Synaptic Of Alzheimer 's Disease Essay

Alzheimer 's disease (AD) was discovered by a German doctor Alois Alzheimer in 1906 when he found amyloid plaques and neurofibrillary tangles in the autopsy of a woman who died of an unknown mental disease. The extracellular amyloid plaque deposits, composed of insoluble amyloid-Beta peptide were hypothesized to be the main etiological factor. “The most important abnormality is an excess of Amyloid-beta peptides brought about through either overproduction or failure in degradation.” (Uzun, Kozumplik, & Folnegović-Smalc, 2011) Later, it was discovered that intracellular neurofibrillary tangles composed of hyper-phosphorylated, helically-paired tau

It occasionally happens to everyone.  You can’t find your glasses.  The grocery list is on the refrigerator, and you’re at the store.  You forget the new neighbour’s first name.

In chapter 15 I found the part on Alzheimer’s disease very informative and interesting. Alzheimer’s and dementia are diseases that I find great interest in. My paternal grandfather was diagnosed with Parkinson’s disease when he was just over the age of 60. He proceeded to be diagnosed with Parkinson’s induced dementia, and then he later passed away from the disease. My maternal grandfather suffered from a severe stroke about 4 years ago, and is now suffering from stroke induced dementia. Seeing anyone who is suffering from Alzheimer’s and dementia of some sort is very sad. I work in an assisted living facility and we have a specialized facility of people who are diagnosed with Alzheimer’s or dementia. Working with these people on a daily basis

In this Chapter, we discussed the six pillars of Alzheimer’s prevention. Throughout the week, the great leader has built these “pillars” to help us understand and comprehend the greatness of preventing Alzheimer’s in the distant future.

Parkinson’s disease is a “neurodegenerative disorder of the basal nuclei due to insufficient secretion of the neurotransmitter dopamine” (Marieb & Hoehn, 2013, p. G-17). The cause of Parkinson’s disease is unknown, but many factors play a role in the development of Parkinson’s disease. One factor that has been found in an individual who has Parkinson’s disease causes over activity of targeted dopamine-deprived basal nuclei. This over activity is caused by the breakdown of neurons that release dopamine in the substantia nigra (Marieb & Hoehn, 2013). Another factor that is present in a person who has Parkinson’s disease, is the presence of lewy bodies in the brain stem ("What is lbd?," 2014). Lewy bodies are unusual

Alzheimer's disease is a broadminded disease that corrodes memory and other vital mental roles. It is the most common factor that leads to dementia which is a brain disorder that results in loss of academic and social skills. These changes can effect anyone severely enough to affect with everyday life. While having Alzheimer's disease, the brain cells corrupt and die, which causes a stable decline in memory and mental function. Currently Alzheimer's disease medications and management tactics may only momentarily progress symptoms. This sometimes helps people with Alzheimer's disease exploit purpose and preserve independence. But since there is no cure for Alzheimer's disease, it is important to seek helpful facilities as early as possible.

Currently, more than five million Americans are living with Alzheimer’s Disease. Alzheimer’s has also worked its way up to the sixth leading cause of death in the United States. Not only does this disease take the lives of the victims, but it also takes a perhaps bigger toll on the caregivers. The longer a victim lives with Alzheimer’s, the more extensive time, effort, money, and caution a caregiver has to provide. Today, there is no cure for Alzheimer’s. However, there are new treatments that slow the progression of the disease, and there are also new ways for doctors to diagnose it earlier. It is amazing that something that affects so many people is so difficult to have

Current Alzheimer's pharmaceuticals can help for a period with memory side effects and other intellectual changes. Two sorts of medications are at present used to treat subjective manifestations:

PC3 (8×104  cells/well) and LNCaP (3×105  cells/well) cells were seeded in 6-well plates in 1.5  mL of complete growth media. Cells were treated with 2.5 μM of free sorafenib or an equivalent sorafenib concentration of SMA-Sor, 3 μM of free nilotinib or an equivalent nilotinib concentration of SMA-Nilo, DMSO or SMA for 48  h. Cell cycle distribution was assessed using propidium iodide staining, as previously described {Somers-Edgar, 2011 #82}. Samples were analysed using a FACScalibur flow cytometer (BD Biosciences, San Jose, CA, USA) and the proportion of cells in each of G0/G1-, S- and G2/M-phases were determined using CellQuest Pro software (BD Biosciences, San Jose, CA, USA).

Some dopaminergic (i.e., dopamine-releasing) neurons run from the substantia nigra to the corpus striatum; their loss gives rise to the clinical manifestations of Parkinson's Disease (Korczyn 1994); others, involved in the rewarding effects of drugs and natural stimuli, run from the mesencephalon to the nucleunucleus accumbens.

Alzheimer’s disease (AD) affects everyone involved: the victim and his/her’s loved ones. First of all, caregivers are often overlooked, and never realized for what sacrifices they give up to care for their loved one. Secondly, the financial burden of caring for someone with Alzheimer’s is a big job that can hurt the opportunities that needed more time to get a better degree. Thirdly, although the victim of Alzheimer’s disease is the ill one, usually, they aren’t the only one suffering from this terrible disease. People must know that the caregivers are fighting just as much as the victim of the disease.

Alzheimer's disease, is one form of dementia that gradually gets worse over time ("What is Alzheimer’s?," 2012). It causes a decline in memory and deterioration in many other abilities ("U.S. national library," 2012). To fully understand Alzheimer’s, you must appreciate the symptom’s, diagnosis, and treatments of this terminal disease. Alzheimer’s can be described with memory loss, disorientation with time and place, and confused actions ("What is Alzheimer’s?," 2012). As the disease progresses in your body, your memory loss and motor skills deteriorate quickly.

“Alzheimer’s Disease is an incurable disease that strips you from your memory and other functions used in daily life." The brain cells degenerates and dies, which result in the patient forgetting how to perform simple daily functions like eat, sleep, walk, or talk. The size of the brain of someone with Alzheimer’s will shrink because the tissue has fewer nerve cell and connections. Studies have shown that every 67 seconds someone is diagnosed with Alzheimer’s.

Psychology is an applied as well as an academic field that studies both the human mind and behavior. The research in psychology attempts to explain and understand behavior, emotion and thought. The subject of psychology was created when Wilhelm Wundt opened up the very first psychology lab in Leipzig, Germany. Wilhelm Wundt believed that individuals who are appropriately trained would most likely be able to recognize the mental processes that are accompanied with feelings, thoughts and sensations (Wagner , 2009).

Parkinson’s disease is affected by the degeneration of dopaminergic neurons which is responsible to produce dopamine. Dopaminergic neurons have their cell bodies in substantia nigra pars compacta (SNpc) in basal ganglia (O’Sullivan and Schmitz, 2007). Basal ganglia are a collection of interconnected gray matter nuclear masses deep within the brain”. These gray matter masses are caudate, putamen, globus pallidus, subthalamic nucleus and the substantia nigra. Basal ganglia receive its input through striatum (O’Sullivan and Schmitz, 2007).