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CASE STUDY 11.2 Victoria and Rusty were worried about their infant Bailey since his first trip to the hospital at 3 weeks of age. At that time, he had a temperature of 103°F and a runny nose. The emergency department physician examined the infant, but determined the child was suffering from a common cold, probably brought home by his older siblings, and that all would be fine. Since then Bailey's health has not improved and he has experienced an unusual number of bacterial infections. The antibiotics that Bailey's pediatrician prescribed have cleared up the bacterial respiratory infections, but the infection seems to recur. Bailey is now back at the hospital with pneumonia and his physician has ordered a number of laboratory tests as he is now worried about Bailey's immune system. The studies show that Bailey has normal levels of B cells and T cells, with his immunoglobulin levels and hematology results listed in Case Study Table 11.2.1. CASE STUDY TABLE 11.2.1 Laboratory Results Test Result Reference Interval 6 mo-2 y: 30.9-37.0% 6 mo-2 y: 10.3-12.4 g/dL Hematocrit 35% Hemoglobin 11.9 g/dL White blood cell count 14.0 x 10uL 6 mo-2 y: 6.2-14.5 x 10uL IgG 153 mg/dL 1-3 y: 507-1,407 mg/dL IgM 576 mg/dL 1-3 y: 18-171 mg/dL IgA 11 mg/dL 1-3 y: 63-298 mg/dL IgD O mg/dL Newborn to adult: 0-8 mg/dL IgE 1 kIU/L 1-3 y: <90 klU/L Total protein 8.7 g/dL 1 y: 5.4-7.5 g/dL Albumin 3.8 g/dL 1-3 y: 3.4-4.2 g/dL Questions 1. Which immunoglobulin type(s) are abnormal in this patient's serum? 2. How do the laboratory results correlate with recurring bacterial infections? 3. How does isotype switching explain the lack of IgG, IgA, and IgE in this patient's serum?

CASE STUDY 11.2 Victoria and Rusty were worried about their infant Bailey since his first trip to the hospital at 3 weeks of age. At that time, he had a temperature of 103°F and a runny nose. The emergency department physician examined the infant, but determined the child was suffering from a common cold, probably brought home by his older siblings, and that all would be fine. Since then Bailey's health has not improved and he has experienced an unusual number of bacterial infections. The antibiotics that Bailey's pediatrician prescribed have cleared up the bacterial respiratory infections, but the infection seems to recur. Bailey is now back at the hospital with pneumonia and his physician has ordered a number of laboratory tests as he is now worried about Bailey's immune system. The studies show that Bailey has normal levels of B cells and T cells, with his immunoglobulin levels and hematology results listed in Case Study Table 11.2.1. CASE STUDY TABLE 11.2.1 Laboratory Results Test Result Reference Interval 6 mo-2 y: 30.9-37.0% 6 mo-2 y: 10.3-12.4 g/dL Hematocrit 35% Hemoglobin 11.9 g/dL White blood cell count 14.0 x 10uL 6 mo-2 y: 6.2-14.5 x 10uL IgG 153 mg/dL 1-3 y: 507-1,407 mg/dL IgM 576 mg/dL 1-3 y: 18-171 mg/dL IgA 11 mg/dL 1-3 y: 63-298 mg/dL IgD O mg/dL Newborn to adult: 0-8 mg/dL IgE 1 kIU/L 1-3 y: <90 klU/L Total protein 8.7 g/dL 1 y: 5.4-7.5 g/dL Albumin 3.8 g/dL 1-3 y: 3.4-4.2 g/dL Questions 1. Which immunoglobulin type(s) are abnormal in this patient's serum? 2. How do the laboratory results correlate with recurring bacterial infections? 3. How does isotype switching explain the lack of IgG, IgA, and IgE in this patient's serum?

