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Major Depressive Disorder Essay

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• 1 •Chin J Integr Med Depressive symptoms do not represent a mood disorder, but rather an organic dysfunction.(1) Depressive symptoms and cognitive decline are common in schizophrenia, major depressive disorder (MDD), bipolar disorder, and Alzheimer's disease (AD).(2) Moreover, depressive symptoms have been associated with increased risk of cognitive decline.(1) The relationship between depressive symptoms and cognitive decline is complex. Recently, cross-sectional studies have demonstrated a strong association between progression of depressive symptoms and white-matter changes, particularly in frontal pathology.(3) Neuroimaging and postmortem studies have also linked the depressive and cognitive symptoms of these disorders…show more content…
Two concentrations of induced demyelination was used to mimic demyelinating disease. Two concentrations of A. . catechucatechu nut extract nut extract (ANE; 1% and 2%) were administered orally in the diet for 8 weeks. Depressive symptoms and cognition-associated (ANE; 1% and 2%) were administered orally in the diet for 8 weeks. Depressive symptoms and cognition-associated behaviors were evaluated in tests of locomotor activity, tail suspension, and forced swimming; spatial memory was behaviors were evaluated in tests of locomotor activity, tail suspension, and forced swimming; spatial memory was tested with the Y-maze. Expression of myelin basic protein (MBP), 2',3'-cyclic-nucleotide 3'-phosphodiesterase tested with the Y-maze. Expression of myelin basic protein (MBP), 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNPase), glutathione S-transferases pi (GSTpi), brain-derived neurotrophic factor (BDNF), and the transcription (CNPase), glutathione S-transferases pi (GSTpi), brain-derived neurotrophic factor (BDNF), and the transcription factor cyclic adenosine monophosphate (cAMP) response element-binding (CREB) were evaluated by western blot. factor cyclic adenosine monophosphate (cAMP) response element-binding (CREB) were evaluated by western blot. ResultsResults: Animals subjected to demyelination showed hyperactivity (: Animals subjected to demyelination showed hyperactivity (P<0.01), impaired spatial memory (<0.01), impaired spatial memory (P<0.01),
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