Key Elements For Tissue And Organ Regeneration

1830 Words8 Pages
Introduction Tissue engineering is an interdisciplinary approach that basically replaces, restore the function and regenerate the damaged cell or tissue using biological substitutes. Succinctly, extracellular matrix (ECM) in human tissue is a key element for tissue and organ regeneration. It provides a convenient environment for the cellular attachment, growth and migration stimulate by specific signals. This solid matrix has a complex mixture of structural and functional proteins that serve as a reliable source of nutrient for the cells. ECM also associated with the cell behaviour, tissue differentiation, organisation and neovascularisation. In tissue engineering, the suitable scaffolds are use to act as an ECM analogue (1). The various roles and complicated composition of ECM become a great challenge for the scaffolds to mimic the native ECM in repairing the diseased or damaged tissue. Thus, it is important to develop the ideal scaffolds with optimal properties and architecture since its mechanical characteristics will greatly affect the activity of cell adhesion, proliferation and differentiation. Apparently, the biomaterial used in fabrication of scaffolds may influence its significant features, such as biodegradability, bioactivity and porosity. The bioactivity, including cell adhesion, cell alignment and interaction between scaffolds and cellular components could be enhanced by adding the biological cues onto the biomaterials. Besides that, it is also important for
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