10.18 Using the information in Figs. 10.14 and 10.18, explain how the two oligonucleotides 5'-CAAAGAAAAG-3' and 5'-CTTTTCTTTG-3' assemble into a double helical structure (see Fig. 10.14 for the 3' and 5' numbering, and definitions of C, A, G and T).
10.18 Using the information in Figs. 10.14 and 10.18, explain how the two oligonucleotides 5'-CAAAGAAAAG-3' and 5'-CTTTTCTTTG-3' assemble into a double helical structure (see Fig. 10.14 for the 3' and 5' numbering, and definitions of C, A, G and T).
Biology 2e
2nd Edition
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Chapter15: Genes And Proteins
Section: Chapter Questions
Problem 22CTQ: If mRNA is complementary to the DNA template strand and the DNA template strand is complementary to...
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![10.18 Using the information in Figs. 10.14 and
10.18, explain how the two oligonucleotides
5'-CAAAGAAAAG-3' and 5'-CTTTTCTTTG-3'
assemble into a double helical structure (see Fig.
10.14 for the 3' and 5' numbering, and definitions
of C, A, G and T).
Fig. 10.18. Two strands of oligonucleotides sequenced
5-CAAAGAAAAG-3' and 5'-CTTTTCTTTG-3' assemble into a
double helix. The structure has been determined by X-ray diffraction
[M. L. Kopka et al. (1996) J. Mol. Biol., vol. 334, p. 653]. The
backbone of each oligonucleotide is depicted as an arrow pointing
towards the C3' end of the sequence, and the nucleobases are shown in
a 'ladder' representation. The nucleobases are colour coded: G, green;
A, red; C, purple; T, turquoise.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F00a3542e-c679-4030-a1b6-c1552b026fb7%2F367ba056-bfbe-47d7-b809-88573b31b37a%2Fexj38bb_processed.png&w=3840&q=75)
Transcribed Image Text:10.18 Using the information in Figs. 10.14 and
10.18, explain how the two oligonucleotides
5'-CAAAGAAAAG-3' and 5'-CTTTTCTTTG-3'
assemble into a double helical structure (see Fig.
10.14 for the 3' and 5' numbering, and definitions
of C, A, G and T).
Fig. 10.18. Two strands of oligonucleotides sequenced
5-CAAAGAAAAG-3' and 5'-CTTTTCTTTG-3' assemble into a
double helix. The structure has been determined by X-ray diffraction
[M. L. Kopka et al. (1996) J. Mol. Biol., vol. 334, p. 653]. The
backbone of each oligonucleotide is depicted as an arrow pointing
towards the C3' end of the sequence, and the nucleobases are shown in
a 'ladder' representation. The nucleobases are colour coded: G, green;
A, red; C, purple; T, turquoise.
Transcribed Image Text:to next sugar
to next sugar
H.
p=0
N-H IIO
Me
5'
N H-N
to next
phosphate
to next
phosphate
Adenine-thymine (A-T) base pair
to next sugar
to next sugar
O.
H
O H-N
= nucleobase
N-H IN
(A, T, G or C)
to next
phosphate
N-H O
to next
H
phosphate
Guanine-cytosine (G-C) base pair
Fig. 10.14. The left-hand diagram shows two units in one strand of DNA; DNA is composed of condensed deoxyribonucleotides and the four
possible nucleobases are adenine (A), guanine (G), cytosine (C) and thymine (T).
The right-hand diagrams illustrate how complementary base pairs in adjacent strands in DNA interact through hydrogen bonding. (See also
Fig. 10.18.)
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