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Research Paper On Propionibacterium Acne Vulgaris

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Propionibacterium species are gram-positive anaerobic bacilli. These species are part of the normal flora of human skin and mucosal surfaces such as oral cavity, gastrointestinal and genitourinary tracts and they usually not pathogenic (1) (2) (3). However, Propionibacterium acnes plays a major role in the development of acne. It could be the most common cause of inflammatory skin conditions acne vulgaris which is most common dermatological disorders seen by dermatologists (4) (5). Acne vulgaris is a disease in which affects the pilosebaceous units of the skin and can result in inflammatory or non-inflammatory lesions (6). It affects all ages but it is mostly associated with puberty with incidence peaking at 18 years of age …show more content…

It can be treated topically or systemically. Other treatment options include the use of natural drugs (6). Antibiotics are frequently used to treat acne patients. Long course regimens of antibiotics can be prescribed to treat acne, which can reach 6-9 months. Most antibiotics prescribed for acne treatment are: clindamycin, macrolides (e.g. erythromycin) and tetracyclines (5). However, increasing resistance have made acne treatment challenging. The incidence of P. acnes antibiotic resistance increased from 20% in 1978 to 72.5% in 1995 (8). Widespread resistance has become a major dermatological issue (9) common prescribing antibiotics in dermatology clinics can be the major cause of the antibiotic resistance due to significant selection pressure on bacteria (10). Some studies has showed a relationship between antibiotic use and the development of resistance to P. acnes in patients treated in general practice. In addition to that , it has showed cross resistance between macrolides/lincosamides and tetracyclines. Other study has suggested that the rate of resistance increases as the duration of antibiotic consumption increases (12). So, our study aims to o identify the cause of the decreased susceptibility of propinobacterium acne to the commonly prescribed antibiotics and to evaluate the current use of antibiotics in treating

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