Pulmonary Fibrosis is a condition where the lung tissue becomes thick and scarred, but it is more serious than just thinking you have scarring on your lungs. The thickening and scarring of the lungs makes it hard for the oxygen supply to be delivered throughout the body. This disease can develop slowly or quickly and can stay the same for years. Pulmonary fibrosis occurs in a variety of clinical settings, is a major cause of mortality, and represents an enormous medical need. However, the disease is heterogeneous and the failure to distinguish different types of fibrosing lung diseases can lead to inaccurate treatments. Pulmonary fibrosis occurs in the context of connective tissue diseases that are often characterized by a distinct pattern …show more content…
Little is actually known about how the disease develops. IPF is the most common and most severe form of idiopathic interstitial pneumonia. It is often relentlessly progressive, leading to death from respiratory failure within 2–5 years of diagnosis. Even though the overall prognosis is poor in IPF, it is difficult to predict the rate of progression. Over the last decade, a clinical trial in IPF coupled with the increased utilization of chest scans has led to the identification of patients at earlier stages of the disease process. However, predicting the clinical course in these patients is particularly challenging. The annual percentage of IPF appears to be rising and is estimated at 5–16 per 100,000 individuals. The most common symptom of pulmonary fibrosis is shortness of breath. Some of the mild symptoms are chronic dry hacking cough, fatigue, unexplained weight loss, aching muscles and joints, tiredness, discomfort in chest, and loss of appetite. Due to low oxygen levels, people with pulmonary fibrosis may have clubbing. Clubbing is when the flesh under your fingernails start to thicken causing the finger nail to curve downward. Pulmonary fibrosis isn’t just one disease. It’s like a big umbrella with over two hundred other lungs diseases that are alike. The umbrella of diseases falls into an even larger group of interstitial lung disease. There are many different types of ways you could get pulmonary fibrosis. Some of the causes are autoimmune
While the buildup of mucus on the lungs doesn’t allow the person to breathe as well, the buildup of mucus in the pancreas doesn’t allow the release of digestive enzymes that help the body break down food and absorb nutrients. There are many symptoms that come along with Cystic Fibrosis. The main symptom of Cystic Fibrosis is wheezing and shortness of breaths along with always having some type of lung infection
Pulmonary Fibrosis is a serious disease that claims and terrorizes thousands of lives and families. Due to severity of the disease two Senators have decided to introduce an Act that is dedicated to this horrifying disease (the Pulmonary Fibrosis Research Enhancement Act (PFREA)). After the onset of symptoms of pulmonary fibrosis, a person has about 5 years of lifespan, that’s taking in consideration treatment that will be given to the patient. About 30 present of patient that receive treatment for pulmonary fibrosis with oral glucocorticoids will see improvement in their lung function. There are many studies that are being to find a cure for the disease or find a way to present it, unfortunately the studies are still on going
The signs and symptoms of Cystic Fibrosis are going to involve the respiratory, gastrointestinal, reproductive and occasionally sweat glands. Usually we will see symptoms as early as birth as well as later in life. The very firsts signs of CF are noticed by parents on a new born child, when the child does not pass his stool(meconium) as well as a salty sweat in the forehead when kissed. (Health, 2013) Some relative sign and symptoms of the respiratory system include: cough, thick sputum, lung infections and sinus infections. The digestive system symptoms are a result of mucus blocking ducts and tubes. Constipation, stomach pain, Diarrhea, foul-smelling, greasy stools and poor weight gain are some of the main sings of CF. In the reproductive system females will have a hard time conceiving due to mucus in the cervix whereas males are considered infertile because they are born without a vas deferens tube. Other common signs and symptoms mostly seen with patient who have CF are salty sweat, fatigue, weakness, increased heart rate and decreased blood pressure.
At first there may be no symptoms or mild flu and cold, which are not necessarily, associated with COPD. But as your condition gets worst, there will be cough producing heavy mucus, (smoker’s cough), shortness of breath which may hinder you from physical activities, wheezing (a whistling or noisy sound when you breathe), and chest tightness.
Cystic Fibrosis, a genetic disease that is often considered progressive, affects a person's ability to breathe by causing frequent lung infections. A thick buildup of mucus in several organs such as the lungs and pancreas are caused by a defective gene in those with cystic fibrosis. This gene is inherited by either parent who carried the gene. In some cases, the buildup of mucus can cause respiratory failure or prevent the release of digestive enzymes that allows the body to break down food and absorb vital nutrients. Common symptoms to look for in people with cystic fibrosis are chronic coughing, frequent sinus infections, shortness of breath, salty tasting skin etc.
