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Opioids Case Study Essay

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I. Opioids Study 1: Jae-Hwang Song et al. divided 336 patients undergoing foot and ankle surgery under sciatic or femoral-sciatic nerve block into treatment and control groups Based on the date of surgery. All the patients received a nerve block preoperatively. The block was established with mixture of lidocaine and ropivacaine injection. In the postanesthesia recovery room, a transdermal patch of fentanyl was applied to the chest of the patients with intravenous midazolam in the treatment group. The primary outcome measure was the difference in the number of requests for additional postoperative pain medication. The secondary outcome of interest was the degree of postoperative pain using a visual analog scale (VAS). also, complications noticed. Metoclopramide was given to nauseated patients (6). Results: 47.12% in the control group patients and 27.16% in the …show more content…

Group N showing a faster onset compared to group B and the time that was taken to achieve complete block was shorter in group N. also, group N had prolonged postoperative analgesia (11). Discussion: The onset of sensory and motor block was faster and time taken to attain complete sensory and motor block to occur was shorter in the nalbuphine group as compared to bupivacaine group. Postoperative regression of both sensory and motor block was significantly slower in group N than in group B and the first rescue analgesic requirement in group N was significantly late than in group B. 0.8mg intrathecal nalbuphine as an adjunct to spinal bupivacaine prolongs the postoperative analgesia with minimal side effects and with desirable sedation intraoperatively which helps in taking care of psychological impact of operation theatre environment. Rawal et al found that nalbuphine was the least irritating to neural tissue even when used in large doses and was associated with minor behavioral and EEG changes

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