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M13 Virus

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Viruses are usually known for sickness, or wreak havoc on your computer. Yet, scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have developed a way to generate power using harmless viruses that convert mechanical energy into electricity. Seung-Wuk Lee, a faculty scientist in Berkeley Lab’s Physical Biosciences Division and a UC Berkeley associate professor of bioengineering conducted the research with a team that includes Ramamoorthy Ramesh, a scientist in Berkeley Lab’s Materials Sciences Division and a professor of materials sciences, engineering, and physics at UC Berkeley; and Byung Yang Lee of Berkeley Lab’s Physical Biosciences Division. The scientists are exploiting a principle …show more content…

The M13 bacteriophage only attacks bacteria and is benign to people. Being a virus, it replicates itself by the millions within hours, so there’s always a steady supply. It’s easy to genetically engineer. And large numbers of the rod-shaped viruses naturally orient themselves into well-ordered films. These are the traits that scientists look for in a nano building block. But the Berkeley Lab researchers first had to determine if the M13 virus is piezoelectric. Lee turned to Ramesh, an expert in studying the electrical properties of thin films at the nanoscale. They applied an electrical field to a film of M13 viruses and watched what happened using a special microscope. Helical proteins that coat the viruses twisted and turned in response—a sure sign of the piezoelectric effect at work. Next, the scientists increased the virus’s piezoelectric strength. They used genetic engineering to add four negatively charged amino acid residues, biologically important organic compounds containing amine (-NH2) and carboxyl, to one end of the helical proteins that coat the virus. A helical proteins, or alpha helix, is a common biological molecule in the secondary structure of proteins and is a right hand-coiled or spiral conformation in which every backbone N-H, or amine, group donates a hydrogen bond to the backbone C=O group, or carbonyl group, of the amino acid located three or four residues earlier along the protein, sequence. The scientists further enhanced the system by stacking films composed of single layers of the virus on top of each other. They found that a stack about 20 layers thick exhibited the strongest piezoelectric

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