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The Effects Of Abuse And Related Adverse Experiences On Childhood : A Convergence Of Evidence From Neurobiology And Epidemiology

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1. Anda, R.F., Felitti, V.J., Bremner, J.D., Walker, J.D., Whitfield, C., Perry, B.D., Dube, S.R. & Giles, W.H. (2006). The enduring effects of abuse and related adverse experiences in childhood: A convergence of evidence from neurobiology and epidemiology. European Archives of Psychiatry and Clinical Neuroscience. 256: 174-186. Adverse childhood experiences (ACEs) are defined as childhood exposure to violence, danger, neglect, and/or abuse. Exposure to ACEs can result in architectural brain changes (specifically brain and corpus callosum volume, hippocampus, pre-frontal cortex, frontal cortex, and the cerebellum) that manifest in impaired brain functioning, particularly in areas of memory and learning, emotional …show more content…

For the ACE study, participants were assessed and completed standardized questionnaires in two “waves” (Anda, et. al. (2006)), that collected information regarding eight ACEs. Responses were organized based on number of ACEs and number of comorbid mental health and somatic issues. Statistical analysis revealed a strong positive correlation between the number of ACEs experienced and the number of mental health and somatic disturbances.
Limitations with the study were identified with respect to retrospective self-report measures in the face of memory difficulties (impact of stress on the hippocampus). For cases of verified ACEs, adults were deemed likely to underestimate the occurrences of ACEs.. However, findings were supported by neurobiology and epidemiological studies

2. Takahashi, H., Matsuura, M., Koeda, M., Yahata, N., Suhara, T., Kato, M., & Okubo, Y. (2008). Brain activations during judgements of positive self-conscious emotion and positive basic emotion: pride and joy. Cerebral Cortex. 18: 898-903. The researchers hypothesized that using functional magnetic resonance imaging (fMRI) they could identify the areas of the brain activated by feelings of pride (medial prefrontal cortex, posterior superior temporal sulcus, and temporal poles – the brain regions related to Theory of Mind (ToM) and empathy) and also joy (ventral striatum – the area involved in pleasure processing). They showed study participants a series of statements that had previously

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