Cystic fibrosis is a genetic disorder that affects the lungs and digestive system. In order to inherit it, a child must receive a copy of the defective gene that causes it from both parents. A life-threatening condition, cystic fibrosis leads to the development of a thick mucus buildup in the lungs and other organs. This can cause recurrent infections and damage to the lungs, which can trigger respiratory failure. When the disease affects the pancreas, it interferes with the release of digestive enzymes needed to break down and absorb food. Mucus buildup in the liver can cause liver disease when the bile duct becomes blocked.
Smoking and secondhand smoke, fumes and chemicals, and genetic factors may be primary causes for COPD, but illnesses like bronchitis and emphysema are also key factors of the disease. These two illnesses are just other words some people use to describe COPD. According to Garell, chronic bronchitis and emphysema are known as COPD (67). Another fact stated is that “heredity is known to play some role in the department of this” (Garell 67). COPD is rarely caused by genetics, but should still be looked for. The
Pulmonary fibrosis is a lung disease that occurs when the tissue deep in your lungs become thick and stiff. Over time, the damaged tissue forms scar tissue. The term for the scar tissue is fibrosis. When the scarred tissue becomes too thick, breathing becomes difficult and symptoms arise.
Idiopathic pulmonary fibrosis is a horrible and ultimately fatal chronic lung disease in men and women. Characterized by irreversible loss of lung function, patients that are diagnosed are usually only given about 4 years to live. Although the cause of Idiopathic pulmonary fibrosis is still unknown, there are several risk factors involved. The symptoms of idiopathic pulmonary fibrosis are not specific, and are similar to many other types of pulmonary cardiac diseases. The majority of people with the disease have about a 6-month or more history of shortness of breath and/or nonproductive cough. About 5% of people with idiopathic pulmonary fibrosis do not have symptoms, and the disease is diagnosed when he or she is being examined for other medical
Chronic bronchitis’ occurs in a period of more than three months that continues in a period of two years (Copstead & Banasik, 2013, p. 483). The destruction of bronchial walls will result in dilation of airway sacs. The dilated sacs contain infected secretion from streptococcal and staphylococcal pneumonia, which can spread to nearby areas of the lungs such as other areas of the body and even to the brain.
COPD is a progressive disease that makes it difficult to breath. Loss of elasticity, the destruction of the air sacs (emphysema), airways becomes thick and inflamed (chronic bronchitis), and/or increased mucus thickness that blocks the airways. Smoking is the most common cause of COPD, however it can be caused by a long exposure to irritants to the lung, such as chemicals. COPD can be directly related to four different causes. COPD does not have a cure, it can only be managed.
Idiopathic Pulmonary Fibrosis is a type of disease that can happen differently in each person. The medical definition of Idiopathic Pulmonary Fibrosis is a disease marked by scarring in the lungs which can be very chronic. However, statistics state that this disease affects just about 128,000 people in the United States. Also, there are 48,000 new cases diagnosed and 40,000 that die each year because of Idiopathic Pulmonary Fibrosis (Facts About Idiopathic Pulmonary Fibrosis, 2015). Sometimes the disease can happen quickly or slowly in each person or it can stay the
Idiopathic pulmonary fibrosis (IPF) is a fatal irreversible disease that severely diminishes lung function. IPF is part of a 200 + lung disease group known as interstitial lung diseases (ILD). The ILD group of diseases adversely affects the interstitium, which is the interstitial space between the lung tissue and air sacs. IPF is characterized by the scarring and honeycombing of the lung tissue and the accretion of fibrosis. The word 'idiopathic' is derived from the Greek word ‘idios’, which means 'of unknown cause' and aptly explain the status of the prognosis of this deadly disease. Some of the symptoms of IPF is shortness of breath (dyspnea), crackling sound in the lungs, finger clubbing and unrelenting dry cough.
It is debatable as to whether advanced fibrosis can be reversed to the extent that normal tissue architecture is reconditioned completely. Indeed, there is important evidence to propose that, if fibrosis is markedly advanced, reversal is no longer possible. Indeed, fibrotic deposition related to recent disease and branded by the presence of thin reticulin fibers, often in the existence of a diffuse inflammatory infiltrate, is probably fully reversible, whereas long-standing fibrosis, characterized by extensive collagen crosslinking by tissue transglutaminase, presence of elastin, dense acellular/paucicellular ECM and decreased expression and/or activity of specific MMPs, is not reversible. Since advanced fibrosis is often hypocellular, it has been proposed that incomplete ECM degradation (irreversible fibrosis) develops when the appropriate cellular mediators (the source of MMPs) are no longer present (Issa et al., 2004).
When a non-smoker gets pulmonary fibrosis, it’s generally considered idiopathic pulmonary fibrosis, a form with no known cause. Pulmonary fibrosis is a progressive disease that varies in the rate of degeneration from person to person. Scarring of the lungs is irreversible.