An 85-ycar-old man has a discrepancy between his forward grouping (ABO antigens) and reverse grouping (ABO antibodies). ABO Testing Results Patient RBCS Negative Negative Patient Serum Anti-A typing sera Anti-B typing sera A-1 RBCS B RBCS 2+ Negative A. What is the most likely cause of the discrepancy between ABO antigens and antibodies in this patient? B. How can this discrepancy be resolved?
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- What would happen if patient 4 (O+) donated plasma to patient 1 (A+)? Select one: a. You cannot donate only plasma. b. The anti-A antibodies in the plasma of patient 4 would agglutinate with the antigens on the RBC of patient 1. c. It would be a safe donation because no agglutination would occur. d. The anti-A antibodies in the plasma of patient 1 would agglutinate with the antigens on the RBC of patient 4.You just received the properly labeled blood bank specimen on patient Aran Stark. You decide to collect some background information about her known historical antibodies before beginning the work-up knowing that she has a history of anti-E, anti-K, anti-Jk^a, anti-Fy^a, anti-M and anti-Le^a. Which antibody can be neutralized? Which antibody is destroyed with 0.2M DTT treatment? Which antibody reactivity is enhanced by acidification? Which of the antibodies that are typically IgG in nature are destroyed by enzymes? Which are enhanced by enzymes? Which of these antibodies have been known to cause hemolytic transfusion reaction? Which of these antibodies are known to react at room temperature? Which of these antibodies react best at 37C? * When you complete the work-up, you note that the anti-Jk^a antibody is no longer detectable. Can the patient receive red blood cells that contain the Jk^a antigen? Why or why not?You just received the properly labeled blood bank specimen on patient Aran Stark. You decide to collect some background information about her known historical antibodies before beginning the work-up knowing that she has a history of anti-E, anti-K, anti-Jk^a, anti-Fy^a, anti-M and anti-Le^a. Which of these antibodies have been known to cause hemolytic transfusion reaction?
- A sample from a 70-year-old Caucasian female was submitted for pretransfusion workup for hip surgery in 1 week. Two units of autologous RBCs were reserved for this patient. Because the physician anticipated the need for additional units, routine compatibility testing procedures were performed. The patient had no history of recent transfusions. Results of the ABO and D phenotypes and antibody screen are in the image. 1. Based on the antibody screen results, what antibody class is demonstrating?2. What is the specificity of this antibody: alloantibody or autoantibody?3. What additional testing should be performed to determine the answer to question 2?A 60-year-old woman with anemia is admitted to the hospital. Her hematocrit is 17% and she has been experiencing subtle gastrointestinal bleeding over many weeks. Her physician requests 4 units of red blood cells for transfusion. The patient’s RBCs phenotyped as group AB, D-positive. Her antibody screen is negative on the sample drawn in the emergency room, but her records indicate a previously detected anti-E. Only three group AB, D-positive red blood cell units are available in the blood bank’s inventory. The blood bank’s inventory contains RBC donor units of all ABO and D types.Having located 6 E-negative donor units, you perform crossmatching on the units. One of the units is incompatible in the antiglobulin phase (2+). The physician is becoming insistent on beginning the transfusion, since the patient is having some shortness of breath.How do you respond to the physician’s request?List several reasons to explain the one incompatible donor unit.What additional testing do you…Due to a clerical error, several blood samples at a blood bank were not labeled. The three list below were conducted on each sample to identify each blood type. Test 1 = Unknown sample mixed with “anti-A” serum (contains type A antibodies) Test 2 = Unknown sample mixed with “anti-B” serum (contains type B antibodies) Test 3 = Unknown sample mixed with “anti-Rh” serum (contains type Rh antibodies) (A) When unknown sample A was tested, agglutination (clumping) of red blood cells occurred in test 1, 2 and 3. The blood type of sample A is… (B) When unknown sample B was tested, no agglutination (clumping) of red blood cells occurred in any tests. The blood type of sample B is… (C) When unknown sample C was tested, agglutination (clumping) of red blood cells occurred in test 2 and 3, but not 1. The blood type of sample C is…
- You just received the properly labeled blood bank specimen on patient Aran Stark. You decide to collect some background information about her known historical antibodies before beginning the work-up knowing that she has a history of anti-E, anti-K, anti-Jk^a, anti-Fy^a, anti-M and anti-Le^a. Which antibody reactivity is enhanced by acidification?Which of the following is correct regarding individuals who are blood type AB? A) Their red blood cells only have the H antigen. B) They carry anti-A antibodies. C) They carry anti-B antibodies. D) They are the universal donors. E) They are the universal recipients.A patient's ABO typing was determined to be A NEGATIVE and their antibody identification panel showed that they had antibodies for ANTI-E and ANTI-c. 1. Given that the ABO and Rh has been confirmed independently by a second person, which of the following compatibility tests would be appropriate for making blood available for this patient? Electronic or assigned by the Blood Bank computer System Immediate Spin Cross match Complete IgG Cross match Biological Cross match 2. Given that the ABO and Rh has NOT been confirmed independently by a second person, which of the following compatibility tests would be appropriate for making blood available for this patient? Electronic or assigned by the Blood Bank computer System Immediate Spin Cross match Complete IgG Cross match Biological Cross match
- If detected in antibody screen testing, which of the following antibodies is NOT considered clinically significant in prenatal patients? Please select the single best answer Anti-M Anti-N Anti-Leb Anti-FyaFor each blood type in the table below, fill in the expected agglutination result from mixing the blood with eachof the antibodies.A(n) _________________ is a defensive protein present in the white blood cells that acts to protect the body from injection and can react with ______________ present on RBCs. Options to chose from Antibody Antigen Platelet