For many years the questions has been raised as to why not all children are affected by Foetal Alcohol Syndrome even if the mother was drinking alcohol during her pregnancy. The theory that genetics plays a role in whether a child will have FAS first came about through studying twins. In a sample size 16 sets of twins, which were all exposed to alcohol while in the uterus, out of the 5 sets of identical twins, in each set both children were affected by FAS. Out of the 11 sets of fraternal twins, 4 sets had the same out come as the identical twins, while in the other 7 sets only one child per set was affect by FAS. Through this research it can therefore be understood that it was the difference in DNA of the fraternal twins that lead to only …show more content…
Another area of study is that if the mother has both or one of the alleles ADH1B*2 and ADH1B*3 her child is protected from FAS. ADH1B*2 and ADH1B*3 are polymorphisms of ADH1B which comes from the alcohol dehydrogenase (ADH), which is a catalyzing enzyme involved with the oxidation of ethanol. These alleles code for enzymes that cause oxidation of ethanol to occur at a much faster rate than usual. By having a faster oxidation rate alcohol will be metabolized and detoxified sooner. The alcohol consumed goes into your blood stream and is spread through the body, which could have a teratogenic effect on the foetus, until the alcohol has been completely metabolized. Therefore the faster the alcohol can be metabolized the less chance there is of it getting to the placenta and therefore into the foetus’ bloodstream. Due to the fact that the alcohol won’t be able to get to the foetus because it oxidised much quicker, the foetus is protected from the effects of the alcohol which lead to FAS.
The most recent discovery to provide evidence that genetics is a contributing factor to the development of FAS is the discovery of the exact locus that controls the alcohol sensitivity of the L1 protein. L1 is an essential part of the neural development of foetuses. It is located on the outside of cells and is important to the joining of cells as well as axon control and movement of cells. Phosphorylation, controlled by the enzyme ERK2, occurred inside the L1
The science behind FAS is quite simple; as it is known that alcohol has a damaging effect on the body, it has similar consequences on the fetus. Since the fetus is constantly developing, the alcohol causes more serious defects to the unborn child. Alcohol exposure to a fetus is known as a teratogen. “Teratogens are substances or conditions that disrupt typical development in offspring as a result of gestational exposure and cause birth defects.” (Wilson & Fraser, 1977). Although the exposure to alcohol causes problems in the fetus, studies have shown that it may not accurately be the alcohol in the mother’s system that causes these defects, rather the byproducts that form when the body metabolizes the alcohol. This can lead to a decrease in brain cells, abnormal location of neurons, and gross malformation to the brain. Since alcohol causes this central nervous system damage, it is classified as a neurobehavioral teratogen, which is a group of teratogens that cause brain damage and modify behaviors. (Riley & Vorhees, 1986). The CNS damage is the primary defect due to alcohol and it is quite common to have these damages without any physical abnormalities. The more alcohol that is consumed the more birth defects that will arise in the
Alcoholism is a real threat to pregnant women. In particular, there is a huge rise in Fetal Alcohol Syndrome (FAS) cases, which is when an unborn fetus actually becomes addicted to and dependent on alcohol passed from the mother. In 1996, only 0.5 to 3.0 cases were confirmed for every 1,000 pregnancies, but today, that number is a staggering 20 to 50 cases per 1,000
Fetal alcohol spectrum disorder (FASD) is a concise, uniform definition for conditions caused by prenatal alcohol exposure. FASD is a broad term used to describe the range of effects that can occur in an individual whose mother drank alcohol during pregnancy (Caley, Kramer, & Robinson, 2005). Fetal alcohol spectrum disorder can also cause growth retardation, birth defectscomma and deficits in cognitive, languagecomma and motor development (Coles et al., 2015). Fetal alcohol spectrum disorder is a teratogenic effect, which is caused by daily, chronic, heavy and frequent alcohol use while in utero. Chances of an infant diagnosed with FASD are 0.5 to 3 in 1,000 live births (Cone-Wesson, 2005). Fetal alcohol spectrum disorder has many different diagnoses. There is fetal alcohol syndrome (FAS), partial fetal alcohol syndrome (PFAS)comma and alcohol-related neuro-developmental disorder (ARND)comma all under the fetal alcohol spectrum disorder umbrella (Brown et al., 2015). Maternal alcohol use is correlated to the timing, frequencycomma and quantity of the consumption of alcohol during pregnancy. Drinking during the first trimester may not be as detrimental as drinking during the second or third trimester. The frequency of alcohol consumed is also a key factor in FASD, such as how often per day drinks are consumed, the quantity of alcohol consumed, and how many glasses or cans per day the mother consumes
According to Seaver, Fetal Alcohol Syndrome (FAS) is birth defects causing learning, and behavioral problems in individuals whose mothers drank alcohol during pregnancy. This disorder is very serious, yet it is recognized as one of the most preventable. This causes major issues, when something so serious could be prevented but is not. Fetal Alcohol Syndrome is a problem because it leaves a permanent effect on the unborn child, but some solutions could be educating women and putting up more informational posters and warning labels on products.
