1. Describe the morphological phenotypes you see in the experimental conditions, in comparison to the control condition. 2. Speculate what mutation or treatment could have caused the observed phenotype, and explain why. 3. Predict the functional consequence such morphological phenotype could have on mitochondrial functions, as well as its effect on cellular health and function. Case 4: Electron microscopy images in the WT show normal tubular mitochondria, while the mutant has a “mitochondria-on-a-string” appearance. Immunofluorescence images show Drp1 (green signal) association throughout mitochondria (red signal), while the mutant show more Drp1 association around the “string” region. The thickness of the string is consistent with the size of the constriction ring formed by Drp1-oligomer.
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1. Describe the morphological
2. Speculate what mutation or treatment could have caused the observed phenotype, and explain why.
3. Predict the functional consequence such morphological phenotype could have on mitochondrial functions, as well as its effect on cellular health and function.
Case 4: Electron microscopy images in the WT show normal tubular mitochondria, while the mutant has a “mitochondria-on-a-string” appearance. Immunofluorescence images show Drp1 (green signal) association throughout mitochondria (red signal), while the mutant show more Drp1 association around the “string” region. The thickness of the string is consistent with the size of the constriction ring formed by Drp1-oligomer.
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