1. Introduction According to the CDC about 2.5 million of the 10.5 million deaths worldwide per year among children (age < 5yrs) are caused by diseases for which vaccines are available [1]. Before the middle of the last century, diseases like whooping cough, polio, measles, haemophilus influenzae, and rubella struck hundreds of thousands of infants, children and adults in the U.S. [1,2]. Thousands died every year from them [1]. As vaccines were developed and became widely used,
