Myostatin Genetic Essay

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The myostatin gene, also known as the differentiation factor 8 gene is a gene that when repressed causes a mutation of increased muscle mass displaying a double muscling phenotype (Bellinge). The myostatin gene mutation phenotype first became prevalent in cattle which showed an increase in the number of muscle fibers and the size of the fibers (Bellinge). The normal function of the gene when expressed is to give rise to developing or mature muscles (Bellinge), and to regulate the amount of muscle fibers that are produced in the body (Lee, 2004). Generation and differentiation of myoblasts, undifferentiated cells capable of becoming muscle cells, are regulated by myostatin to control the amount of muscle fibers that are made (Lee, 2004). One of the ways that the myostatin gene regulates the amount of muscle fibers produced is through the cell cycle. Myoblasts build up in the G0, G1 and G2 phase of the cell cycle …show more content…

Satellite cells are cells that can develop into skeletal muscle cells and have been shown to re-enter the cell cycle from G0 to initiate growth of muscle fibers (Lee, 2004). In comparing wild type mice to mutant mice for the myostatin gene it has been shown that there are a larger number of satellite cells in mice that mutant (Lee, 2004). This demonstrates that when the satellite cells leave G0 phase and enter the cell cycle, myoblast begin to develop into muscle fiber cells increasing the muscle mass (Lee, 2004). The growth of satellite cells is beneficial to the body for growth and repair of the muscle cells (Lee, 2004) but not necessary otherwise. In order to ensure normal function of the myostatin gene it is essential to have the cell cycle regulating the myoblasts to stay in a state of quiescent, the G0 phase (Lee, 2004) so they are not being expressed or

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