, Applegate uses characterization, setting, and plot to convey Ivan’s determination to become a protector.
ATchaikovsky=s music is not only one of the cornerstones of Russian musical society and world music . . . It is at the same time a creative and technical encyclopedia to which every Russian composer has reference in the course of his own work,@ commented Dimitri Shostakovich.1 This was a typical view held by Tchaikovsky=s contemporaries. He was well known and well respected, especially in his later years. In addition, Tchaikovsky was recognized as the most expressive Romantic composer in Russia.2 He was often idolized and put on a pedestal, particularly during his tour of the United States in 1891 when he conducted concerts of his own works in some of the leading concert halls. Tchaikovsky brought national attention to
Epigenetics can be hereditable or environmental factors that affect the expression of genes and lead to changes in gene expression. Unlike genetics, epigenetics does not only have to do with which genes are passed down to the offspring and the DNA sequence. The environmental conditions of the offspring’s parents impact the genes in their eggs and sperms by “switching on” certain genes and “switching of” others (Dowshen). Since the genes expression of the gametes are affect, the phenotypes of the offspring will change. Even in a person’s lifetime, environmental factors such as stress, chemical exposure, and diet can continue to impact gene expression through DNA methylation. During DNA methylation, a methyl group is randomly added to a 5-carbon cytosine ring, making 5-methylcytosine and these groups inhibit transcription. (Cheriyedath). Due the fact that transcription is not possible, the expressing of the genes in that section of the DNA strand will be suppressed. The attachment of the methyl group to DNA is not determined, which means that
One country is comparable to the United States of America in terms of world power and prominence. Russia makes their name known beginning in World War 2 (WW2), later in the Korean War, Cold War, and today’s proxy war in the Syria. Russia’s culture, environment, politics, military, and economy do not just make Russia a regional powerhouse, but slowly becoming a region of influential power to surrounding countries with the end state of a global superpower. All the factors that make Russia the powerhouse that it is slowly becoming, highlights the impressive trend that supersedes the previous Soviet Union and past leaders.
When we hear the term Russian culture many Americans tend to have negative thoughts like the cold war, their government ruling with an iron hand, and the Red Scare. These thoughts do not do the justice to the Russian people or to their long history as a people dating back to INSERT DATE. One of the major themes throughout Russian history and this course is the idea that the Russian people value intangible things more than the tangible. The Russian people have a long rich heritage, they are deep in there Christian faith, and they pride themselves on hospitality and value there community, families, and fellow Russian people. They have learned how to sacrifice from the constant invasions and being forced farther and