AMEL locus

Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter6: Safe Dosage Calculations
Section: Chapter Questions
Problem A.10CRQ
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I need some help completing this fill-in-the-blank. Each answer option is bolded and bracketed.

 

1. The purpose of the AMEL locus is [identification of ethnicity, determination of age, identification of gender], it is located in the [autosomes, sx chromosomes]. Females have only one peak originating from their [X only, Y only, X and Y] chromosomes and males have two peaks originating from their [X only, Y only, X and Y] chromosomes.

2. In the D8S1179 locus, Sophie is [homozygous, heterozygous] for allele with 13 copies. One copy of this allele came from her mother and the other copy came from [Sam or Bill, Sam or Harry, Bill or Harry, Sam Bill or Harry(Either 3)]

3. In the D21S11 locus, Sophie's allele [28, 30] came from the mother and her other allele, 28, came from [Sam only, Bill only, Harry only].

4. In the D18S51 locus, Sophie's paternal allele came from [Bill only, Bill and Harry, Sam Bill or Harry (Either 3)].

5. You already know Sam, Bill and Harry are related to one another. Two of them are brothers and the other is a cousin. Knowing that DYS391 is located on the Y chromosome, can you figure out who are the two brothers and who is the son of their father's sister? Keep in mind that Y chromosome is passed virtually unchanged from father to all of his sons. [Sam and Bill, Sam and Harry, Bill and Harry] are brothers and [Sam, Bill, Harry] is the cousin.

STR Panel 2
Sophie
Donna
Sam
Bill
Harry
AMEL D8S1179 D21S11
Yinde AN
X
Yinde AN
X
Yinde AN
2 X Y
inde AN
2 X Y
YindelAMEL
2 X Y
D8S1179
140
13
D8S1179
140
11
13 14
D8S1179
140
13 14
D8S1179
140
13
D8S1179
140
12 13
D21S11
210
28 30
D21S11
210
27 30
D21S11
210
29 31
D21S11
210
28 30
D21S11
210
30
D18S51
280
280
280
D18S51
13 15
280
15
280
D18S51
13 16
D18S51
D18S51
15
D18S51
15
• DYS391
350
350
350
350
350
DYS391
DYS391
DYS391
10
DYS391
11
DYS391
11
Transcribed Image Text:STR Panel 2 Sophie Donna Sam Bill Harry AMEL D8S1179 D21S11 Yinde AN X Yinde AN X Yinde AN 2 X Y inde AN 2 X Y YindelAMEL 2 X Y D8S1179 140 13 D8S1179 140 11 13 14 D8S1179 140 13 14 D8S1179 140 13 D8S1179 140 12 13 D21S11 210 28 30 D21S11 210 27 30 D21S11 210 29 31 D21S11 210 28 30 D21S11 210 30 D18S51 280 280 280 D18S51 13 15 280 15 280 D18S51 13 16 D18S51 D18S51 15 D18S51 15 • DYS391 350 350 350 350 350 DYS391 DYS391 DYS391 10 DYS391 11 DYS391 11
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