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Summary Of The Worm Crop-Gizzard

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The worm crop-gizzard allows for pharmacological testing of multiple drugs in an in vitro preparation, which exhibits rhythmic contractions after it has been isolated from the worm. Serotonin (5-HT) decreases the amplitude of contractions while acetylcholine (ACh) increases them. We hypothesize that if serotonin directly effects muscle cells, then if acetylcholine and serotonin are added to the preparation at the same time, then the amplitude of the recorded contractions will decrease. The crop-gizzard was submerged in a saline solution and was pinned to a force transducer which recorded the intensity of the contractions. The average amplitude of contraction was compared to a baseline for three different trials in which exogenous (1) ACh, (2)

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