A patient X is 60 years old male. Has been diagnosed with CKD (chronic kidney disease). He has been taking Tylenol or Indomethacin for his arthritis during last two years. Why NSAIDs (non-steroid anti-inflammatory drugs) do not affect GFR in patients with normal renal function and why it is not recommended for patients with reduced GFR, especially in patients with CKD?

A patient X is 60 years old male. Has been diagnosed with CKD (chronic kidney disease). He has been taking Tylenol or Indomethacin for his arthritis during last two years. Why NSAIDs (non-steroid anti-inflammatory drugs) do not affect GFR in patients with normal renal function and why it is not recommended for patients with reduced GFR, especially in patients with CKD?

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter14: The Urinary System

Section14.5: Urine Excretion And Plasma Clearance

Problem 1CYU

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CASE SCENARIO ACUTE GLOMERULONEPHRITIS: J.B., female 36 years old, single, a bus conductor was apparently well, until 4 days prior to admission, when she experienced dizziness and headache while at work. Once parked at the terminal, she asked to be checked in the clinic and BP was recorded at 180/100 mmHg, which was unusual since she usually had a BP of 90/60 mmHg. Clonidine 75 mcg was placed sublingual, which reduced her BP to 150/90 mmHg. She was then advised by the company nurse to go home. 2 days PTA, a co employee noticed that her eyes were puffy and even kidded if she broke off with her boyfriend. She just shrugged off the comment and did her usual chores. Few hours PTA, while preparing for work, she noticed blood in the toilet bowl after urinating, which prompted her to seek consult and eventually admission. Her history is essentially negative for past kidney or urinary problems. She admitted that her eyes seemed a little puffy, but she thought this was due to lack of sleep and…