Medical Terminology for Health Professions, Spiral bound Version (MindTap Course List)
8th Edition
ISBN:9781305634350
Author:Ann Ehrlich, Carol L. Schroeder, Laura Ehrlich, Katrina A. Schroeder
Publisher:Ann Ehrlich, Carol L. Schroeder, Laura Ehrlich, Katrina A. Schroeder
Chapter5: The Cardiovascular Sytem
Section: Chapter Questions
Problem 91LE
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Question
Several members of the family in the pedigree who suffered from a disease are colored in black. Currently deceased members of the family are struck out with a line.
- Based on the data in the pedigree, propose a Mendelian model that would explain the inheritance of this disease. Explain how the data is consistent with your model.
- A scientist hypothesizes that a mutation at a single locus is responsible for the pattern of inheritance seen in this pedigree. Explain how a mutation in a gene can arise during meiosis. Describe one strategy organisms use to prevent such mutations from arising.
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Expert Solution
Step 1
As per the pedigree shown this disease has x-linked recessive mode of inheritance. This is based on the below mentioned observations.
1- In generation two since only 1 male offspring is affected by the disease thus indicating mother being the carrier. The possibility of autosomal recessive nulled out on the fact of the probability as seen in first generation where one male is affected while the other is not affected which is 50-50 as seen in x-linked inheritance.
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