1. What is the possible condition of the patient? 2. Are the leukocyte count and differential count normal? 3. What is the probable ethology of this disorder? 4. What are the immunologic/serologic manifestations of infection? 5. Are there any laboratory test that would further support the infection?
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1. What is the possible condition of the patient?
2. Are the leukocyte count and differential count normal?
3. What is the probable ethology of this disorder?
4. What are the immunologic/serologic manifestations of infection?
5. Are there any laboratory test that would further support the infection?
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- A 39-year-old man with a history of bacterial endocarditis notices numerouspinpoint hemorrhages around the orbit of his eyes (shown in the image; seearrows). What is the appropriate term used to describe this form of superficialhemorrhage. A- EcchymosisB- ErythemaC- PetechiaD- PurpuraA nine-year old boy with HbSS disease presents with pain in his right leg. The complete blood count shows: Hb 7.5 g/dl; WBC 25x10 /L; PLT 300x10 /L. The MOST appropriate investigation to aid with his diagnosis is: a. PT / PTTb. Reticulocyte countc. ESRd. ASOTBACKGROUND A 2-year-old black girl is being seen by the hematologist after her pediatrician found her to be severely anemic with splenomegaly and jaundice. Her mother gives a possible history of a “blood problem” in her family but doesn’t know for sure. Her hemoglobin electrophoresis was normal, and the complete blood count (CBC) revealed a normocytic anemia. The platelet and white blood cell counts are normal. On the peripheral smear, there are many bizarre erythrocytes, including spiculated cells. A diagnosis of pyruvate kinase deficiency is made. Pyruvate kinase deficiency (PKD) can be inherited in an autosomal recessive manner, which means that a child must inherit a gene with the disease-causing mutation from both parents in order for the disorder to be inherited. The PLKR gene regulates the synthesis of the pyruvate kinase enzyme, which is located in the liver and red blood cells. Pyruvate kinase deficiency (PKD) is a rare genetic disorder characterized by the premature…
- Clinical history: A 52-year-old homeless, alcoholic man had a fever and a cough productive of thick sputum that worsened over several days. His temperature is 38.2°C. Diffuse crackles are heard at the right lung base. Laboratory studies are as follows: hemoglobin: 13.3 g/dL, hematocrit: 40%, platelet count: 291,8000/mm3, WBC count: 13,240/mm3with 71 segmented neutrophils, 7% bands, 16% lymphocytes, and 6% monocytes. Sputum sample stain photo. What technique would you use to put the sputum sample on the slide? How would you stain the slide? What PPE should you have on while working in the lab? When noting the results above, what would be the correct way to report the results? Looking at the stain, what microbe might be the causative agent? No references, just homework Please include referencesA 45-year-old man noticed multiple pinpoint red spots and bruises on his arms and legs. The hematologist confirmed the presence of petechiae, purpura, and ecchymoses on his extremities and ordered a complete blood count, prothrombin time, and partial thromboplastin time. The platelet count was 40 x 109/L, the mean platelet volume was 12.2 fL, and the diameter of platelets on the Wright-stained peripheral blood film appeared to exceed 6 mm. Other complete blood count parameters and the coagulation parameters were within normal limits. A Wright-stained bone marrow aspirate smear revealed 10 to 12 small unlobulated megakaryocytes per low-power microscopic field. Do these signs and symptoms indicate systemic (mucocutaneous) or anatomical (soft tissue) bleeding? Why?A 45-year-old man noticed multiple pinpoint red spots and bruises on his arms and legs. The hematologist confirmed the presence of petechiae, purpura, and ecchymoses on his extremities and ordered a complete blood count, prothrombin time, and partial thromboplastin time. The platelet count was 40 x 109/L, the mean platelet volume was 12.2 fL, and the diameter of platelets on the Wright-stained peripheral blood film appeared to exceed 6 mm. Other complete blood count parameters and the coagulation parameters were within normal limits. A Wright-stained bone marrow aspirate smear revealed 10 to 12 small unlobulated megakaryocytes per low-power microscopic field. Is the thrombocytopenia the result of inadequate bone marrow production? Explain why. Do these signs and symptoms indicate systemic (mucocutaneous) or anatomical (soft tissue) bleeding? Why?
- Mr. Alvis, age 57, presented to his physician with marked fatigue, nausea with occasional diarrhea, and a sore, swollen tongue. Lately he also has been experiencing a tingling feeling in his toes and a feeling of clumsiness. Microscopic examination of a blood sample indicated a reduced number of erythrocytes, many of which are megaloblasts, and a reduced number of leukocytes, including many large, hypersegmented cells. Hemoglobin and serum levels of vitamin B12 were below normal. Additional tests confirm pernicious anemia. Discuss other tests that could be performed to diagnose this type of anemia.Mr. Alvis, age 57, presented to his physician with marked fatigue, nausea with occasional diarrhea, and a sore, swollen tongue. Lately he also has been experiencing a tingling feeling in his toes and a feeling of clumsiness. Microscopic examination of a blood sample indicated a reduced number of erythrocytes, many of which are megaloblasts, and a reduced number of leukocytes, including many large, hypersegmented cells. Hemoglobin and serum levels of vitamin B12 were below normal. Additional tests confirm pernicious anemia. Discuss the treatment available and the limitations.Mr. Alvis, age 57, presented to his physician with marked fatigue, nausea with occasional diarrhea, and a sore, swollen tongue. Lately he also has been experiencing a tingling feeling in his toes and a feeling of clumsiness. Microscopic examination of a blood sample indicated a reduced number of erythrocytes, many of which are megaloblasts, and a reduced number of leukocytes, including many large, hypersegmented cells. Hemoglobin and serum levels of vitamin B12 were below normal. Additional tests confirm pernicious anemia. Question 1 Relate the pathophysiology of pernicious anemia to the manifestations listed above.
- Select the correct answer for each question. Explain why you chose that answer as opposed to the others. In other words, explain why the other choices are incorrect. Hemolytic disease of the newborn will NOT be possible in which of the following situations listed below? If the father is Rh- If the child is type O positive If the father is Rh+ If the child is Rh+With the results below, do you think the patient requires a transfusion? Using current guidlines to support your answer , explain your reason. Investigation Result (normal range - female) Haematology Red cell count (x 1012/L) 4.0 (3.8 – 5.8) Haemoglobin (g/L) 123 (115 – 165) White cell count (x 109/L) 8.1 (3.6 – 11.0) neutrophils 2.9 (1.8 – 7.5) lymphocytes 4.5 (1.0 – 4.0) monocytes 0.62 (0.2 – 0.8) eosinophils 0.10 (0.1 – 0.4) basophils 0.02 (0.02 – 0.1) Platelets (x 109/L) 138 (140 – 400) Prothrombin Time (s) 20 (10 – 14) Activated Partial Thromboplastin Time (s) 45 (22 – 36) Biochemistry Serum Bilirubin (µmol/L) 50 (≤21) Serum ALP (IU/L) 300 (30 – 130) Serum AST (IU/L) 527 (≤32) Serum ALT (IU/L) 650 (10 – 35) Serum albumin (g/L) 37 (35 – 50) Urine: Microscopy Faeces: Microscopy WBC <5 per ml No Cryptosporidium seen RBC <5…Match the letters with the correct leukocyte name