Synthesis Synthesis Lab Report

Synthesis Most ADCs contain a complex arrangement of functional groups, both on the protein and the conjugated drug molecule. These functional groups vary in bond energy, electronegativity, hydrophobicity, and charge. Below in figure 2, the simplified general layout of a typical ADC can be seen. Covalently linking the drug molecule directly to the antibody polypeptide chain, although intuitive, is not the most efficient method of synthesis. It is difficult to attach the drug molecule to a specific

Results and discussion Synthesis Synthesis involves reaction of substituted salicylic acid hydrazide 1 with substituted benzoyl chloride 2 which resulted in the formation of substituted diacyl hydrazines (3a-f). Cyclization of substituted diacyl hydrazines was carried out using Lawesson reagent, which resulted in formation of 2,5-Disubstituted-1,3,4-thiadiazoles (4a-f). 2,5-disubstituted-1,3,4-thiadiazoles undergo reaction with different aromatic aldehydes to form different novel Schiff bases. The

The purpose of this lab report is to synthesize luminol and then test its chemiluminescent properties. 5-nitro-2,3-dihydrophtalazine-1,4-dione was reduced using sodium hydrosulfite in a solution of 3 M sodium hydroxide in water to form luminol. The product was then used to chemically generate light by reacting luminol with 3 M sodium hydroxide, hydrogen peroxide, and potassium ferricyanide. The reaction created a bright, blue light emission. From glow sticks to revealing remnants of blood samples

Introduction Widely used all over the world, organic compounds, drugs, are constructed through the pharmaceutical method of organic synthesis. The most common drug is acetylsalicylic acid, known commonly as Aspirin. C_7 H_6 O_3 (s)+C_4 H_6 O_3 (aq)→C_9 H_8 O_4 (s)+C_2 H_4 O_2 (aq) In this experiment, Aspirin, along with acetic acid, was a product of the chemical reaction between salicylic acid and acetic anhydride – as shown by the chemical formula above. The product, acetylsalicylic acid, shows

Experiment 19: Synthesis of Aspirin and Oil of Wintergreen The purpose of this experiment was to employ techniques to synthesize aspirin and oil of wintergreen and to purify crude aspirin via recrystallization. Additionally, techniques were learned to determine the purity of the synthesized organic molecule of acetylsalicylic acid using a back-titration method. The objectives of the experiment were achieved by synthesizing the organic molecules of acetylsalicylic acid (using salicylic acid and

This lab could have contained errors. The errors could have happened when performing the lab. Some of the possible errors in this lab are: There might have been some mistakes made while transferring the ingredients from the beaker and the funnel to the flask and the burret. The antacid tablets were not crushed properly, resulting in big crumbs of the tablet which will affect the dissolving process of the lab. There might have been more KOH solution added to the flask resulting in the observations

method, because this method proved more efficient and economic than the physical or chemical ways 3-4. Organisms respond to heavy metal stress using different defense system, such as exclusion, compartmentalization, formation of complexes and synthesis of binding proteins like metallothioneins 5. Bacteria use the intracellular mechanism for mercury detoxification process, by reducing the Hg2+ to non toxic Hg0, by a group of mercury reductase enzyme that incorporated in the mer operon. Hg0 formed

Calculating the Molar Mass of an Unknown Compound Through the Observed Freezing Point Depression *Hardy Prosper, Aurore Folefack (Lab Partner), Jessica Potts (T.A.) Chem-112-572 Introduction Cold-tolerant fish have the ability to survive in freezing waters that would kill many other animals, due to them lowering the freezing point of water inside their bodies. This is due to the colligative property of freezing point depression, a process in which adding a solute to a solvent lowers the freezing

spectroscopy. The total yield for Benzoin was 3.506 grams which resulted in a percentage yield of 74.74%. Melting point analysis showed that the literature melting point is 134-135 ᵒC, whereas the experiment melting point was 131-133 ᵒC. In the synthesis of Benzil, 2.328 grams of crude Benzil were obtained. Thus,

a) Alcohol is absorbed straight into the blood stream and through the walls of the small intestine. Once absorbed there are some ways by which the body can get rid of it. For example, through the kidneys and urine, sweat, and some is even breathed out through the lungs (this is how breathalyzers work). However, about 90% of it is broken down by the liver. Additionally, a healthy liver will only get rid of the alcohol contained in a normal sized drink per hour. This means, when you drink more than

In the experiment, Luminol Synthesis and Chemiluminescence, the purpose is to create luminol using the base-mediated reduction of 5-nitro-2,3,-dihydrophthalazine-1,4-dione and to investigate the chemiluminescence reaction that luminol is known for. 5-nitro-2,3-dihydrophthalazine-1,4-dione was reduced using sodium hydrosulfite in a solution of sodium hydroxide under reflux conditions. Acetic acid was used to precipitate the solid luminol product, later the product was collected through vacuum filtration

Objective: To isolate trimyristin from Nutmeg and purify trimyristin recrystallization from acetone. Procedure: • Weigh out 4.00 g of nutmeg powder directly into a 50 ml Erlenmeyer flask. • Add 25 ml of diethyl ether and swirl periodically for 15 minutes. • (Do this in the fume hood) • Label a 50 ml vacuum flask and weight it to 4 places. • Support the labeled 50 ml vacuum flask using a ring stand and clamp. • Place a sintered funnel with a vacuum adaptor on the labeled flask. • Filter the solution

containing 400 mg of guafenesin each, were used. The synthesis of guaifenesin resulted in a 23.7% yield based on the theoretical value of .6207 of guaifenesin given the limiting reactant, 2-methoxyphenol. The isolation of guafenesin resulted in a 5.38% yield due to the fact the isolation was completed from two 400mg tablets of guaifenesin. HNMR and a melting point test were both used to successfully confirm that guaifenesin was the product of the synthesis and isolation methods through the location of the

Result and Discussion In this experiment, the synthesis of benzocaine was carried out by acid catalyst and recrystallization process was utilized to purify the product form impurities. The synthesis of Benzocaine was carried from 4-Amino benzoic acid (PABA) and absolute ethanol with sulfuric acid as catalyst. The reaction took place under reflux, and isolation of product was carried out by using saturated Na2CO3 and dH2O. The characterization of the product involved the NMR and IR spectrum analysis

Isopentyl was selected as the reactant alcohol used for synthesis. Acetic acid was used to react with the isopentyl, creating an acid-base reaction. Sulfuric Acid was used as a catalyst to speed up the reaction, allowing the reaction to occur over a shorter period of time. A higher concentration of alcohol was used than the acetic acid because the isopentyl was the limiting reagent. Le Chatelier’s principle states that a higher concentration of reactants causes the equilibrium of the reaction to