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- scenario NAME OF PATIENT TIME OF EXTRACTION PLASMA CONCENTRATION OF PARACETAMOL (mcg/mL) CD 6:55 PM 120 EF 8:15 PM 55 GH 9:20 PM 42 IJ 11:30 AM 6 KL 12:40 AM 20 MN 4:30 AM 38 OP 6:15 AM 58 QR 7:20 AM 67 ST 8:40 AM 23 UV 9:05 AM 14.5 CD, a 5 year male was discovered by his mother holding a half-filled bottle of Paracetamol 500mg tablets at 6 AM. EF, a 16 year-old female was brought in by her roommate who found her inside the bathroom holding blister pack around 3 PM. GH, a 2 year-old male was given 2 tablets of Paracetamol 250mg by his mother at 8:30 AM. IJ, a 6 year-old male mistakenly took the drug for candy. According to his mother, he took the tablets at around 11 PM yesterday. KL, a 16 year-old female intentionally took 46 tablets of Paracetamol 500mg at 4 PM. MN, a 40 year-old took 20 tablets at around 12 PM. OP, a 6 year-old male received a miscalculated dose of Paracetamol IV at…The doctor ordered PLR 1L (80/ml hour) for a 78 kg patient. The Surviving Sepsis Guideline indicates that "For patients with sepsis induced hypoperfusion or septic shock we suggest that at least 30 mL/kg of intravenous (IV) crystalloid fuid should be given within the frst 3 h of resuscitation." Does the ordered medication comply with the guideline? If not, what should be the infusion rate of the PLR 1L and how many PLR 1L will be used?Explain F factor excision from Hfr integration.
- Need help for MCQ's. Do explain9. A male patient (83-kg IBW) is intubated and ventilated with PC-CMV, f = 12/min, set PIP = 28 cm H2O, resulting in a VT of 430 mL. The ABG results on this setting are: pH 7.35, PaCO2 45 mm Hg, and HCO3− 23 mEq/L. Forty-eight hours later on the same settings, the ABG results are: pH 7.54, PaCO2 27 mm Hg, and HCO3 − 21 mEq/L with an exhaled VT of 800 mL. The most appropriate action at this time is which of the following?a. Decrease PIP to 25 cm H2O.b. Decrease PIP to 19 cm H2O.c. Decrease f to 10/min.d. Decrease f to 8/min.9. A male patient (83-kg IBW) is intubated and ventilated with PC-CMV, f = 12/min, set PIP = 28 cm H2O, resulting in a VT of 430 mL. The ABG results on this setting are: pH 7.35, PaCO2 45 mm Hg, and HCO3 − 23 mEq/L. Forty-eight hours later on the same settings, the ABG results are: pH 7.54, PaCO2 27 mm Hg, and HCO3− 21 mEq/L with an exhaled VT of 800 mL. The most appropriate action at thistime is which of the following?a. Decrease PIP to 25 cm H2O.b. Decrease PIP to 19 cm H2O.c. Decrease f to 10/min.d. Decrease f to 8/min.
- Compute for the required amount of the ingredients necessary to make 20g suppository on 105g (not 100g as shown on the table below.) Ingredients Original Amount Computed Amount Glycerin (1.249 g/mL) 91.0 g Sodium Stearate 9.00 g Water (1 g/mL) 5.0 g To make 100 grams Additionally, the photo shows the computation to make 30 g suppositories in 100 g.Beth R. (58 kg, 63 years old) is suffering from symptomatic ventricular arrhythmia. She will be started on an oral multiple-dose regimen with the antiarrhythmic mexiletine. The population average values of mexiletine for clearance and volume of distribution are Cl = 0.5 L/h/kg and V = 6 L/kg, respectively. Although a therapeutic range of 0.5– 2 mg/L has been described, avoiding large peak-to- trough fluctuations is recommended. The available oral dosage forms are 150, 200, and 250 mg capsules with an oral bioavailability of 0.9%. Design an appropriate and practical oral-dosing regimen that keeps the plasma concentrations at an average concentration of approximately 1 mg/L, with a peak-to-trough fluctuation of less than or equal to 100% (between 0.75 and 1.5 mg/L). What dosing regimen should be used? A. 150 mg every 6 hours B. 200 mg every 6 hours C. 200 mg every 8 hours D. 250 mg every 8 hoursGentamicin 340 mg (7 mg/kg/dose) IV q24h regimen. Kinetics calculated to be: Ke calculated to be 0.254 and half-life is 2.73 hours. Cmax (after end of infusion) calculated to be 19.37 mcg/mL. Time undetectable until next dose is about 12.34 hours. Tonight patient had a dose given at 1801 and this ran for 60 minutes. Gentamicin level resulted 9.25 mcg/mL @ 2230. Infectious disease doctor is okay with just doing 3 hr level since time undetectable is of little significance for her indication. Can calculate Cpk with previous Ke. Renal function has improved so no expected toxicity but still want to verify that patient is clearing. Please calculate Cpk and should I keep the regimen as is or change it?
