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A client comes to the clinic complaining of weight gain and feeling tired. Her blood is drawn and her T4 levels are low and her TSH levels are low. Later, she is given a TSH stimulation test in which TSH is injected and T4 levels are monitored. After TSH injection, her T4 levels rise. Which organ does the client have a problem with?

Question

A client comes to the clinic complaining of weight gain and feeling tired. Her blood is drawn and her T4 levels are low and her TSH levels are low. Later, she is given a TSH stimulation test in which TSH is injected and T4 levels are monitored. After TSH injection, her T4 levels rise. Which organ does the client have a problem with?

check_circleAnswer
Step 1

The thyroid gland produces two hormones- T3 (triiodothyronine) and T4 (thyroxine). These hormones are produced under the influence of thyroid stimulating hormone (TSH), which is released from the anterior pituitary gland. TSH is in turn, stimulated by the thyrotropin-releasing hormone (TRH) produced by the hypothalamus.

Step 2

T4 is produced by the follicular cells of the thyroid gland. Iodine is essential for the production of thyroxine in the thyroid gland. Its deficiency in the body can lead to primary hypothyroidism (low production of thyroid hormone), myxedema (a severe form of hypothyroidism), cretinism, and high level of thyroid-stimulating hormone (TSH). Since T4 is essential for the metabolism in the body, its deficiency causes weight gain and tiredness, which are the signs of central hypothyroidism.

Step 3

In the given case, the patient shows signs of central hypothyroidism as the level of both T4 and TSH are low. However, when a shot of TSH is given to the patient, her T4 level rises. This indicates that the level of T4 is low due to the low production of TSH. Therefore, the problem lies in the well-being of the pituita...

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