The Evolutionary Perspective of Origination of HIV and AIDS
I. Abstract
AIDS (Acquired immunodeficiency syndrome) is disease caused HIV (human immunodeficiency viruses). This research paper describes the evolution and origination of HIV and AIDS. There are two types of HIVs. These are called HIV-1 and HIV-2. HIVs result multiple cross species transmission from SIV (simian immunodeficiency viruses) that is viruses that infects primates. HIV-1 comes from SIV from chimpanzees whereas HIV-2 comes from sooty mangabeys. HIV-1 has four sub groups these includes M, N, O, and P. Each of groups has resulted from independent cross-species transmission event. Group M is the most virulent, and it is the first to be discovered. HIV-2 has groups that ranges from A to H. SIV are infecting West Africa primates. This fact is based on the first pandemic HIV-1 has emerged in colonial West African, and most researchers have sampled primates from this region only. Newly emerged SIVs are resulted from multiple cross species transmission and recombination. The cross species transmission occurs from non-humans to humans through eating bushmeat. The cross transmission influenced by host restriction factors, but HIVs were able to pass this barriers. Most SIV are non-pathogenic to the host; however, there is some evidence that some are pathogenic to their host. The age of the virus determined by using molecular clock method. Other studies have estimated the evolutionary timescale with same age as
Scientists could predict how many people could die in a period of time. Since 1966, way before Dugas become a sexually active, scientist trace the virus not only in US, but also in places such as Haiti and Africa. Scientists took samples of blood from 1959, 1960 and bodies from 1908 they found the HVI virus in those samples. Beatrice Hahn, a professor from University of Pennsylvania, help to search for a much earlier Patient Zero, by taking it to Africa, and turning back the clock on a series of virus mutations and pinpointing with a diverse viruses such as SIV (simian immune virus), AGM (African green monkey) among many more of cross-species spillover (term scientists use to describe a moment a virus in one specie passes to other spice) in a jungle in Cameroon. A virus hunter, Nathan Wolfe, professor in human biology in Stanford University, takes it back even farther to an intracellular investigation in monkeys, gorillas, and chimps. Concluding with an intense research in chimps in a different places of West Africa, with a data, samples of major groups of HIV, and viruses from chimps created a model of “chimp Patient zero” hundreds of thousands of years
It is believed that the first case of HIV/AIDs was first recorded somewhere in West Africa somewhere in the beginning of the twentieth century. Since then, it has spread across central Africa, undetected for a long time. But the question that has bewildered many, is how HIV spread in the first place. According to “Natural Transfer Theory”, HIV was spread to humans through chimpanzees. “Africans have been killing and eating monkey for at least fifty thousand years” (43). It was common for small African communities to hunt and eat chimpanzees. Chimpanzees were said to have “SIVs, simian immunodeficiency viruses that closely resembles HIV” (41). The virus is said to have spread to humans through these infected chimpanzees. The blood of these chimpanzees could have
There are four main groups of HIV strains (M, N O and P), each with a slightly different genetic make-up. This supports the hunter theory because every time SIV passed from a chimpanzee to a human, it would have developed in a slightly different way within the human body, and produced a slightly different strain. This explains why there is more than one strain of HIV-1 The most studied strain of HIV is HIV-1 Group M, which is the strain that has spread throughout the world and is responsible for the vast majority of HIV infections today. (“origin of HIV & AIDS,”
Numerous species of monkey were infected with the Simian Immunodeficiency Virus (SIV) or Simian-Human Immunodeficiency Virus (SHIV). The macaques were the primary group of monkeys infected. “Macaques are physiologically and immunologically similar to humans so there is a significant advantage over rodents and other species. The pathogenic SIV infection of macaques can lead to a disease that is called “simian AIDS;” it is similar in many respects to the disease caused by HIV-1 in humans” (Evans and Silvestri). Using the macaques allows different treatments to occur on the experimental level that cannot be conducted in humans. The treatments have provided and continue to provide “essential information to reach a deeper understanding of the biology of HIV infection and AIDS” (Evans and Silvestri). Non-human primates are easier to use than humans do to the ability to control the timing, dose and route of the virus as well as collecting the samples from tissues that are difficult to collect from humans. Macaques can be infected by vaginal or rectal routes or by oral routes. Macaques have been used to test various “microbicides and vaccines for mucosal protection against HIV acquisition” (Evans and Silvestri). By using non-human primate models for studies of AIDS, many results have been
This book talks about how recent genetic evidence form new discoveries have traced the birth of AIDS to being rooted in the southeastern forests of Cameroon in Africa, where chimpanzees had a very similar strain of Human Immunodeficiency Virus in their blood. They carried this simian immunodeficiency virus for hundreds of years without creating any major, large-scale outbreak in humans. The birth origin story of HIV may have been happened sometime around 1880 to 1920. TImberg and Halperin discuss that the birth of HIV most likely occurred when a European hunter traveling in