Surgical Tech For Surgical Tech Pos Care
Surgical Tech For Surgical Tech Pos Care
5th Edition
ISBN:9781337648868
Author:Association
Publisher:Association
Chapter17: Otorhinolaryngologic Surgery
Section: Chapter Questions
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CASE STUDY 11.2 Victoria and Rusty were worried about their infant Bailey since his first trip to the hospital at 3 weeks of age. At that time, he had a temperature of 103°F and a runny nose. The emergency department physician examined the infant, but determined the child was suffering from a common cold, probably brought home by his older siblings, and that all would be fine. Since then Bailey's health has not improved and he has experienced an unusual number of bacterial infections. The antibiotics that Bailey's pediatrician prescribed have cleared up the bacterial respiratory infections, but the infection seems to recur. Bailey is now back at the hospital with pneumonia and his physician has ordered a number of laboratory tests as he is now worried about Bailey's immune system. The studies show that Bailey has normal levels of B cells and T cells, with his immunoglobulin levels and hematology results listed in Case Study Table 11.2.1. CASE STUDY TABLE 11.2.1 Laboratory Results Test Result Reference Interval 6 mo-2 y: 30.9-37.0%% 6 mo-2 y: 10.3-12.4 g/dL Hematocrit 35% Hemoglobin 11.9 g/dL 14.0 x 10uL 6 mo-2 y: 6.2-14.5 x 10/uL White blood cell count IgG 153 mg/dL 1-3 y: 507-1,407 mg/dL IgM 576 mg/dL 1-3 y: 18-171 mg/dL IgA 11 mg/dL 1-3 y: 63-298 mg/dL IgD O mg/dL Newborn to adult: 0-8 mg/dL IgE 1 kIU/L 1-3 y: <90 kIU/L Total protein 8.7 g/dL 1 y: 5.4-7.5 g/dL Albumin 3.8 g/dL 1-3 y: 3.4-4.2 g/dL Questions 1. Which immunoglobulin type(s) are abnormal in this patient's serum? How do the laboratory results correlate with recurring bacterial infections? 2. 3. How does isotype switching explain the lack of IgG, IgA, and IgE in this patient's serum?
Transcribed Image Text:CASE STUDY 11.2 Victoria and Rusty were worried about their infant Bailey since his first trip to the hospital at 3 weeks of age. At that time, he had a temperature of 103°F and a runny nose. The emergency department physician examined the infant, but determined the child was suffering from a common cold, probably brought home by his older siblings, and that all would be fine. Since then Bailey's health has not improved and he has experienced an unusual number of bacterial infections. The antibiotics that Bailey's pediatrician prescribed have cleared up the bacterial respiratory infections, but the infection seems to recur. Bailey is now back at the hospital with pneumonia and his physician has ordered a number of laboratory tests as he is now worried about Bailey's immune system. The studies show that Bailey has normal levels of B cells and T cells, with his immunoglobulin levels and hematology results listed in Case Study Table 11.2.1. CASE STUDY TABLE 11.2.1 Laboratory Results Test Result Reference Interval 6 mo-2 y: 30.9-37.0%% 6 mo-2 y: 10.3-12.4 g/dL Hematocrit 35% Hemoglobin 11.9 g/dL 14.0 x 10uL 6 mo-2 y: 6.2-14.5 x 10/uL White blood cell count IgG 153 mg/dL 1-3 y: 507-1,407 mg/dL IgM 576 mg/dL 1-3 y: 18-171 mg/dL IgA 11 mg/dL 1-3 y: 63-298 mg/dL IgD O mg/dL Newborn to adult: 0-8 mg/dL IgE 1 kIU/L 1-3 y: <90 kIU/L Total protein 8.7 g/dL 1 y: 5.4-7.5 g/dL Albumin 3.8 g/dL 1-3 y: 3.4-4.2 g/dL Questions 1. Which immunoglobulin type(s) are abnormal in this patient's serum? How do the laboratory results correlate with recurring bacterial infections? 2. 3. How does isotype switching explain the lack of IgG, IgA, and IgE in this patient's serum?
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