Fetal Alcohol Syndrome (FAS) is a combination of physical and mental birth defects. When a pregnant woman drinks alcohol she is making her child drink also. However, alcohol itself may not be directly responsible for all (or any) of the features of FAS. What may be responsible are
“Fetal Alcohol Spectrum Disorder (FASD) is an umbrella term describing the range of effects that can occur in an individual whose mother drank alcohol during pregnancy. These effects may include physical, mental, behavioral, and/or learning disabilities with possible lifelong implications” (HHS, 2005). FASD refers to conditions such as: fetal alcohol syndrome including partial FAS, fetal alcohol effects (FAE), alcohol related neurodevelopment disorder, alcohol-related birth defects. The conditions that are involved with FASD can range from mild to severe and it is not likely that two people share the exact same symptoms.
As stated earlier, alcohol has its greatest effect on the developing embryo during the first trimester of pregnancy with its teratogenic effect causing mental retardation as well as characteristic craniofacial abnormalities that are characteristic of the disease. It has also been demonstrated with experimental animal models that there is a clear "dose-response" effect between the amount of alcohol consumed by the mother and the risk that is associated with developing FAS symptoms (Walpole, p. 875). It has been proposed by Walpole and associates that there are various degrees to which the fetus An be effected. Walpole uses the term "fetal alcohol syndrome" to refer to serious effects due to heavy maternal drinking and "fetal alcohol effect" to refer to those effects thought to occur with lower maternal alcohol intake (Walpole, p. 875). Regardless of the degree to which
Every year, about 40,000 babies are born with symptoms of prenatal alcohol exposure (Lupton, 2003). This number will only continue to grow if the risk of drinking alcohol while pregnant is not brought to the people’s attention. When the mother takes a drink of alcohol, so does the fetus, which will cause physical and behavioral problems after birth. Fetal Alcohol Syndrome (FAS) is completely preventable and irreversible. FAS awareness and prevention is important; expectant mothers need to know the background information about the syndrome, some common symptoms, signs, and treatments, and the mental and physical abnormalities that will occur because of this lifelong syndrome.
Fetal Alcohol Syndrome (FAS) is a disorder that occurs when a mother consumes alcohol while pregnant. Individuals with FAS may face many problems such as, bad vision, hearing impairments, memory difficulty, communicative hurdles, and much more (Bergen & Yu, 2012). In began in 1981 when expecting mothers were advised not to drink while pregnant (Alcohol Policies Project, n.d). However, is 1995 4 times more mothers were consuming alcohol in comparison to a few years earlier in 1991 (Alcohol Policies Project, n.d). In addition, 52 percent of women ages 18-34 claimed to have been consuming alcohol while pregnant (Alcohol Policies Project, n.d). The reason for a mothers decision to drink is unknown, it could possibly be that mothers have read reports
Some studies suggest that women who only consume one alcoholic beverage per day increase their risk of FAS. Every time that a woman drinks, the alcohol travels from her bloodstream to the placenta. The baby gets his or her nourishment through the placenta. A baby's body breaks down alcohol at a slower rate than an adult's. The best way to prevent FAS is not consume any alcohol while you are pregnant.
pregnancy. FAS is unique in that effects on the children are directly linked to maternal drinking
Fetal Alcohol Syndrome (FAS) refers to a group of physical and mental birth defects resulting from a women’s drinking alcohol heavily or at crucial stages during pregnancy. Fetal Alcohol Syndrome was first named and treated in the late 1960's. This condition results from the toxic effect of alcohol and its chemical factors on the developing fetus. FAS is the leading cause of mental retardation occurring in 1 out of every 750 births. The frequency of FAS occurs about 1.9 times out of every 1000 births according to the latest figures, and minor effects can be seen in up to 20% of pregnancies per year. This number changes drastically for women who are clearly alcoholics. As high as 29 children out of every 1000 births will suffer from FAS
Fetal Alcohol Syndrome (FAS) was found, named and treated in the late 1960’s. The term “Fetal Alcohol Syndrome” is used to describe a lifelong set of physical, mental and neurobehavioral birth defects associated with alcohol consumption during pregnancy.
FAS or fetal alcohol syndrome is a severe form of fetal alcohol spectrum disorder (FASD), and the effects of this condition are usually permanent. There are a wide range of symptoms and these are just a few: a small head, smooth ridge between the upper lip and nose, small and wide-set eyes, very thin upper lip, or other abnormal facial features and below average height and weight. (The Healthline Editorial Team). 2015. Another factor that may affect the fetus and the baby in future development is stress. When you’re stressed, your body goes into "fight or flight" mode, sending out a burst of cortisol and other stress hormones. These are the same hormones that surge when you are in danger. They prepare you to run by sending a blast of fuel to your muscles and making your heart pump faster. (Watson, S). 2013. Some studies show that chronic stress may lead to low birth weight, and this is when you alter your bodies stress management system. And based on what I have read I do feel that lower stress levels outweigh the minor risks of controlled alcohol consumption. This is due to the fact that there have been no studies that directley link moderate alcohol consumption to birth defects. FAS has been linked to mothers who abused alcohol during
It can not be explained why one fetus with exposure to alcohol during pregnancy can be born with no disabilities while another with similar exposure can be born with fetal alcohol syndrome (FAS)