One example of Darwin’s idea is a much more recent discovery relating to HIV. Today’s scientists and researchers can actually see the process of natural selection in front of their own eyes, which is something that, unfortunately, Darwin could not do. Once HIV is inside the white blood cells of a patient, the disease reproduces briskly, which causes causes mutations. Every time after the cell reproduces and drugs are administered to the patient, the drugs go in and attack the weak cells, killing them off, but the virus dominant ones win over the drug, eventually becoming almost immune to them. Each time a new drug is administered, the virus evolves to resist it. This is proof of evolution, regarding how the virus evolves over time, and proves
As previously stated HIV is a lent virus that attacks the immune system. In comparison SIV (Simian Immunodeficiency Virus) attacks the immune system of monkeys. So the question is: Did HIV in fact come from monkeys? A strain of SIV (called SIVcpz) was found in a chimpanzee upon research in 1999. This strain can infect humans and also be passed on from chimpanzee to chimpanzee. In conclusion the most reasonable transferring theory is based off of hunting. The SIV was transferred to humans as a result of the chimps infected blood and them be eaten. Then the virus migrated and transformed in what we know today as
According to (Avert.org) “In 1999, a strain of SIV (called SIVcpz) was found in a chimpanzee that was almost identical to HIV in humans.The researchers who discovered this connection concluded that it proved chimpanzees were the source of HIV-1, and that the virus had at some point crossed species from chimps to humans”
This paper breaks down and defines what SIV is, the different subfields involved, and which species they originate from. The zoonotic transmission of the SIV virus from these non-human primates is discussed as well. As a result of these transmissions, the human immunodeficiency virus is brought to life. In this paper, this virus and its journey throughout history will be explained. Also, HIV and the different subfields this virus can be classified in are discussed throughout the research. As well as the where this virus was contracted, about the time when, and how it was possible. Also, the modern day methods of contracting this virus are listed in detail throughout the paper. The process of contraction of HIV through zoonotic transmissions is elaborated. An estimate on just how many of these animal-to-human transmissions that happened leading to HIV/AIDS is given. Lastly, the causes of how this virus was spread globally are broken down and explained each step of the way. This paper uses scholarly journals as references from a few different sources, including: Proquest, Academic OneFile, and Google Scholar.
Unlike the plague, the Human Immunodeficiency Virus is species specific and has puzzled many scientist about the possibility of overcoming its harsh implications. This mean that HIV can be found only within a particular species and, in this case, this virus tends to attack the human race. Many blame that the very existence of AIDS emerged from gay people or relations with animals, but it’s believed that transmission of this virus originated from a close derivative of HIV, SIV. SIV in known as Simian Immunodeficiency Virus which the Monkey virus that is equivalent to HIV. It has been known that the development of AIDS started with the transmission of SIV to humans via being bitten by a primates or the consumption of a primate who is infected
HIV is a quite detrimental virus that has caused much disruption during the 1980’s when it came to life. HIV is “one of the fastest evolving of all organisms” (Rambaut A. ET. Al. 2004) HIV has found ways in which to resist drugs and shows evolutionary mechanisms. The HIV virus has also
Many people think that the origin of HIV, the AIDS virus, procures from natural evolutionary event. But, there is a theory called “cut hunter theory” in which a human, allegedly, African native, be given a infected splash while fighting with a chimpanzee carrying a similar to HIV virus. Although, most recent research holds that the origin of HIV and AIDS could never have happened this way. Others says that AIDS started in 1980s in the united states of America, but this was just when people first became aware of AIDS and it was a new health
It resisted treatment because it could quickly develop new varieties which survive newly created drugs. Here was evolution taking place right before our eyes, affecting people whose names we knew. The chain of contagion was traced back to West Africa. But what had given birth to the first HIV? DNA analysis showed that it was descended from simian immuno-virus (SIV), with which monkeys in the area had been infected for thousands of years.
The origin of HIV-1 is a closely related chimpanzee virus that first infected humans in Central Africa in a first half of the 20th century (Cachay 2016). Some of the events that together made up rapidly enlarging and increasingly interconnected pools for transmission of pathogens during 1960-1970 were blood product industries, IV drug use, the sexual
Curbing the spread of HIV has been a major goal since its emergence of the disease in 1981 in the sub Saharan Africa (http://www.unaids.org) . There are two viral strains that cause Acquired immunodeficiency syndrome (AIDS) in humans, human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2). They have both resulted from the multiple cross species transmission of simian immunodeficiency virus that infects primates