Orthopaedic Surgery (2010), Volume 2, No. 3, 201–206
ORIGINAL ARTICLE
Clinical research on the bio-debridement effect of maggot therapy for treatment of chronically infected lesions os4_87 201..206
Shou-yu Wang MD1, Jiang-ning Wang MD2, De-cheng Lv MD1, Yun-peng Diao PhD3, Zhen Zhang MD1
1
Department of Orthopedic Surgery, The First Affiliated Hospital, 3Department of Pharmacy, Dalian Medical University, and 2Institute of Reconstructive Surgery, Dalian University, Dalian, China
Objective: To evaluate the bio-debridement effect of maggot therapy for treating chronically infected lesions. Methods: A retrospective study was conducted of 25 patients with diabetic foot ulcers and 18 patients with pressure ulcers after spinal
…show more content…
The patients who were agreeable to maggot therapy were required to sign an informed consent form.
Preparation of maggots
Firstly, eggs were collected from the eyes of Scomberomorus niphonius and disinfected in 1% sodium sulfite solution for 3 min, and subsequently in 3% Lysol brand disinfectant for 5 min. The disinfected eggs were then transferred to sterile vials to clone. Secondly, third stage larvae of Lucilia sericata were selected to be placed in 3.5% formalin for 5 min, 2% hydrogen peroxide solution for 3 min, and then 5% dilute hydrochloric acid solution for 5 min. After the two-step disinfection, the larvae remined vigorous. A hundred randomly selected larvae were proven to be aseptic by bacterial culture test.
Treatment
After two-step disinfection, disinfected larvae were applied to the lesion.
Wagner- Meggitt’s classification scale was introduced in 1970s and widely accepted, universally used grading system for lesions and diabetic foot. The original scale has 6 grades of lesions. The first four grades (grade 0, 1, 2, & 3) are used on the physical depth of the lesion in and through the soft tissues of the foot. The last two grades (grade 4 & 5) are completely distinct because they are based on the extent of the gangrene and lost perfusion in the foot. Grade 4 refers to partial foot gangrene and grade 5 refers to completely gangrenous foot. In this study the scale is not much of useful because the grade 3, 4 and 5 are not come under inclusive criteria. For easy understanding there are only grade 1 and grade 2 are taken and most of
The medicine is applied from the neck, all the way down and must be left on for at least eight hours. You can also kill the mites from using oral medications. Some medicines are Permethrin cream, Lindane lotion, Crotamiton also know as Eurax, and Ivermectin also known as Stromectol. Crotamiton is available as a cream or a lotion and it's applied once a day for two days. As for Ivermectin, doctors usually prescribe this oral medication for people who have altered immune systems, or for the people who don't get results from the prescription lotions and
The process of wound assessment requires accurate and appropriate interventions while dealing with the patients. There are some major components which the operator must consider to effectively access an infection, and they require a range of skills and knowledge. These factors are the knowledge of relevant anatomy and physiology, the understanding of the various factors that accelerate wound growth, and the ability to listen and understand the patient’s needs. In wound accessing, the doctor should have an idea concerning the number and location of wounds, the required treatments depending on the type of infection, the type of wound in accordance to various grading given, and the procedures to follow to achieve the treatment
The aim of treatment of wound management in Mr BW was to safely allow the exudation of pus to drain freely from the wound in order to expedite wound healing. At the same time, to consider the level of comfort, prevent further infection, increased mobility and ensure nutritional
Kangovi, ., MD, MS, Mitra, N., PhD, Grande, D., MPA, Huo, H., PhD, Smith, R,.A., BS, and Lon , J. A., MD. (2017).
The first couple of paragraphs include an explanation of what is considered a complex wound and the current available treatments. It is beneficial that the authors include an explanation of what the problem is so that the reader can have a better understanding of why this issue is of concern. The paragraphs then transition towards the types of treatments available for the problem and a description of why the current treatments are not sufficient for restorative care.
The clinical issue to be explored is the use of negative pressure wound therapy (NPWT) in the treatment of ulcers. A valuable journal containing articles pertaining to this topic is the International Wound Journal. It is a peer-reviewed journal used by various healthcare providers, including nurses, doctors, podiatrists, surgeons and others, seeking to gain up-to-date information on the prevention and treatment of wounds (Wiley Online Library). It has aided in enhancing the standards provided in wound care by health care professionals. Examples of subject matters covered are diabetic wounds, burn wounds, scar prevention and treatment, wound healing therapies, education and training and more (Wound Source). The journal is therefore
Further Infection due to the effects of age, location of the wound, malnourishment, and diabetes mellitus.
The ANTT may be used by nurses when they are cleansing wounds or changing dressings. Wounds healing by primary or secondary intention should be approached in the same manner whether the wound is open or closed ensuring asepsis throughout. A solution that is non-toxic to the tissue is used to remove debris, wound exudates and metabolic wastes, these processes are used to cleanse the wound and help to promote wound healing (Briggs 2008). The ANTT should be adopted when attending to surgical site wounds, pressure ulcers, diabetic foot ulcers, leg ulcers and less superficial wounds such as skin tears and scrapes where the integrity of the skin has been breached or compromised
Chen, J., Zhang, C., Jiang, H., Li, Y., Zhang, L., Robin, A., . . . Chopp, M. (n.d.).
The next step involves the collection of the insects and beetles from the body and scene. Adult flies should be caught with a net, and then immobilized in a glass killing jar consisting of a cotton ball soaked in ethyl acetate. After a few minutes the adult flies can be transferred to vial with 75% ethyl alcohol. For the collection of beetles, using forceps or gloved fingers beetle can be placed directly into a vial of 75% ethyl alcohol. The next step is the collection of eggs and approximately 60 larvae from the maggot mass. These can be placed in a killing solution or ethyl alcohol. For multiple sites of maggot colonization, samples should be taken separately. The process should be repeated for obtaining live, non-preserved
The wound site of patients with chronic foot ulcers were rinsed with normal saline, natural honey was applied to the wound and covered with glycerin- impregnated gauze. Patients were followed on a daily basis for four weeks.
This statement is supported by an abundance of evidence from level 1 and 2 studies gathered from a comprehensive review of maggot therapy and individuals with venous ulcers.1,2,3,4,5 Maggot therapy treatments have yielded 95% confidence intervals of 1.65-3.251 in regards to decreasing debridement time. Multiple studies discovered that 45.5%-96.9% of the wound was debrided following one treatment of maggot therapy compared to only 33.5-39.4% after conservative treatment.2,3,5 Clinical and statistical significances are evident regarding debridement time when comparing maggot therapy and conservative treatment options including; hydrogel (P<0.001)1,2 and surgical debridement (P=0.04).3 The application of maggot therapy; 1-2 treatments/week1,2,3,4,
On-top of this the management of MRSA requires infection control, offloading, adequate vascularity, and meticulous wound care. A surgical option could be through maggot therapy. This is the debridement of necrotic tissue with sterile fly larvae and clinical trials suggest it is very effective in relation to MRSA. Maggots can provide a cost-effective alternative to conventional treatments, but the therapy become very unpopular with the introduction of antibiotics.
GraftJacket is one of the commercial wound dressing suitable for diabetic foot ulcers, repair and replacement of damaged or inadequate integumental tissue.It has a regenerative tissue matrix derived from human tissue, that been through different processes to eliminate the cells and destroy pathogens.The matrix acts as an immunologically inert