Saturday 26th December 2015: Interpretation and QC
The first part of this learning topic, Biovariation and Reference Ranges, was review but many of the examples given were new to me. I found very interesting read about Quality Assurance and Quality Control as they are topics that I know little of. And It was really useful the “Basic Lessons in Laboratory Quality Control” to know more of QC and how to construct and interpret quality control charts.
To report the correct result is essential to have a good program of quality control (the operational techniques and processes that are used to fulfil the needs for quality), quality assurance (the overall systematic monitoring and evaluation of a product or service to ensure that standards of quality are satisfied) and quality assessment (internal or
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Caffeine can increase renin, catecholamine and free fatty acid levels. Caffeine stimulates the adrenal medulla causing and increased excretion of catecholamines. Caffeine also has a diuretic effect which stimulates the release of renin.
Alcohol consumption can lead to increases in liver enzymes such us γGT, AST and ALT because alcohol is metabolised in the liver. HDL levels increase (possibly due to an increase in the transport rate of apoliproteins A-I and A-II which raises HDL concentration) and serum osmolality (because of an additional substance in the serum). Alcohol reduce serum levels of prescribed drugs (chronic alcohol consumption can active drug-metabolising enzymes which decrease the drug’s availability hence diminishing its effects).
Statins can affect liver enzymes, increase γGT and creatine kinase.
IV fluids – if blood samples are taken from the same arm in which IV fluids were administered then this can cause false levels of some analytes. For example, dextrose can cause increased levels of glucose in blood and urine. Saline can affect electrolyte results, i.e. causing raised levels of sodium and
The pathophysiology of Alcohol affects virtually every organ system in the body. Therefore, consuming to much alcohol in high
The purpose of this lab was for the student to get involved with his or hers new lab kit as well as being able to know, identify and use each other tools provided in the kit. Another key learning aspect of this lab is to teach the student how to measure properly the many units in the SI system. I will be using laboratory dilutions, measurements, and weights to then calculate using algebraic formula.
Caffeine, sugars and many more provide energy by stimulating the central nervous system giving the body a sense of alertness. It can raise heart rate and
The end result is an increase in blood sugar for use as muscle fuel. Basically, it is believed that caffeine raises the general metabolism of the user, which resultantly increases the activity and raises the body’s temperature (wysiwyg://35/http://onhealth.com/ch1/indepth/item/item.34623_1_1.asp).
The pathophysiology of alcoholism begins after alcohol the ingestion of alcohol. It is absorbed and unaltered through the stomach and intestines. Next it is distributed throughout the body through the blood and absorbed by all tissues and fluids (Huether, 2012, p. 72). Furthermore, in the liver the alcohol blood content is metabolized into acetaldehyde by the enzymes process of alcohol dehydrogenase (ADH), the microsomal ethanol oxidizing system (MEOS), and catalase (Huether & McCance, 2012). Next, the metabolizing effects the central nervous system (CNS) and exhibits a depressant action. It is first expressed in the subcortical structures of the brain. This has an effect of disorientation of motor skills and intellect. With an increase in blood alcohol concentration, the medullary centers become depressed and as a result affects respiration (Huether & McCance, 2012). In addition, the effects of alcoholism encourage hepatic and gastric changes. The hepatic effect is caused by acetaldehyde, in which, induces inflammation, fatty deposits and enlargement of the liver (Huether & McCance, 2012).
The liver is next to be severely impacted by alcohol. The liver is fundamental to the process of maintaining a healthy system. “The liver stores vital energy and nutrients, manufactures proteins and enzymes necessary for good health, protects the body from disease, and breaks down and helps remove harmful toxins, like alcohol, from the body.” (Sutton, 2007) If the liver becomes damaged, the person will develop muscle cramps, fatigue, jaundice, and even reduced brain function due to unfiltered toxins in the blood stream.
The Health assessment of an alcoholic is far worse as they can suffer from a number of health complications and diseases that are associated with alcoholism such as liver disease, alcohol induced pancreatitis, cancer and cardiovascular disease (Rehm136). Not to mention the many types of injuries that be sustained while intoxicated, such as alcohol poisoning, broken limbs, or blackouts (137).
While alcohol may have damaging effects to one’s body, many benefits exist if one drinks responsibly. Many studies and cases do show alcohol can damage the liver and other parts of the body; however, when one drinks in a moderate manner many health benefits may exist. Alcohol helps to fight against various health conditions and risks common among many people,
~ Alcohol interferes with essential nutrients, it drains vitamins in body and slows absorption of new ones.
Heart Disease: A lot of studies have been done on the relationship between caffeine and heart disease. While scientists don't believe it is a primary cause of these diseases, it can make all of them worse. Caffeine raises blood pressure, causes angina attacks and can cause difficulties in those who have murmurs.
Caffeine (C8H10N4O2) in it chemical nature is a central nervous system stimulant which acts by dilating blood vessels and preventing adenosine from inhibiting the release of glutamate. (Oxford University Press, 2016) Caffeine as a widely used drug, is frequently studied in regards to its performance and physiological effects on an individual. (Harland, 2000)
When you consume alcohol, your liver must break down the alcohol. When heavy drinking occurs, the liver can become fatty. When you have a fatty liver, you are more susceptible to inflammation in the liver which leads to less blood flow. When the cells in the liver aren’t getting enough blood, they lack nutrients and will eventually die and be replaced with scar tissue. Without these cells the liver is slowly becoming less and less efficient at its job. In some cases, the liver can function
"The long term effects of alcohol on the body include liver disease, various cancers, heart disease, high blood pressure, stroke, diabetes, memory loss and death." (It Makes You Think...the Invisible Effects of Alcohol). Over time, the intake of too much alcohol causes one's body to shut down. One of the vital organs that's needed to live is the heart. The heart preforms many functions including the pumping of the blood through the veins in order to receive oxygen and maintaining a steady heartbeat. The average heavy drinker will cause effects on the heart including uncommon heart patterns and demolishing the heart muscle. Another important organ that liquor damages is the liver. People need their liver in order for the human body to function properly. "The liver is so important that humans can only survive one or two days if it shuts down." (Sharon R. Kaufuman) Alcohol increases the chances of that happening; and heavy use of alcohol "causes the liver to become scarred (known as cirrhosis) and it can cause permanent damage which also can lead to death." (Alcohol-Related Liver
The Health concerns of consuming alcohol are unacceptable. Because you are consuming, sometimes unsafe, amounts of alcohol your liver is affected by it. Alcohol damages liver cells and your liver is an important organ with a role in your body. It also causes heart disease. It raises your blood pressure and when your blood pressure rises, then you have a chance of heart attack or stroke. Blood pressure can also make you gain weight.
Alcohol has no beneficial attributes on a person’s health. Alcohol can have several harmful effects on human organs. Some organs in the human body that are damaged by alcohol consumption are the brain, kidneys, and liver. The human liver is the one organ that suffers the most damage. As stated in an article published by the National Institute on Alcohol Abuse and Alcoholism, “Because the liver is the chief organ responsible for metabolizing alcohol, it is especially vulnerable to alcohol – related injury” (NIAAA, 2005). Regular use of alcohol can lead to alcoholic liver disease (ALD). The severity of ALD can vary based on several different factors. Some of these factors include gender, age, the amount consumed, and how often alcohol is used. “ALD includes three conditions: fatty liver, alcoholic hepatitis and cirrhosis” (Alcohol Alert, 2005).